Some readers may ask what is this about thick blood AKA micro clotting in COVID?
When I had my 2nd episode of CFS/ME, several papers had just be published by Dave Berg. He was not a MD nor a researcher. He owned and ran a laboratory that specialized in blood testing for infertility. The cause of one type of infertility is Hughes Syndrome or to put it into simple terms, thick blood. The blood is just thick enough that oxygen to the fetus is insufficient and results in spontaneous abortion. The modern treatment is low dosage of heparin (the body’s natural blood thinner) resulting in the fetus surviving. Heparin is not a single chemical, rather a bunch of different chemicals.
Dave Berg while working with MDs started to hear “oh by the way, Mrs. X while on heparin reported that her FM / CFS went away”. After hearing enough reports, he conducted a study of CFS patients (using his own labs and at his own expense) and found that most CFS had a detectable hyper coagulated state often connected to DNA mutations (i.e. inherited). These needed some external influence to become significant (i.e. an infection). A significant percentage went into remission from low dosage heparin alone. Others required heparin and either anti-virals or antibiotics.
As a side note, my mother had 2 sons and something like 7 miscarriages… I suspect “thick blood” was the cause. She did not have CFS.
Model
Some infection which prefers low oxygen levels has become established in the body. The infection manufactures chemicals to trigger coagulation (and thus lower oxygen levels to make your body friendly to it). Because of a person’s DNA mutations, not all of the coagulation is cleaned up — resulting in thick blood. At my worst, it took 12 tries at various locations to get one blood sample out of me, things were that thick!
With heparin or other appropriate blood-thinners, the oxygen increases and with some infections, the increased oxygen is sufficient to suppress the infection (which likes low oxygen levels), thus stopping further coagulation. The “infection” may be in tissue, or a combination of bacteria in the gut (or microbiome), it may not be detected in the blood.
My Experience
On my 2nd episode with CFS, the MD sat on the wall about coagulation — doing a “I will think about it”. I decided to try a simple experiment: I got a bottle of aspirin and read what the maximum dosage allowed was (and for how long) and then did it. About 7 days later I was climbing the ways with energy and improved thinking (I crashed fast once I stopped). The MD saw the changed and ordered extensive coagulation panels from Berg’s lab (later the MD sent to a local lab and got similar results — just to make sure that Berg’s lab was not misreporting). I was put on low dosage heparin and once my DNA results came back, I found that my DNA defect could be treated with Piracetam and Turmeric.
At the start of my 3rd episode, I hit the anticoagulants increasingly to keep me working while my new MD was running the mountain of exclusionary tests required before a CFS diagnosis could be given (as well as having symptoms for 6 months). I knew what was happening — the MD did not believe me until the SPECT scans came back. I stopped the anticoagulants as soon as easy bruising started to happen — and totally crashed 3 days later. Antibacterial/antivirals were needed.
Coagulation is complex with many steps in the process. It takes just one step to over-produce or under-produce to create a problem. The typical mistake that people make is to address only the step that aspirin impacts (platelets)– that is usually insufficient (and if you take too many substances that impacts that step, you have a major risk of serious bleeding). Always consult with your MD before starting any supplements.
With that said, I will give my list of supplements which are available (in the US without prescription) and what each does according to PubMed. I will not try to explain all of the complexities or terms (sorry — that’s another topic, use wikipedia)
Thick Blood Supplements
Alpha Lipoic Acid
- Lowers CD62P platelet expression http://www.ncbi.nlm.nih.gov/pubmed/22228743 (2012)
- Reduces CRP levels by 19% http://www.ncbi.nlm.nih.gov/pubmed/21908204 (2012)
- Decreases symptoms of neuropathy and neuropathic deficit http://www.ncbi.nlm.nih.gov/pubmed/20519180 (2010)
- Decreases fibrinogen, factor VII, vWF, and triglycerides http://www.ncbi.nlm.nih.gov/pubmed/11474472 (2001)
- Decreases tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) http://www.ncbi.nlm.nih.gov/pubmed/21593803 (2011)
- Improves blood flow and nerve function http://www.ncbi.nlm.nih.gov/pubmed/11474472 (2001).
- Reduces plasma levels of free fatty acids (FFAs), triglyceride (TG), total cholesterol (T-Chol), low density lipoprotein-cholesterol (LDL-Chol), small dense LDL-Chol (sd-LDL), oxidized LDL-Chol (ox-LDL-Chol), very low density lipoprotein-cholesterol (VLDL-Chol) http://www.ncbi.nlm.nih.gov/pubmed/21593803 (2011)
Boswelia Gum
Gum-resin extracts of Boswellia serrata have been traditionally used in folk medicine for centuries to treat various chronic inflammatory diseaseshttp://www.ncbi.nlm.nih.gov/pubmed/22457547 (2011). It has been found to have antibacterial http://www.ncbi.nlm.nih.gov/pubmed/22422529 (2012), anti-arthritic http://www.ncbi.nlm.nih.gov/pubmed/21479939 (2011), anti-edemateous http://www.ncbi.nlm.nih.gov/pubmed/21855244 (2011), antioxidant, antiplatelet and anticoagulant(equivalent to heparin)http://www.ncbi.nlm.nih.gov/pubmed/21771654 (2011). positive effects of BEs in some chronic inflammatory diseases including rheumatoid arthritis, bronchial asthma, osteoarthritis, ulcerative colitis and Crohn’s disease have been reported http://www.ncbi.nlm.nih.gov/pubmed/20696559 (2010).
- Inhibited clotting factors Xa and Xia
- Inhibited ADP induced platelet aggregation
- Major increase of coagulation time
- Major increase of prothrombin time
- Major increase of activated partial thromboplastin time
- Decrease of TNF-alpha, IL-1, IL-2, IL-4, IL-6 and IFN-gamma http://www.ncbi.nlm.nih.gov/pubmed/20696559 (2010)
- Reduces CPR levels http://www.ncbi.nlm.nih.gov/pubmed/22017619 (2012)
Bromelain
Coagulation-inhibiting effects http://www.ncbi.nlm.nih.gov/pubmed/2203073 (1990)
- Has anti-edema, anti-inflammatory, and coagulation-inhibiting effects
- Increases serum fibrinolytic activity, reduces fibrinogen synthesis, and directly degrades fibrin and fibrinogen[7].
- Impact plateaus at 12-16 hours http://www.ncbi.nlm.nih.gov/pubmed/7529614 (1994)
- enhancement of the serum fibrinolytic activity,
- inhibition of the fibrinogen synthesis,
- direct degradation of fibrin and fibrinogen http://www.ncbi.nlm.nih.gov/pubmed/2203073 (1990)
- acts as fibrinolysis enzyme activator http://www.ncbi.nlm.nih.gov/pubmed/7199897 (1981)
Centella Asiatica [Gotu kola]
This is used in Spain
- “The anti-thrombotic active constituents from Centella asiatica. [2007]”
- “Thus, C. asiatica was shown to promote blood circulation to remove blood stasis. Consequently, C. asiatica is a useful medicinal plant for the prevention of lifestyle-related diseases such as hypertension, cardiopathy and cerebral apoplexy caused by arteriosclerosis.”
Coenzyme Q10
- Reduces blood clotting http://www.ncbi.nlm.nih.gov/pubmed/20617421 (2010)
Ginseng
Acts similar to aspirin for coagulation
- Supplementation helped 56% http://www.ncbi.nlm.nih.gov/pubmed/15889950 (2005)
Grape Seed Extract
Grape seed extract is rich in proanthocyanidins. Proanthocyanidins are available from other supplements (cranberry juice, cider). It may or may not offer protection for glutamate excitotoxicity (depends on grapes being used) http://www.ncbi.nlm.nih.gov/pubmed/21283677 (2011).
- decrease in uPA and PAI-1 activities and thus decreased fibrinolytic activity http://www.ncbi.nlm.nih.gov/pubmed/19640694 (2010)
- inhibitory effect on platelets http://www.ncbi.nlm.nih.gov/pubmed/15567462 (2005) http://www.ncbi.nlm.nih.gov/pubmed/16160595 (2005)
- With L-arginine reduces fatigue http://www.ncbi.nlm.nih.gov/pubmed/20386475 (2010)
- Increases antithrombin activity http://www.ncbi.nlm.nih.gov/pubmed/20726345 (2010)
- Decreased fibrinolytic activity, Decreased cell-surface plasmin activity. [http://www.ncbi.nlm.nih.gov/pubmed/19640694 (2010) http://www.ncbi.nlm.nih.gov/pubmed/3161536 (1985)
- Reduces thrombus formation, inhibitory effect on platelets http://www.ncbi.nlm.nih.gov/pubmed/15567462 (2005)
Licorice
Spezzata (pure Licorice – Glycyrrhia). http://www.ncbi.nlm.nih.gov/pubmed/9196073 (1997)
- Increases plasma recalcification, thrombin and fibrinogen clotting times
- Reduces thrombin-induced, but not collagen-, PAF- or convulxin-induced platelet aggregation.
Lumbrokinease
- antithrombotic http://www.ncbi.nlm.nih.gov/pubmed/12483186 (2002)
- digested fibrinogen and inhibited platelet adhesion http://www.ncbi.nlm.nih.gov/pubmed/1960890 (1991)
- fibrinogen decreased significantly. Inhibition of intrinsic coagulation pathway and the activation of fibrinolysis via an increase of t-PA activity[ http://www.ncbi.nlm.nih.gov/pubmed/11321442 (2000)
Nattokinase
Nattokinase is from a fermented-soya desert food in Japan called Natto.
- decrease of red blood cell aggregation
- lower shear-viscosity of blood cells http://www.ncbi.nlm.nih.gov/pubmed/16899918 (2006)
- cleaves cross-linked fibrin http://www.ncbi.nlm.nih.gov/pubmed/8593442 (1995)
- Increased activated factor VII levels http://www.ncbi.nlm.nih.gov/pubmed/9491273 (1997)
- inactivates plasminogen activator inhibitor type 1 and then potentiates fibrinolytic activity http://www.ncbi.nlm.nih.gov/pubmed/12850244 (2003)
Maximum dosage: 4000 Fibrin Units http://www.pureprescriptions.com/expert_opinion/Nattokinase-Information.asp http://digitalnaturopath.com/treat/T447441.html
Piracetam
For coagulation http://www.ncbi.nlm.nih.gov/pubmed/8457235 (1993), reduces
- von Willebrand’s factor
- inhibition of thromboxane synthetase
- inhibition of anti-thromboxane A2
- 30-40% reduction in plasma levels of fibrinogen
- reduces cell membrane deformability (red cells, white cells and platelets)
Turmeric
The active ingredient of this kitchen spice is curcumin. Turmeric appears to be more effective than curcumin, the extract[1].
- Increases fibrinolytic activity http://www.ncbi.nlm.nih.gov/pubmed/21071923 (2010)
- Reduces high level of fibrinogen http://www.ncbi.nlm.nih.gov/pubmed/10802125 (2000)
- Inhibit platelet aggregation, increases coagulation. time http://www.ncbi.nlm.nih.gov/pubmed/12575127 (2000)
Evening Primrose Oil
Depending on your DNA, it may help or make things worst.
- Increases in fibrinogen, factor VII, vWF, triglycerides, and cholesterol and a significant decrease in high-density lipoprotein http://www.ncbi.nlm.nih.gov/pubmed/11474472 (2001)
- Improves blood flow http://www.ncbi.nlm.nih.gov/pubmed/11474472 (2001)
- Decreased platelet count http://www.ncbi.nlm.nih.gov/pubmed/19783511 (2009)
- Effective in some CFS patients http://www.ncbi.nlm.nih.gov/pubmed/8616424 (1996)
- No significant difference in a long term study http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907931/?tool=pubmed#BMJ_1101_I8 (2008)
1.1.1 Sunflower Oil
- Increases in fibrinogen, factor VII, vWF, triglycerides, and cholesterol and a significant decrease in high-density lipoprotein http://www.ncbi.nlm.nih.gov/pubmed/11474472 (2001)
More readings on thick blood
- https://atomic-temporary-42474220.wpcomstaging.com/treatment/thick-blood-clots-dimension-of-cfs-etc/hemex-protocol-and-dave-berg/dave-berg-cfs-radio-program-1999-08-29/
- https://atomic-temporary-42474220.wpcomstaging.com/treatment/thick-blood-clots-dimension-of-cfs-etc/
- https://atomic-temporary-42474220.wpcomstaging.com/treatment/thick-blood-clots-dimension-of-cfs-etc/hemex-protocol-and-dave-berg/transcript-of-townhall-with-dave-berg-hemex-labs/comment-page-1/
- https://atomic-temporary-42474220.wpcomstaging.com/treatment/thick-blood-clots-dimension-of-cfs-etc/hemex-protocol-and-dave-berg/townhall-with-david-berg-3/
- https://atomic-temporary-42474220.wpcomstaging.com/treatment/thick-blood-clots-dimension-of-cfs-etc/hemex-protocol-and-dave-berg/dave-berg-talk-4/
- https://atomic-temporary-42474220.wpcomstaging.com/treatment/thick-blood-clots-dimension-of-cfs-etc/hemex-protocol-and-dave-berg/