We need more data…

But a symptom of hair loss has some strong trends (3/3) had
* Low Amino acid metabolism: D-Arginine and D-ornithine metabolism .233
* Low Bacterial Abilities: Bacterial chemotaxis .658
* Low Bacterial Abilities: Bacterial motility proteins .658
* Low Bacterial Abilities: Flagellar assembly .575
* Low Secondary metabolite degradation: Dioxin degradation .74
* Low Secondary metabolite degradation: Xylene degradation . 825

See http://microbiomeprescription.com/Metabolite/Explorer?filter=,116

Data Downloads are now available

All of the user entered data is available for citizen scientists (as well as some AI scientists and statisticians with significant others having CFS). This was a promise that I made in collecting the data — make the data freely available without any human identifying information.

Data is now available formatted for intake to R or other statistical software at:

https://citizenscience.microbiomeprescription.com/

As is seen below, this data has been available for 5+ years and the volume of data has growth much

Downloads

Bottom Line

The data is there for any professional or amateur research to use. The greatest value comes when people provide their symptoms and copies the function/metabolites numbers into this shared repository.

CFS/FM/IBS Metabolism deep dives — Fundamentals

On the ubiome function/metabolism report there are several different terms being used which I wish to try to give definition/explanation for the brain-fogged. See this post on how you can contribute to this data

The most important and common are the three shown below.

Metabolism

This means the conversion of a named item into different parts and the parts being reassemble back to the named item.  This of oxygen and carbon dioxide: plants converts carbon dioxide to oxygen, humans convert oxygen to carbon dioxide.

  • If the value is 0.8 – 1.2 , you are naturally producing a normal flow of this item
  • If the value is below 0.8. the flow is reduced. Some if the different parts may be too high or too low (think of baking a cake — too much flour and not enough eggs — if one is out  of step then things are not right).
  • If the value is over 1.2, you may have greater than normal flow. Some if the different parts may be too high or too low (think of baking a cake — too much flour and not enough eggs — if one is out  of step then things are not right).

Needless to say — this gets complex because we are not told the details.

More literature:

Degradation

AKA biodegradation. This means the ability to breakdown specific items into component parts. We can think of this as the ability to clear items from your body.

Low values suggests excessive accumulation. High values may result in being short of this item because it is aggressively removed.

More literature

Biosynthesis

This means that the named item is being produced from the various bacteria from simple chemicals you have.

  • If the value is 0.8 – 1.2 , you are naturally producing a normal amount of this item
  • If the value is below 0.8. supplementation (if available) would be suggested
  • If the value is over 1.2, you may be over-producing this items and may wish to:
    • Eliminate it from supplements or foods rich in it
    • Reduce the bacteria that is producing it (if known)
    • Encourage consumers.

Both High and Low would be expected to cause symptoms.

More literature:

Deep Dives in Metabolism

The following will be the target of subsequent posts (which will be linked to as they are written)

Amino acid metabolism

  1. AverageAlanine, aspartate and glutamate metabolism
  2. Arginine and proline metabolism
  3. beta-Alanine metabolism
  4. Cyanoamino acid metabolism
  5. Cysteine and methionine metabolism
  6. D-Alanine metabolism
  7. D-Arginine and D-ornithine metabolism
    1. Low
    2. Take Ornithine, Arginine (with Lysine), Zinc, glutamine
  8. D-Glutamine and D-glutamate metabolism
  9. Glutathione metabolism
  10. Glycine, serine and threonine metabolism
  11. Histidine metabolism
  12. Lysine biosynthesis
  13. Lysine degradation
  14. Phenylalanine metabolism
  15. Phenylalanine, tyrosine and tryptophan biosynthesis
  16. Phosphonate and phosphinate metabolism
  17. Selenocompound metabolism
  18. Taurine and hypotaurine metabolism
  19. Tryptophan metabolism
  20. Tyrosine metabolism
  21. Valine, leucine and isoleucine biosynthesis
  22. Valine, leucine and isoleucine degradation

Bacterial Abilities

  1. AverageBacterial chemotaxis
  2. Bacterial motility proteins
  3. Bacterial secretion system
  4. beta-Lactam resistance
  5. Cell division
  6. Cell motility and secretion
  7. Flagellar assembly
  8. Lysosome
  9. Phagosome
  10. Sporulation

Carbohydrate metabolism

  1. AverageAmino sugar and nucleotide sugar metabolism
  2. Ascorbate and aldarate metabolism
  3. Butanoate metabolism
  4. C5-Branched dibasic acid metabolism
  5. Citrate cycle (TCA cycle)
  6. Fructose and mannose metabolism
  7. Galactose metabolism
  8. Glycolysis / Gluconeogenesis
  9. Glyoxylate and dicarboxylate metabolism
  10. Inositol phosphate metabolism
  11. Pentose and glucuronate interconversions
  12. Pentose phosphate pathway
  13. Propanoate metabolism
  14. Pyruvate metabolism
  15. Starch and sucrose metabolism

Lipid metabolism

  1. Averagealpha-Linolenic acid metabolism
  2. Arachidonic acid metabolism
  3. Biosynthesis of unsaturated fatty acids
  4. Ether lipid metabolism
  5. Fatty acid biosynthesis
  6. Glycerolipid metabolism
  7. Glycerophospholipid metabolism
  8. Linoleic acid metabolism
  9. Sphingolipid metabolism
  10. Steroid biosynthesis
  11. Steroid hormone biosynthesis
  12. Synthesis and degradation of ketone bodies

Secondary metabolite biosynthesis

  1. Average Betalain biosynthesis
  2. Butirosin and neomycin biosynthesis
  3. Caffeine metabolism
  4. Flavone and flavonol biosynthesis
  5. Flavonoid biosynthesis
  6. Indole alkaloid biosynthesis
  7. Isoquinoline alkaloid biosynthesis
  8. Novobiocin biosynthesis
  9. Penicillin and cephalosporin biosynthesis
  10. Phenylpropanoid biosynthesis
  11. Stilbenoid, diarylheptanoid and gingerol biosynthesis 
    1. HIGH
    2. Take Ginger, Turmeric, Resveratrol, Almonds
  12. Streptomycin biosynthesis
  13. Tropane, piperidine and pyridine alkaloid biosynthesis

Secondary metabolite degradation

  1. AverageAminobenzoate degradation
  2. Atrazine degradation
  3. Benzoate degradation
  4. Bisphenol degradation
  5. Caprolactam degradation
  6. Chloroalkane and chloroalkene degradation
  7. Chlorocyclohexane and chlorobenzene degradation
  8. Dioxin degradation
    1. LOW and deteriorate over time.
    2. Take Activated Charcoal, Resveratrol
  9. Drug metabolism – cytochrome P450
  10. Drug metabolism – other enzymes
  11. Ethylbenzene degradation
  12. Fluorobenzoate degradation
  13. Metabolism of xenobiotics by cytochrome P450
  14. Naphthalene degradation
  15. Nitrotoluene degradation
  16. Polycyclic aromatic hydrocarbon degradation
  17. Styrene degradation
  18. Toluene degradation
  19. Xylene degradation

Vitamin metabolism

  1. AverageBiotin metabolism
  2. Folate biosynthesis
  3. Lipoic acid metabolism
  4. Nicotinate and nicotinamide metabolism
  5. One carbon pool by folate
  6. Pantothenate and CoA biosynthesis
  7. Porphyrin and chlorophyll metabolism
  8. Retinol metabolism
  9. Riboflavin metabolism
  10. Thiamine metabolism
  11. Ubiquinone and other terpenoid-quinone biosynthesis
  12. Vitamin B6 metabolism

 

Five people have added their…

Five people have added their metabolite profile from uBiome to their data.
http://microbiomeprescription.com/Metabolite/explorer

One item sticks out greatly — very low D-Arginine and D-ornithine metabolism for all five.
If you happen to have any readings on treating D-Arginine and D-ornithine metabolism , please forward to me.
My initial take is that means that D-arginine and D-ornithine does not get processed much resulting in a build up. This suggests a low arginine and low ornithine diet could be considered.
“Some of the best choices are soybeans, pumpkin seeds, sesame seeds, peanuts and walnuts. You’ll also get it from sweet green peppers and the seaweed spirulina. Grains such as quinoa, oats and wheat germ deliver arginine, as do a variety of ready-to-eat cereals made from oats, rice and wheat.” https://www.livestrong.com/article/275892-foods-high-in-l-arginine/

I need to do more digging, but hope some of you have already done it and are willing to share!

Kegg Pathway – Metabolism and Microbiome

I have just created a new set of pages to allow people who have done uBiome to share the metabolism information that is also provided there.  I put my own and a friend’s thru and was struck by the differences. Almost all of mine was sitting at .95 – 1.05 of normal. Many of her’s were sitting at 0.03, 0.05 of normal.

Short Explanation

Bacteria have a large number of interactions and behaviors. There is a site where this information has been gathered, KEGG PATHWAY Database. uBiome has used this site with your bacteria sample to predict/estimate how well various pathways are working with your current bacteria mixture.

You will find this information under [Advance] on your uBiome page

meta

There is no ability to download and upload it at present. The items are arrange from highest to lowest value.

I have created an entry page (AFTER YOU LOGIN and pick the sample) at: http://ubiomecfsweb.azurewebsites.net/Metabolite/metabolismEntry

The page is shown below. I have chunked ranges together to make entry easier.

meta2

In general, we are concerned about low values. What the values means and what you can do about them will be covered in later posts when we get data.

Examples:

  • A low “Ubiquinone and other terpenoid-quinone biosynthesis” means that your bacteria under produces Ubiquinone (a.k.a. CoQ10) and thus you should be supplementing with it — perhaps in higher dosages than usual.
  • A low “Styrene degradation” means that you may need to really avoid items with even trace amount styrene, in fact, “The U.S. Environmental Protection Agency (EPA) has described styrene to be “a suspected toxin to the gastrointestinal tract, kidney, and respiratory system, among others”.[29][30] ” which may be a contributing factor for IBS
  • A low “Retinol metabolism” (Vitamin A),  means it takes longer for the body to use it. In some cases if it is water borne, then you may urinate it out unprocessed and have little effect from a normal dosage.

I will likely do deep dives into these — every 5 sets submitted will result in the lowest common values seen being the next deep dive.

A video

For more videos, go to this page.

Bottom Line

Adding metabolites WITH symptoms may help discover association between chemical sensitivity and the metabolic functioning, etc.  We need uBiomes, symptoms and metabolites to obtain a rich set of data to identify symptoms to both bacteria and to metabolites (i.e. hints to the specific supplements that may help you!)

I have also stubbed out a symptoms to metabolite explorer page.

GENDER AND AGE Has Been Added to Symptoms

If you have entered symptoms, please update it with your gender and age.