BIFIDO|MAXIMUS Histamine-Free and D-Lactate Free Probiotic – Review

This is a new on the market probiotic. In fact, shipped first only a few days ago (announcement). There are no PubMed studies on it yet (which I hope will change soon…). If what it claims is true:

  • Histamine-Free and
  • D-Lactate Free

This should result in the volume of D-Lactate producing and Histamine producing bacteria in the stomach to drop and for at least two probable subsets of CFS – improvement of symptoms (and for a few possible remission). I do not yet found any studies on Miyarisan (clostridium butyricum) and histamines on PubMed, nor clear results on D-Lactate — but suspect that Miyarisan is likely complementary to Bidio|Maximus.

So what is in it?

  • Bifidobacterium longum (40%)
    • Bifidobacterium infantis and Bifidobacterium longum reduces histamine levels [2008]
  • Bifidobacterium bifidum/Bifidobacterium infantis (20%)
    • Bifidobacterium infantis and Bifidobacterium reduces histamine levels[2008]
    • “Increases in the numbers of eosinophils and neutrophils in nasal cavity lavage fluid collected after a pollen challenge were almost completely suppressed by the Bifidobacteriumbifidum G9-1 treatment, whereas those in mast cell mediators, histamine, and cysteinyl leukotrienes were not.” [Sep 2015]
      • Earlier studies showed it reduce allergy and was speculated to be reduction of histamine. It is now unclear if this is the case. On the plus side, it is not reported to increase histamine (a feature claimed)
  • Lactobacillus rhamnosus (20%)
    • “The strains are neither haemolytic nor producer of biogenic amines such as histamine, putrescine, cadaverine and tyramine.”[May 2014]
    • “[Lactobacillus rhamnosus: strains: ] LGG and Lc705 were observed to suppress genes that encoded allergy-related high-affinity IgE receptor subunits α and γ (FCER1A and FCER1G, respectively) and histamine H4 receptor” [2011]
  • Lactobacillus salivarius (10%)
    • “isolates were classified into 5 different LAB species: Lactobacillus salivarius, Lactobacillus reuteri,Lactobacillus johnsonii, Pediococcus acidilactici, and Lactobacillus paralimentarius. None of the isolates produced tyramine or histamine.” [2012]
    • “detection of four genes involved in the production of histamine (histidine decarboxylase, hdc), tyramine (tyrosine decarboxylase, tyrdc) and putrescine (via eithers ornithine decarboxylase, odc, or agmatine deiminase, agdi). From examined strains only two chicken isolates (L. reuteri 14K; L. salivarius 15K) had no harmful β-glucuronidase, β-glucosidase activities connected with detrimental effects in the gastrointestinal tract and together no amino acid decarboxylase activities and no genes associated with biogenic amines production” [2014]
  • Lactobacillus gasseri (10%)
    • [Article] heat killed Lactobacillus gasseri TMC0356 (TMC0356) can modify the immune response in the elderly.
    • Reduce allergies (which can be ascribed to histamine reduction but could be other things) [2008] [2009] [2012]

Unfortunately no strains were provide (always on my wish list for probiotic). So time to summarize what each is known to do frequently (depending on strains) is shown above. During the research, I discovered that some strains of Lactobacillus reuteri do not produce histamines — L.Reuteri is the most common lactobacillus in a healthy human gut and also very low in CFS patients. This implies that the reduction of the L.Reuteri population would result in histamine increase from the bacteria that takes its place.  If there is production of D-lactate by L.Reuteri, I was unable to find on PubMed.

This is definitely worth trying for migraines, a lot of literature has association of histamines and migraines (361 hits on PubMed). For CFS and FM, it is likely a good candidate for some subsets (and to determine if you are in that subset, you need to take it).

The cost ($50/month) is like too much for those CFS/FMers on SSI to try as an experiment. I am hoping that some clinical trials for FM and CFS will start soon.

If you can afford it and inclined to try it, may I request that after 30 days you post your experience here as comments (both positive and negative). While your reports will be anecdotal, they will help other patients to determine if it is worth cutting other supplements to try this.


It has been 2 years since this post and no one has delivered a report. I infer that “no significant change” has been people’s experience.

My thought has evolved that it is overgrowth of other genus that is the root of the histamine issue. A reader wrote that their histamine issues disappeared after a course of Erythromycin (macrolide).