Is CFS in your DNA?

This is not a theoretical post, but a practical post!  The site 23AndMe.com offers DNA testing for $99 that gives you almost a million pieces (SNPs) of your DNA. SNP stands for single nucleotide polymorphisms.

There has been several recent papers that has found distinctive DNA for CFS patients and other autoimmune diseases. For this post, I will take one of these papers and show how you can determine if you have “CFS-DNA”.

The paper that I will use is Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome. byGoertzel BN, Pennachin C, de Souza Coelho L, Gurbaxani B, Maloney EM, Jones JF. Pharmacogenomics. 2006 Apr;7(3):475-83.  I actually found a copy of the full text here, courtesy of The WISCONSIN MYALGIC ENCEPHALOMYELITIS / CHRONIC FATIGUE SYNDROME ASSOCIATION, INC.

In table 3, you will see:

SNPs associated with CFS

SNPs associated with CFS

This is typical of what the papers look like, a rs##### on the left and two letter combinations across the top.

Your 23AndMe Matching DNA

With 23AndMe.com(once your results are returned), you will see under your name, a RAW DATA option.

Where you can find your individual SNPs

Where you can find your individual SNPs

So clicking this takes you to a page where you can search, for example, I entered the first SNP (rs####) as shown below:

Results for looking at first SNP

Results for looking at first SNP

My value is “AA”. According to the article, 48% of CFS patients have an “AA” and only 32% of normal people. I can now go on to the other ones and see how many of them are matches for the research (I choose not to disclose the results).

At present there are approximately 20 studies that have been done and more in progress. This is informational only, although it may have some advantage is dealing with MDs and other disbelievers. “If it is all in my head, then why is it also in my DNA?”

Some additional articles available with full text:

  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089886/
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701888/

which has a nice table in it.

Screen Shot 2013-10-28 at 8.35.15 PM

If you have GG for this one, the odds are significantly higher. You will not find all of the SNPs in the 23AndMe dna — but you will find most are listed.

The severity of CFS appears to be echo in your DNA. This does not mean that you are preDNAed to have CFS, it suggests you are more inclined.