I suspect there are many other items that have come out of corporate labs that were not evaluated on their impact on the Microbiome before they were approved for use in food. This is just one example. This 2008 study is illuminating on the possible impact on humans.
“At the end of the 12-wk treatment period, the numbers of total anaerobes, bifidobacteria, lactobacilli, Bacteroides, clostridia, and total aerobic bacteria were significantly decreased; however, there was no significant treatment effect on enterobacteria.”
A 2012 study, The antimicrobial activity of the three commercially available intense sweeteners against common periodontal pathogens: an in vitro study. states “All the three sweeteners showed significant antimicrobial activity against the periodontal pathogens tested. Sucralose showed maximum zone of inhibition, against Aggregatibacter actinomycetemcomitans. Saccharin and aspartame showed maximum zone of inhibition, against Porphyromonas gingivalis.”
A 2007 study Effect of chewing gums containing xylitol or probiotic bacteria on salivary mutans streptococci and lactobacilli also found impact.
In fact, going back to 1990, we have The influence of sucralose on bacterial metabolism found “The incorporation of 126 mmol/L sucraloseinto glucose agar medium caused total inhibition of growth of Streptococcus sobrinus 6715-17, Streptococcus sanguis 10904, Streptococcus sanguis Challis, Streptococcus salivarius, and Actinomyces viscosus WVU627. ”
There is a nasty two edge sword here — xylitol is often advocate for a mouth wash or for people with diabetes. It is also lethal for dogs. What we know, dates back to 1985 with Gut microflora interactions with xylitol in the mouse, rat and man. “xylitol feeding caused a clear shift in the rodent faecal microbial population from Gram-negative to Gram-positive bacteria. In human volunteers a similar shift was observed even after a single 30-g oral dose of xylitol. ”
We can even look at this 2012 study looking at Stevia: Antimicrobial potential of extracts from Stevia rebaudiana leaves against bacteria of importance in dental caries. “For the four Lactobacillus… suggesting they were the most susceptible microorganisms.” So yogurt with Stevia is not a wise food choice….
In short, all of the artificial (or greatly concentrated unusual sugars) alter the microbiome. Is it an alteration for the better or the worst? There are no studies, especially for CFS patients — apart from d-ribose (which helps CFS patients).
Trying some of these for 10 days may have a positive effect. If so, then pulse them every 6-12 weeks. If you are regularly using any of them. Get off them for at least 8 weeks and see if there is a change.
We do not know if they help or hinder. They do change. They are effectively non-prescription antibiotics!