Gut Bacteria causing Irritable Bowel Syndrome / CFS

While researching my last post I came across an article describing the differences of bacteria seen with IBS. We know that two commercially probiotics are effective for treating IBS, so it is nice to know which bacteria they appear to push out. IBS and CFS are co-morbid, so these results likely applies to most CFS patients.

Real-time PCR analysis of enteric pathogens from fecal samples of irritable bowel syndrome subjects Teemu Rinttilä12Anna Lyra13Lotta Krogius-Kurikka1 and Airi Palva1

“According to the results, the studied clostridial groups (Clostridium histolyticum, Clostridium coccoides-Eubacterium rectale, Clostridium lituseburense and Clostridium leptum) represented the dominant faecal microbiota of most of the studied subjects, comprising altogether 29-87% of the total bacteria” [2006]

These author and other studies reports high levels of:

  • Staphylococcus aureus [2011]
  • Clostridium perfringens [2011]
  • Veillonella species (if constipation) [2005]
  • Low Lactobacillus sp (if diarrhea) [2005]
  • Clostridium coccoides [2005] (30 -50% of all bacteria [2006] )
  • Bifidobacterium catenulatum [2005]
  • Pseudomonas aeruginosa [2011]
  • Differences in  Coprococcus, Collinsella, and Coprobacillus [2007]

The detection was done by looking at RNA sequences. It should be noted that they tested only for 12 species. There may be other species involved. The likely reality is well expressed in this 2010 article, “data available from a .. do not reveal pronounced and reproducible IBS-related deviations of entire phylogenetic or functional microbial groups, but rather support the concept that IBS patients have alterations in the proportions of commensals with interrelated changes in the metabolic output and overall microbial ecology. ”

” The present study suggests that instability of intestinal microbiota may be involved in IBS.”[2005]. This matches my thinking that it is not a specific bacteria but a collection of cross-supporting bacteria from different species. If you kill one of them, another one that is willing to cooperate with this bad bacteria co-op will move in. You have to destroy the co-op. The coop may account for “the overall gene diversity was 15 % higher in the IBS samples than in the non-IBS samples”[2011]

For new comers to this blog, the two effective probiotics are: