A Probiotic advertising as helping CFS Probiozym/HLC Mindlinx

A reader forwarded me a link to  Probiozym (in the US and Canada, it is called HLC Mindlinx). He indicated that he has heard that people are reporting an improvement from it. With CFS, I tend to be wary of “reported improvements” over the social networks — too often it turns out to be a placebo effect. I actually like placebo effects because often they reduce stress in the individual (which helps ameliorate symptoms).

So the key questions about this new offering should be:

  • Is there any objective evidence that it may be effective?
  • If the cost is above the price of “equivalent probiotics” is the premium warranted?

What is in this probiotic?

The product was developed in Norway. Unlike many probiotic manufacturers, they are open about the contents:

  • Lactobacillus rhamnosus NEU 427 50.0 mg
  • Lactobacillus crispatus NEU 458     50.0 mg
  • Lactobacillus acidophilus     50.0 mg
  • Bifidobacterium bifidum      2.5 mg
  • Fructooligosaccharides (FOS)          137,5 mg

On first look, it should help because it contains Bifidobacterium bifidum as cited in earlier posts [1],[2]. There is a species that I have not seen before, Lactobacillus crispatus. This and Lactobacillus Jensenii are predominant species found in the female lower genital tract. 13% of the genome is novel and not found in other species. It is considered to be one of the strongest H2O2-producing Lactobacilli.

Object Evidence

I found no PubMed articles on this probiotic (either name). There was nothing for either of the strains cited (NEU 427 or NEU 458). I focused on Lactobacillus crispatus and found no studies for the usual IBS, CFS, etc. All of the trials were treatment with bacterial vaginosis.

Cost Effectiveness

I found it on Amazon.com at $40 for 60 capsules which is comparable to the pricing of Align. IMHO, pricing is reasonable. Pricing is better than Seroyal Gammadyn Mn-Cu 30 Unidoses which contains only Lactobacillus crispatus (unknown dosage).


My reading on Lactobacillus Crispatus suggests that it is definitely worth a try — while I tend not to be favorable to Lactobacillus acidophilus containing probiotics — balancing everything, there is more likelihood for positive than negative consequences. A key factor is that it is a major hydrogen peroxide producer.

Unlike Lactobacillus case  and Lactobacillus delbrueckii subsp. bulgaricus (common in yogurts) which are histamine producers this appears to be low producers.