Unknown's avatar lassesen 7:08 am on January 11, 2020  

Drug induced histamine issues

I came across an interest article on enteral-induced histaminosis (Histaminosis: Studies on Three Prognostic Variables in an Epidemiological Model) which identifies some drugs that inhibit DAO production.

This lead me to this page which gives a fuller list with citations.

Active substanceExamples of products ®CategoriesHistamine effectsReferences
Acemetacin AntirheumaticDAO inhibitor[Sattler 1985, Fritzsche 2009]
Acetyl­cysteineFluimucil, Helvetussin, Muco-Mepha, NeoCitran, SolmucolMucolytic, antidoteDAO inhibitor[Jarisch 2004, Maintz et al. 2006]
Acriflavin AntisepticDAO inhibitor[Fritzsche 2009]
Alcuronium Muscle relaxantDAO inhibitor[Sattler 1985, Maintz et al. 2006, Forth 2008]
Alprenolol Beta blockerDAO inhibitor[Maintz et al. 2006]
AmbroxolAmbrovene, Ambroxol, Broxol, Mucosolvan, MucospasExpectorantDAO inhibitor[Jarisch 2004, Maintz et al. 2006]
Aminocycline  DAO inhibitor[Sattler 1985]
AminophyllinEuphyllin, Mundiphyllin, MyocardonAntiasthmaticDAO inhibitor[Sattler 1985, Jarisch 2004, Maintz et al. 2006]
Amiphenazole  DAO inhibitor[Sattler 1985]
AmitriptylineSaroten, Tryptizol, LimbritolTricyclic antidepressantDAO inhibitor[Jarisch 2004, Maintz et al. 2006]
Carbocromene  DAO inhibitor[Sattler 1985]
Cefotiam AntibioticDAO inhibitor[Maintz et al. 2006]
Cimetidine H2 antihistamineDAO inhibitor[Prof. Ralf Bauer Uni Bonn; found in: Jarisch 2004 S.12, Maintz et al. 2006, Fritzsche 2009]
Clavulanic acidAugmentinAntibioticDAO inhibitor[Sattler 1985, Jarisch 2004, Maintz et al. 2006]
Colistin mesilate  DAO inhibitor[Sattler 1985]
DiazepamValiumTranquilizerDAO inhibitor[Fritzsche 2009]
DihydralazineNepresolAntihypertensive, vasodilatorDAO inhibitor[Wantke et al. 1989, Sattler 1985, Maintz et al. 2006, Fritzsche 2009]
Fenpiverinium  DAO inhibitor[Sattler 1985]
Framycetin AntibioticDAO inhibitor[Sattler 1985, Fritzsche 2009]
FurosemideLasixDiureticDAO inhibitor[Fritzsche 2009]
HaloperidolHaldolNeurolepticDAO inhibitor[Fritzsche 2009]
Metamizole, dipyronesNovalgin, MinalginAnalgesic, antipyreticDAO inhibitor[Jarisch 2004, Maintz et al. 2006]
MetoclopramideMigpriv, Paspertin, PrimperanAntiemetic, gastroenterologic, dopamine antagonistDAO inhibitor[Sattler 1985, Jarisch 2004, Maintz et al. 2006]
Neomycin AntibioticDAO inhibitor[Mathelier-Fusade 2006]
Novamine sulfone(=Metamizol) Novalgin, MinalginAnalgesic, antipyreticDAO inhibitor[Jarisch 2004]
Orciprenaline  DAO inhibitor[Sattler 1985]
Pancuronium Muscle relaxantDAO inhibitor[Sattler 1985, Maintz et al. 2006, Fritzsche 2009]
Pentamidine AntibioticDAO inhibitor[Sattler 1985, Maintz et al. 2006]
Pirenzepine  DAO inhibitor[Sattler 1985]
Prilocaine Local anaestheticDAO inhibitor[Maintz et al. 2006, Nesterenko 2010]
PromethazineAtosil, Closin, Proneurin, ProthazinSedative, antihistamine, antipsychoticDAO inhibitor[Irion 2009]
PropafenoneRytmonormAntiarrhythmicDAO inhibitor[Jarisch 2004, Maintz et al. 2006]
Propanidide AnaestheticDAO inhibitor[Nesterenko 2010]
Quinidine CardiacDAO inhibitor[Fritzsche 2009]
Tetroxoprim  DAO inhibitor[Sattler 1985]
VerapamilFlamon, Isoptin, TarkaCoronaryvasodilatant, antihypertensive, antiarrhythmic, calcium antagonistDAO inhibitor[Jarisch 2004, Maintz et al. 2006]
D-CycloserineSeromycinAntibioticDAO inhibitor (Vitamin B6-Antagonist)[Sattler 1985, Steneberg 2007]
IsoniazideRimifon, RifaterTuberculostaticDAO inhibitor (Vitamin B6-Antagonist)[Jarisch 2004, Maintz et al. 2006]
ChloroquineChlorochin, Nivaquine, ResochinAntimalarials, antirheumaticDAO inhibitor, HNMT-Blocker[Sattler 1985, Jarisch 2004, Donatelli et al. 1994, Maintz et al. 2006]

Bottom Line

The list are items that you should NOT take because they reduce DAO and can result in fatal histamine reactions if you already have histamine issues. Decision to stop any should be done in consultation with your medical professional.