Phosphatidlylserine: A review and alternatives for cognitive improvement

Phosphatidlylserine is commonly used to help with cognitive issues in Alzheimer’s Disease and other memory issues. According to Mayo clinic “improvements in memory lasted only a few months and were seen in people with the least severe symptoms.” Because chronic fatigue syndrome often manifest with memory issues, some MD’s may speculate that it could help with CFS. I encountered memory issues last time around with CFS and my SPECT scan was read as early Alzheimer’s disease by the radiologist (neurologist that I subsequently saw disagreed about Alzheimer’s).

So, a CFS MD suggesting that as an experiment seems reasonable. A check of pubmed found the following:

  • Phosphatidylserine – 13700+ hits
  • Phosphatidylserine chronic fatigue syndrome – NO hits
  • Phosphatidylserine fibromyalgia  – NO hits
  • Phosphatidylserine Parkinson – 22 hits
  • Phosphatidylserine Alzheimer – 78 hits
  • Phosphatidylserine brain trauma – 17 hits, none examined the impact of phosphatidlylserine supplementation.
  • Phosphatidlylserine supplementation – 136 hits

The most relevant article that I could find was Fish oil supplementation alters the plasma lipidomic profile and increases long-chain PUFAs of phospholipids and triglycerides in healthy subjects [2012]. It implies that taking fish oil may be as good as phosphatidlylserine. Since there has been no published studies that found that phosphatdylserine is low in CFS or FM, IMHO, the prescription of such to CFS patients is highly speculative.

My own experience

Taking Neem and Tulsi (6 – 00 capsules of each per day) causes a dramatic change of cognitive functions after 7 days.   The choice of those two was based on the overgrowth of certain families of bacteria reported from Australia and the effectiveness of Neem and Tulsi as good or better than conventional prescription antibiotics reported in Indian studies on PubMed.

Before I went on disability last time around, I found that I could moderate cognitive issues with the following items (until the anticoagulant impact resulted in easy bruising).

  • Piracetam (and other Racetams)
  • Grape Seed Extract
  • Fibrinolytics (dissolves fibrin): Nattokinease, Serrapetase, Lumbrokinease
  • Anti-inflammatories: Boswellia(Frankincense) , Myrrh
  • Turmeric

Recent Experience

I’m working at present as a Principal Software Engineer for a pre-IPO company with 40% growth/year. This last week has been — well — hectic and stressful, with four deployments schedules that were messy and with complications.  I was actually surprised on how well I handled this week with no cognitive fade out and actually awesome focus compared to several prior weeks. What I took everyday was actually a pretty simple and a short list.

  • Multivitamin with Mineral
  • Double dosage of Lactobacillus Reuteri (at bed time)
  • Ashwagandha (2 – 00 capsules per day) – morning
  • Piracetam (2 x 800 mg) –
  • 500 mg of Niacin (flushing variety)

I know that Ashwagandha acts as an antibiotic against some gut bacteria, although the original reason that I took it was as an adaptogen to moderate the stress response. The Reuteri is the most common lactobacillus in health mammals. I do not know how others may respond to this mixture. For me, after a week, I still find that cognitive function appear to be improving more — in small ways,  but detectable.