Ideal Lactobacillus Probiotics for CFS

A reader wrote earlier this month:

“I recently started taking high dose (about 150 billion) probiotics from Custom Probiotics. It’s their D Lactate-free probiotics made up of 5 different bacteria strains.

  • L. Salivarius
  • B. Lactis
  • B. Bifidum
  • B. Infantis
  • B. Longum
    The psoriasis has improved incredibly in the 16 days I’ve been taking it.”

I believe that the over production D-Lactate is likely a factor for many CFS patients (and excessive histamines for others). This lead to my recommendation to take  Miyarisan (Clostridium butyricum) because it converts lactic acid to butyric acid. An additional factor for some patients is the desired to be histamine-free. This is reasonable, one patient in the uBiome result had Morganella, a major histamine producer. In addition to the one from Custom Probiotics, there is BIFIDO|Maximus which adds Lactobacillus rhamnosus and Lactobacillus gasseri.

So based on their claims, we have three species, see The Dilemma of D-Lactate Free Probiotics – they do not work 😦

  • Lactobacillus Gasseri
  • Lactobacillus Rhamnosus
  • Lactobacillus Salivarius

Unfortunately evidence suggests they do not change d-lactate levels.

In addition to this, the KyberKompakt Pro report found low levels of Hydrogen Peroxide producing Lactobacillus species. This adds an additional constraint to selection.


  • “several L. plantarum strains, have been shown to produce different antimicrobial agents such as organic acids, hydrogen peroxide” [2016]
  • Lactobacillus gasseri CRL1421 and Lactobacillusgasseri CRL1412, which share some probiotic properties, produce H2O2,” [2006]
  • “Lactobacilli were identified in 215 (71%) of 302 women. The 3 predominant species identified were L. crispatus (32%), L. jensenii (23%), and lactobacillus 1086V (15%). Among these species, 95%, 94%, and 9%, respectively, produced H2O2. Surprisingly, L. acidophilus was not detected in any women. ” [1999] [2012]
  • Other H2O2-producing species or strains have been proposed to have probiotic properties, such as Bifidobacterium bifidum (6) and Lactobacillus johnsonii (7), or are prevalent in the commensal vaginal microbiota, such as Lactobacillus crispatus, Lactobacillus jensenii, and Lactobacillus gasseri (8). [2014]

The last constraint is not killing E.Coli

  • ” strains L. plantarum 106 and 107 were the most active microorganisms against E. coli” [2016]

Kyo Dophilus 9

This probiotic almost hits a sweet spot containing only L.Gasseri, L. rhamnosus (H2O2 producer) and Bifidobacteria:

  • L. gasseri B,
  • L. rhamnosus,
  • L. gasseri M,
  • B. bifidum,
  • B. longum M,
  • B. longum B,
  • B. infantis,
  • B. breve
  • B. lactis

An alternative is Kyo-Dophilus contains Lactobacillus gasseri, Bifidobacterium bifidum and Bifidobacterium longum. It is unclear if it contains one or two strains of L.Gasseri.

Bottom Line

Oral probiotics containing either Lactobacillus crispatusLactobacillus jensenii, Lactobacillus vaginalis could not be found.

  • Lactobacillus Reuteri – all human strains produce histamine 😦
  • Lactobacillus Delbrueckii — weak producer of histamine [1995] [1998]