lassesen 2:46 pm on May 20, 2014

Probiotics and Histamines

I have been seeing some friends improve significantly from lowering histamine levels.

The question arises, which probiotics/bacteria increase or lower histamine levels?

Histamine release are part of the herx effect and thus reducing the level may reduce the severity of herx.

This list may be important for those that are probiotic sensitive and/or salicylates sensitive — the reason for these sensitivity could be the histamine dimension (speculation). There are some DNA association reported between salicylates and histamines sensitivities.

In some cases, it appears that one strain increases histamines and a different strain decreases histamine (i.e. Lactobacillus casei)

Increases
- Lactobacillus casei [2011]
- Lactobacillus delbrueckii subsp. bulgaricus [2011]
- Lactobacillus reuteri [2014] [2013] [2012]
- Bacillus licheniformis A7 [2013]
- Bacillus coagulans SL5 [2013]
- Morganella morganii [2013]
- Pseudomonas aeruginosa[2012]
- Citrobacter koseri [2012]
- Enterobacter spp [2012]
No Impact
- Lactobacillus acidophilus [2011]
- Lactobacillus lactis subsp. lactis [2011]
- Lactococcus lactis subsp. lactis [2011]
- Lactobacillus plantarum [2011]
- Lactobacillus sakei CRL1862 [2012]
- Lactobacillus plantarum Tensia[2012]
Decreases
- Bacteroides thetaiotaomicron [1999]
- Bacteroides fragilis [1999]
- Bifidobacterium adolescentis [1999]
- Escherichia coli [1999]
- Bifidobacterium infantis [2008]
- Bifidobacterium longum [2008]
- Lactobacillus rhamnosus (L. rhamnosus) GG (LGG(®) [2011]
- L. rhamnosus Lc705 (Lc705) [2011]
- Propionibacterium freudenreichii ssp. shermanii JS (PJS) [2011]
- Bifidobacterium animalis ssp. lactis Bb12 (Bb12) [2011]
- Lactobacillus casei [2012]
- Lactobacillus plantarum K-1 [2011]

MM 8:19 am on June 20, 2014

What are the signs of histamine sensitivity? I have a young child who is definitely salicylate sensitive (as well as other things), esp. behaviourally but he also has chronic congestion in his sinuses. I am wondering if it could be histamine issues.
I was recommended the Prescript Assist probiotics (for someone with amine/glutamate sensitivity/chronic congestion) as they are SBO’s but I have read some negative side affects of SBO probiotics.
If he is food chemically sensitive are there any probiotic strains I should be avoiding 😦
Any feedback/thoughts for a very overwhelmed mother Ken?
- lassesen 7:40 pm on June 20, 2014
  
  There is no easy answer, unfortunately, there are no accepted medical tests (and the tests that are there tend to be “read” according to the MD belief systems).
  In terms of symptoms — they overlap dozens of other autoimmune conditions — so there is not a clear signature. There is also the risk that this may be a side-effect of a different condition (in my book, a dysfunctional gut bacteria is high on the list of candidates).
  
  The easiest solution is to go on a low histamine diet and see if there are significant changes. For some (not all) people, taking DAO supplements (just google DAO supplement) will result in changes(reduction) of symptoms within a hour – which may be an easier spot check.
  
  Re: SBO — this concerns seems to be based on Victorian Hyper-cleanness belief. “Dirt will make you sick”. There are two pages worth reading:
  
  http://www.kitchenstewardship.com/2012/06/21/are-your-supplements-turning-into-deadly-pathogens-in-the-gut/
  http://www.raysahelian.com/soilorganisms.html “I have come across only one reliable human study regarding a particular soil organism called Mycobacterium vaccae, and hence it appears that any claims made for or against the use of soil organisms are premature and not based on any solid clinical evidence.”
  
  Prescript Assist has been thru several published studies with no side effects ascribed to SBO beliefs.
  
  I will try to get time to do another pass on probiotics/herbs and histamine production — the problem is that there is so very very little hard clinical studies in this area. I strongly suspect that gut bacteria is involved because of the wide variety of response people have (some tolerates X, some do not tolerate X) which using Osler’s reasoning suggests that there are different sets of bacteria in play for each person (which is what science tells us — gut and skin bacteria is a better identification than fingerprints or DNA (there was a nice study in Science where they could tell twins apart over long period of time but their bacteria but not by their DNA).
  - Kelly 8:34 pm on October 5, 2014
    
    This study showed that l. casei reduced histamine levels:
    
    http://www.ncbi.nlm.nih.gov/pubmed/22721727
    
    Confusing.
    - lassesen 4:22 pm on October 6, 2014
      
      One of the issues that I observed is that different strains of the same species (l.casei is the species).
      “Both strains were found to reduce histamine and tyramine accumulation.”
      
      The unfortunate aspect is that most probiotics do not list the strains (and if they do, often you cannot find any PubMed on those strains!). My rule of thumb is that if one strain goes the wrong way, then the conservative approach is to avoid the entire family unless you know for certain that you have the right strain.
      
      Simple example, I avoid E.Coli (as most people do!) except for the strain E.Coli Nissle 1917 (Mutaflor) which is the good apple in a barrel of rotten apples!
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Mats Lindström 8:13 am on June 13, 2015

Very interesting article! Is there any probiotic you prefer and recommand for histamin intolerans?

Regards
Mats from Sweden
http://www.wordpress. nevsaboutdisease.com
- lassesen 7:18 pm on June 14, 2015
  
  As a FYI: Avoid Filmjölk – it contains Leuconostoc mesenteroides,
  “The maximum histamine production was observed in … by Leuconostoc mesenteroides subsp. cremoris” http://www.ncbi.nlm.nih.gov/pubmed/24294229
  
  “Arla’s fil culture contains Lactococcus lactis subsp. lactis, Lactococcus lactis subsp. cremoris, Lactococcus lactis biovar. diacetylactis, and Leuconostoc mesenteroides subsp. cremoris.[2][3][9]” https://en.wikipedia.org/wiki/Filmj%C3%B6lk
  
  So the STRAIN in it is one known to produce histamine in large quantities.
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- lassesen 7:11 pm on June 14, 2015
  
  That is unfortunately a very complex question — partially due to lack of adequate research and worst, limited availabilities of pure strains.
  
  I have seen Yakult (bacterium Lactobacillus casei Shirota) eliminate or greatly reduce season allergies within 20 minutes. There is an alleged similar strain in Actimel – which I believe is available in Europe (https://en.wikipedia.org/wiki/Actimel ). Unfortunately, Actimel contains Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus salivarius subsp. thermophilus which are histamine producers.
  
  “Lactobacillus delbrueckii subsp. bulgaricus (TISTR 895) were found to produce BA… while TISTR 895 produced only histamine”
  http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2621.2011.02717.x/abstract
Mats Lindström 8:13 pm on June 14, 2015

OK, thanks – I understand what i should not take, but is there any probiotics you prefer? I have heard a lot of positive words about Vivomixx, but it is very expensive.
http://www.vivomixx.eu/eng/what-is-vivomixx.htm
- lassesen 12:56 am on June 15, 2015
  
  See https://cfsremission.wordpress.com/2015/06/15/vivomixx-probiotic-a-review/
Denis Strella 10:48 pm on October 6, 2015

Hi, Thank you very much for the information. I found an interesting brief of a study on the Cordis site: “It is the European Commission’s primary public repository and portal to disseminate information on all EU-funded research projects and their results in the broadest sense.”

They seem to fund studies of many kinds related to Amines. One of them tested Yogurt cultures. According to the study, the Yogurt cultures by Chr. Hansen (Denmark) are not Histamine producing. I apologize, that I am not really capable to judge the studies.

Personally, I have been taking several of the Natren products for 3 months. For the past month, I have been creating a 24 hour GAPS style “Yogurt” with the Natren Bifidobacterium infantis , NLS Strain. Anecdotally I have not noticed any physical Histamine style reaction. I strain the “Yogurt” to give me a “Greek” style which has as much of the Lacose, Galctose, and Whey removed yet still has a nice texture. Maybe a little creamier than a whipped cream cheese. I simply feel energized mentally after eating the “Yogurt” I will continue using this “Yogurt”

I just started eating a 24 “Yogurt” Fermented using a Solgar product with only the Lactobacillus acidophilus La5 and Bifidobacterium lactis BB-12 Strains. These are Chr. Hansen strains. I have not noticed any Histamine style reaction. I will see how it goes over the next couple weeks.

I made a 24 hour “Yogurt” using a new product which contains Lactobacillus fermentum ME-3. The resultant Greek style “Yogurt” immediately gave me what felt like a strong Histamine style reaction. Itchy scalp, and flushing. I tried it the next day, and had the same reaction. Discontinued that probiotic.

For my “Yogurt”, I use fresh starter for each batch. Some use some of their previous batch to make their new batches. I do not want to take the chance of any contamination with different Bacterium.

Thanks for letting me ramble opn.

http://cordis.europa.eu/result/rcn/84147_en.html

http://cordis.europa.eu/project/rcn/69962_en.html
- lassesen 4:33 am on October 7, 2015
  
  Many thanks for the information – every strain is different so sharing experiences with different strains is awesome!
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Anil van der Zee 1:20 pm on August 24, 2017

What are the best pro biotics that decrease histamines??
- lassesen 11:07 pm on August 24, 2017
  
  One school is to take low/no histamine probiotics.
  
  The other approach is to get ubiome done, determine which overgrowths are histamine producers and then reduce those by herbs, diet and/or antibiotics. That could include probiotics.. lactobacillus Fermentum is possible in some cases… But it really depends on the genus that are overgrowth
  - Anil van der Zee 11:15 pm on August 24, 2017
    
    Thank you for your answer. So there is no specific one that you can recommend?
    - lassesen 11:18 pm on August 24, 2017
      
      Unfortunately no. Without proper studies published, it becomes speculation
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