Hafnia alvei 4597 Probiotic is available


A reader forwarded this to me with the following comment..

My mother is a health 58 years old women a little bit over weight she started to have after 2 weeks of use: headaches and feeling very fatigued so I think she has die-off, The interesting thing that happen she has swollen lymph nodes under her arm pits for about 25 plus years, the lumps started to regress, I cannot find the microbiome condition associated with this and this strain of probiotic she started to use.

Entero Satys

This is available from France. Link here. International availability is unknown. “Hafnia alvei is a psychrotrophic bacterium, it originates in raw milk and continues to grow in cheeses such as Camembert.  abundant levels of Hafnia alvei can be found in raw milk cheese ” [Wikipedia]

This image has an empty alt attribute; its file name is enterosatys.jpg

Ingredients:
 Corn starch; coating agent: hydroxypropylmethylcellulose; freeze-dried bacterial strain ( Hafnia alvei 4597 ); gelling agent: gellan gum; zinc (zinc bisglycinate, glycine, acidifier: citric acid, anti-caking agent: silicon dioxide [nano]); anti-caking agents: magnesium salts of fatty acids; chromium (picolinate).

Research

Hafnia alvei HA4597 Strain Reduces Food Intake and Body Weight Gain and Improves Body Composition, Glucose, and Lipid Metabolism in a Mouse Model of Hyperphagic Obesity 2019

  • “In conclusion, the present study showed that a daily provision of the H. alvei HA4597™ strain in genetically obese and hyperphagic ob/ob mice with HFD-exacerbated obesity decreased body weight gain, improved body composition, decreased food intake, and ameliorated several metabolic parameters, including plasma glucose and total cholesterol levels. “

Commensal Hafnia Alvei Strain Reduces Food Intake and Fat Mass in Obese Mice-A New Potential Probiotic for Appetite and Body Weight Management 2020

  • “Finally, the low abundance of ClpB gene expressing Enterobacterales species found in the microbiota of obese subjects in the present in silico analysis may indicate insufficient anorexigenic signaling from the gut microbiota to the host, further providing the rationale for supplementation of commensal bacteria expressing the ClpB protein with an α-MSH-like motif. “

Role of the Gut Microbiota in Host Appetite Control: Bacterial Growth to Animal Feeding Behaviour, 2017

Bottom Line

There was no detail microbiome information cited in studies above. The mechanism of operation was increase production of a metabolite from this bacteria that alters the number of meals and result in weight loss.

The daily dosage is 50 million CFU ** / 100 billion cells, i.e. 5 x 10^7. Some (made in France) Camembert are reported to exceed this level in 1 gram (especially the surface).

It is available as a specialized cheese starter.


Hay Fever and Probiotics

The wife is having a rough time this year with hay fever. I asked her to try one of the suggestions below and she noticed improvement within a hour.

So for all of you that are overdosing on antihistamines, this post may help.

The last item does not have any studies that I could find, I did find that with seasonal allergies that “The pollen season induced a reduction in Bifidobacterium, Clostridium and Bacteroides which could not be prevented by the [Lactobacillus, Bifidobacterium] probiotic intervention. “[2009]. The study did not try Miyarisan (Clostridium butyricum), which the wife found helped quickly.

Bottom Line

Encouraging or supplementing Bifidobacterium and Clostridium as probiotics should reduce severity. Most of the studies used Bifidobacterium.

Hemex’s ISAC Panel for ME/CFS is available

Hemex was subsequently purchased and David Berg’s ISAC panel was subsequently dropped. His studies found that over 70% of CFS/ME patients have hypercoagulation which was often a major factor for symptoms and for successful treatment.

A reader surprised me this week because a German lab had worked with David Berg and implemented the ISAC panel — and continue to offer it.

Dedimed Lyme Disease Laboratory
https://dedimed.com/en/doctors/therapy-center/

Antibiotic therapy and no recognizable improvement in symptoms?

In more than 60% of all bacterial infectious diseases, the pathogens form biofilms, which protect them from attack by the immune system. The hematologist D. Berg has developed the “ISAC” protocol to recognize a biofilm. (ISAC: Immune System Activation of Coagulation). When a biofilm is detected, he recommends the use of lumbrokinase for removal. The new formation of a biofilm during the therapy is prevented eg. by low molecular weight heparin. The Dedimed Europarc Laboratory carries out the biofilm testing, which we recommend before any lengthy antibiosis.

For more information see this talk with David Berg (#4) and a radio program with him.

The reader reported:

I talked to Dr. Waldherr for 45 minutes he is unbelievable good informed about almost everything and he said to me, that he and his colleagues reached up to Dr. Berg to finde out how to perform the tests. 
The actual test is done in Berlin from Dr. Sucker and the treatment is then given low molecule Heparin etc. he also knows all the enzymes used like Nattokinase, Lumbrokinase etc. he also speaks English which is also a good thing if people don’t speak german. 

The cost is much less than what I paid in 1999!

Post Viral Syndrome – Case Study

On Feb 15th I was running a high temperature, definitely coming down with something and the next day I had a seizure (my first one ever). I was sent to hospital and stayed there for several days. This post record some interesting observations both as a ME/CFS person and a person with an unknown virus (not COVID-19) that echo some aspects reported for COVID-19.

Onset

I happened to be wearing a watch (Cheap $18 watch from China) that records my pulse and blood pressure every hour. This is what was recorded. Impressive changes

Tests

The symptoms presented like sepsis, so I was placed on multiple high dosage antibiotics. Testing found nothing (Flu, bacteria, and even a spinal tap to check for meningitis). Many CRT and MRI scans. Nothing was found so the most likely cause was a viral infection of unknown type.

The fever lasted for about 3 days. I was given beta blockers, heparin etc.

Blood Sugar

It was measured by the ambulance crew and was at the high end of the normal range. For the next three days it was quite high outside of the normal range. On day 4 it returned to the middle of the normal range.

This is significant for COVID-19, because people with high blood sugar (diabetes) have a higher fatality rate. I suspect that the same increase of blood pressure pushes things still higher to the lethal range in some.

My Glucose levels — it was below 100 when the ambulance picked me up

C-Reactive Protein

If your examine my post on another blog on symptoms, you will see that high values of c reactive protein are associated with higher death rates for Covid-19 [PubMed]

C Reative Protein levels

Blood Pressure and Pulse

These stayed high and were still abnormally high at discharge. I started on supplements proven in studies to lower blood pressure, and they helped quickly but BP stayed erratic (jumping from normal to high for 2 hrs and then back), just less so over time.

A reader referred me to this study of MERS-CoV, another Coronavirus. The item that helped was resveratrol, which also lowers blood pressure (may be the mechanism it works thru).

Discharge

The moment that I got home, I did a microbiome test (Thryve) with a primary focus on correcting changes from the antibiotics. For the abnormal high blood pressure, I hit it with literally everything that was documented (see here for the list). Blood pressure and pulse initially went back to normal and then started jumping around with no apparent explanation at the time.

Oops on Supplements

I received my Thryve microbiome results and was not surprise to see the chart shown below. It indicated that the jump of blood pressure was a result of microbiome changes induced by the virus.

BP jumped due to virus induced changes of the microbiome

I then identified which shifts were key:

The interesting thing was that comparing the recommendations for this mixture and the studies, we had good overlap — but a few appear on the avoid list. I removed those from my supplements, and things improved more.

It illustrates that results from the general population may not apply to an individual. I had a subset of the high BP bacteria and being specific to those bacteria is preferred.

Hypercoagulation vs Pulse and Blood Pressure

One of the things that I noticed was that my 02 saturation was not the normal 99%. A rock steady 99%.

  • When my pulse and BP went to normal for a few hours, O2 dropped to 94%
  • When my pulse and BP went high, my O2 returned to 99%

Conversations with Dave Berg, Hemex Labs, came back. Infections often trigger coagulation (blood thickening). The light went on! The increase of both pulse and blood pressure may be a response to the low O2 level and an attempt to restore O2 levels.

As a side note, the hypercoagulation is suspected by some to play a role in postural orthostatic tachycardia syndrome (POTS). The thick blood results in delay of blood pressure in the body resulting in mis-signalling. The rapid increase in heartbeat seen with POTS is an attempt to compensate.

Heart rate and blood pressure work together to keep the blood flowing at a healthy pace, no matter what position the body is in. People with POTS cannot coordinate the balancing act of blood vessel squeeze and heart rate response. This means the blood pressure cannot be kept steady and stable….. Patients may develop POTS after a viral illness, 

Postural orthostatic tachycardia syndrome

I know from ME/CFS days that I have an inherited coagulation defect [Prothrombin G20210A or factor II mutation]. I am one of the lucky ones because there are known substances that will compensate for my particular defect: Piracetam, with tumeric being a secondary choice. I proceeded with 1200 mg of Piracetam with each meal. O2 levels went up, pulse and BP went down more. See below

BP and Pulse stayed in sync

I have a follow up in 2 weeks with my MD and hope to get some heparin to take sublingually (under tongue, not by needle) to further clear the hypercoagulation.

Virus and Coagulation

Bottom Line

It was interesting to see that this unknown virus caused changes in blood sugar and blood pressure. For COVID-19, there are higher death rates (about 9-10%) for people with diabetes (high glucose) and hypertension (high blood pressure) – I suspect that COVID-19 pushes these to potentially fatal levels.

Takeaways: reducing BP and blood sugar proactively and aggressively may be a good strategy. High BP may be connected with hypercoagulation (which may be sub-clinical, i.e. not severe enough for physicians to take action).

ME/CFS Corvid-19 Death Rate: 4.5%

In short, ME/CFS patients are older. Corvid-19 kills older people more often (over 20% in some age ranges). This computes the risk over all ages with ME/CFS. ME/CFS is not causing this high rate, patient ages are.

For reference, Flu Death Rate from CDC for 2018-2019: (=34,157/35,520,883) or 0.0962%. So the risk of death is 46.8x more

This is based on the following studies:

The methodology was to obtain the incidence rates for CFS/ME for items like:

Then obtain the ages and numbers in each age bracket with ME/CFS and then apply the following:

Note that even for the youngest are group, the chance of death is 2x the 2018-19 risk for flu.

As of this morning, there is a very strong statistical model saying that it will go pandemic with every country severely infected. By April 1st, there may be more cases outside of China than in China.