Resveratrol is an extract from the skin of grapes, blueberries, raspberries, and mulberries. This week’s edition of New Scientist found suggested significant benefits for Alzheimer’s disease, with dosages of up to 1 gm/day showing no ill effects [2015]. I view all illnesses with significant cognitive issues likely being more extreme cases of the CFS mechanisms. On the flip side, the same study found “Brain volume loss was increased by resveratrol treatment compared to placebo.” (“A working hypothesis [of brain volume loss] is that the treatments may reduce inflammation (or brain swelling) found with Alzheimer’s.” [2015]

• Resveratrol protects β amyloid-induced oxidative damage and memory associated proteins in H19-7 hippocampal neuronal cells[2015].
• Neuroprotective effects of resveratrol in Alzheimer disease pathology[2014].
• Neuroprotective action of resveratrol.[2014]
• etc 100 + on this and neurological impact 

I use resveratrol/grape seed extract regularly based on it’s characteristics for coagulation, some 19 studies. For example, One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease [2012]. One of the reasons is that it have a plasma half-life of 9 hr [2004] longer than aspirin (which also inhibits platelet aggregation) which is 20 minutes [2004]

• Antithrombin effect of polyphenol-rich extracts from black chokeberry and grape seeds [2013].
• Antithrombotic effect of grape seed proanthocyanidins extract in a rat model of deep vein thrombosis.[2011]

My usual preference is “whole source” (i.e. grape seed, blueberries, etc) instead of extracts — because nature likely has auxiliary compounds that are also helpful. The extract usually comes from attempts to commercialize the effective whole source.

Botttom line: Resveratrol / grape seed extract is a positive for CFS as I mentioned in my earlier post.

• decrease platelet aggregation, increase platelet-derived NO release, and decrease superoxide production [2001]
• strong antioxidant activity, antibacterial, antiviral, anticarcinogenic, anti-inflammatory, anti-allergic, and vasodilatory actions, inhibit lipid peroxidation, platelet aggregation, capillary permeability and fragility [2000]

With a daily dosage of 1000 mg/day being found to be safe and in the case of Alzheimer’s, effective – I would suggest discussing with your medical professional a dose of 500 mg/day which is well above the typical dosages recommended on bottles.