Crohn’s Disease: Update on Recent Research 2015-08-14

There are interesting factoids from reviewing 2015 articles on PubMed for Crohn’s Disease

  • IBD and Crohn’s are 2.18 times more likely to have anxiety disorders [2015]. It likely also the case for CFS
  • ” Taken together, our results introduce cellulose as a novel physiological factor that impacts host-bacterial-environmental interactions and alters the proinflammatory potential of AIEC.” [2015]. Cellulose food includes:
    • Broccoli, Brussels Sprout, Cabbage, Collard Greens, Kale, Horseradish, Rutabaga, Turnip, Chinese Cabbage, Cauliflower, Broccoli Rabe, Daikon, Bok Choy, Radish, Kohlrabi [Ref]
  • Volatile organic compounds (VOCs) in breath has been found to be a good predictor of disease state with Crohn’s [2015]. It is likely similar results would be seen with CFS and IBS – but studies need to be done.
  • “The traditional management of Crohn’s disease, which is based on progressive, step-wise treatment intensification with re-evaluation of response according to symptoms, does not improve long-term outcomes of Crohn’s disease and places patients at risk for bowel damage.” [2015] This is likely also true for IBS and CFS.
  • ” A linear dose-response relationship was found between dietary fiber and CD risk, and the risk of CD decreased by 13% (P < .05) for every 10 g/d increment in fiber intake. The results from this meta-analysis indicated that the intake of dietary fiber was significantly associated with a decreased risk of inflammatory bowel disease.” [2015]
    • Source is important: ” By source of fiber, cereal and, to a lesser extent, vegetable fiber were significantly associated with lower total mortality, while fruit fiber showed no association.” [2014]
  • Impact of music on CD – no impact [2015]
  • Siblings of patients with Crohn‘s disease exhibit a biologically relevant dysbiosis in mucosal microbial metacommunities.[2015]. i.e. if you have CD, sibling will likely off gut bacteria that is off. i.e. Fecal Transplants from siblings may not be ideal.
  • “The risk of IBD is significantly increased in first -, second-, and third-degree relatives of IBD-affected cases, with up to 12% of all IBD cases being family cases. The risk is particularly pronounced in young individuals” [2015]
  • “These results indicate children with IBD have less adaptability to stress.” [2015]
  • Alopecia [Hair Loss] secondary to anti-tumor necrosis factor-alpha therapy.
  • “These results indicate children with IBD have less adaptability to stress.” [2015]
  • ” Conclusion In summary, this is the first study to prospectively establish that both CD and UC patients are more prone to neuromuscular diseases” [2015]
  • Vitamin D: “The present literature appears to suggest that 25(OH)D concentrations of ≥75 nmol/l may be required for non-skeletal effects; however, further research on optimal levels is required.” [2015]
  • High amount of dietary fiber not harmful but favorable for Crohn disease. [2015]
  • “The remission rate with combined infliximab and SVD[semivegetarian diet] for newly diagnosed CD patients was 100%. Maintenance of remission on SVD without scheduled maintenance therapy with biologic drugs was 92% at 2 years.” [2015]
    • “SVD was highly effective in preventing relapse in CD.” [2010]

SVD Food Pyramid See full text article for more details

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  • “The utility of antibiotics was beneficial for patients with CD. Nevertheless, subgroup analyses indicated that treatment with ciprofloxacin alone was significantly efficient for CD patients with perianal fistulas.” [2015]
  • ” Early treatment strategy with immunomodulators is effective for inducing remission but no controlled data are available regarding long-term outcome. Combination therapy (anti-TNFs agents and immunosuppressors) is more effective than single therapy but there is a lack of long-term data and an increased risk of malignancy. The effect of mesalazine, metronidazole and azathioprine in reducing postoperative recurrence is not clinically relevant; biologics are effective, but the duration of treatment is unknown. New drugs are under investigation in order to find exit strategy for patients who no longer respond to biologics. Combination therapy set on anti-TNF-α is until now the best option both to achieve fistula healing and avoid recurrence.”[2015]