Enterogermina – Update

In my prior post on Enterogermina probiotic. I have since been directed to an online version of their package insert (Latest revision of the package leaflet by the Italian Drug Agency: December 2008). And noticed the following statements:

  • “Enterogermina is used to cure and prevent intestinal bacterial flora disorders. Enterogermina restores the intestinal flora balance upset during treatment with antibiotics or chemotherapeutic products, helping to correct consequent dysvitaminosis conditions (that is, anomalous vitamin production and assimilation). “
  • “During treatment with antibiotics, we recommend Enterogermina be administered during the interval between antibiotic administrations.”
  • Enterogermina bottles have a shelf life of 2 years. Enterogermina capsules have a shelf life of 3 years.
  • It is manufactured in France and Italy. It is available in India Clinical Study in India. Morocco. UAE. Mexico. Trinidad and Tobago. Pakistan. (It is imported from France). And ebay (with very high shipping cost, hopefully multiple packages at the same shipping cost) –
    • HINT: Any CFSer in Italy care to set up an ebay account that offers it with reasonable shipping cost???? It does not need to be sent “Express” but can be sent via parcel post.
    • Sinuberase” in Mexico contains Bacillus clausii in similar packages.


Going over to MicrobeWiki, we find:

  • Bacillus clausii is found in the soil where it can reduce nitrate to nitrite.”
  • “strains from Enterogermina were found to release antimicrobial compounds and modulate immune activity by increasing production of secretory immunoglobin A.[IgA]”
    • “IgA limits penetration of commensal bacteria back through the epithelium and shapes the density of different bacterial species in the intestinal lumen”[2007]
  • “846 base pair erm-related gene in Bacillus clausii that confers resistance to certain antibiotics… such as erythromycin, azithromycin, spiramycin, lincomycin, clindamycin, and pristinamycin I.” – Macrolides and aminoglycosides [2014]
  • B. clausii in Enterogermina can in fact colonize for brief periods of time on the intestinal wall of the gut, and provoke immune response in mice to rid of pathogenic bacteria.”
  • “originally noticed as a novel species upon the characteristics of ability to hydrolyze casein, ability to reduce nitrate, and ability to grow at 50°C. Further tests showed Bacillus clausii were able to use multiple sources of carbon including: L-aribose, xylitol, galactose, dulcitol, sorbitol, methyl a-D-mannoside, mannose, N-acetylglucosamine, D-tagose, 2-ketogluconate.” i.e. the above sources should be taken with it to encourage further growth of the probiotics.