Core CFS Supplements

Supplements are a challenge for many CFSer. Often their criteria is the very subjective “if I don’t feel better, then they are not working”. If there is improvement and it takes 4 weeks, they may not be able to remember how they were, and thus perceive no improvement.

Supplements Shown to Improve CFS – Reported  by PubMed studies

I am filtering the studies to CFS, IBS and FM since they tend to be co-morbid. There are many supplements that were found to have no impact. I would recommend these supplements be used (and lab results increased to the desired level) before trying speculative supplements. Many supplements help other conditions but not CFS/FM/IBS – and in a few cases may make things worst. Be careful with items “that are good for you (general population)”, they may be contraindicted for CFS.

Very few things are reported to help all CFS patients — with the exception of Vitamin D.  To get to and keep at the recommended level, I find that I need to take 15,000 to 20,000 IU of Vitamin D3 per day. If you are low, it can take months even at that dosage to raise your level. Many things are reported low in CFS, and too frequently supplementation has no impact on symptoms.

In my next post I will look at items that help with “low level” hypercoagulation (which is reported in some 90% of CFSers). By low-level, I mean not sufficient to cause stroke or deep vein thrombosis (which a hematologist would deem to be “significant”), but sufficient to cause mental fog and fatigue.



Comment: a level of 50+ ng/mL appears to be a critical threshold for improvement, this is the level where parathyroid hormone stimulation occurs.


  • 40% are good responders, 60% are mild responders for B12 Injections [2015] – unbelievably, there appears to be only one study.

Coenzyme Q10



A non-essential amino acid.


Spezzata (pure Licorice – Glycyrrhia).


  • Improvement seen after 4 weeks [1997]
  • 60% response rate [2004]



NAC N-Acetyl-Cysteine (NAC) or acetylcysteine


Nicotinamide adenine dinucleotide (NADH). This is precursor for niacin

Dehydroepiandrosterone (DHEA)

  Evening Primrose Oil

To Be Avoided


Monosodium glutamate (MSG) is often added to food to improve favor.