A reader in Spain forwarded to me an article just published days ago, “Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome “. As expected, there was no outstanding results except for mtDNA (Mitochondrial DNA). mtDNA is inherited from the mother only, thus for some symptoms — a daughter’s symptoms may be the same as her mother in general.
The conclusions were
“We did not observe a significant association of mitochondrial DNA genome variation with either susceptibility or resistance to ME/CFS. We did not detect any significant difference in level of heteroplasmy between cases and controls. Using a cohort of 193 ME/CFS cases and 196 controls, at 5 % FDR we observed eight mtDNA SNPs to be associated with 16 symptom categories and three haplogroups associated with six symptom categories, suggesting that the mitochondrial genome of an individual with ME/CFS can affect the type and severity of particular symptoms.”
How to Check Yours!
I have reproduced the table 4 in the article and added a column showing my own SNPs below. For myself, the SNPs and symptoms were accurate! Below I explain how you can test your own DNA against this study.
|Nucleotide position||Symptomatic allele||p value||q value*||Symptom||Type||Survey||23AndMe||Click Below|
|150||T||0.000196||0.01373||Accomplished less emotional||–||SF-36||C||23 and me|
|150||T||8.94E-05||0.005944||Less time for work||–||SF-36||C|
|150||T||0.00048||0.03358||Didn’t work as carefully||–||SF-36||C|
|930||G||9.71E-05||0.006795||Difficulty performing work||–||SF-36||G||Match||23 and me|
|1719||A||3.80E-06||0.0002661||Inflammatory distress||Cluster||DePaul||G||23 and me|
|1719||A||6.54E-05||0.00458||Neuro inflammatory distress||Cluster||DePaul||G|
|1719||A||0.000161||0.01129||Sensitivity to bright lights||Distress||DePaul||G|
|1719||A||0.000301||0.02108||Sensitivity to bright lights||Frequency||DePaul||G|
|3010||A||0.000173||0.01208||Sleep in day, awake all night||Frequency||DePaul||G||23 and me|
|3010||A||0.000226||0.01582||Sleep in day, awake all night||Distress||DePaul||G|
|5147||G||0.001175||0.04114||Difficulty performing work||–||SF-36||G||Match||23 and me|
|16093||T||0.000206||0.0144||Accomplished less physical||–||SF-36||T||Match||23 and me|
|16223||T||0.00076||0.0266||Sensitivity to bright lights||Frequency||DePaul||C||23 and me|
|16223||T||0.000885||0.03098||Neuro inflammatory distress||Cluster||DePaul||C|
|16519||C||0.000125||0.008729||Gastrointestinal distress||Cluster||DePaul||T||23 and me|
- Log on to 23Andme.com
- Click the link on the far right after logging on
- A page will be rendered like the one shown below
Look at the Nucleotide position in the table and “Position” on this page. Then look to the right to see your value. I have a value of “C” which is not the same as the symptomatic allele — hence it is likely not a symptom for me (and it is not).
Haplogroup and Symptoms
“All of the significant associations were with symptoms related to joint pain, bloating, or “feeling dead” after exercise. Haplogroup J showed a protective effect against all metrics of joint pain and individuals belonging to haplogroup U reported less severe bloating and had lower bloating distress scores compared to other haplogroups. On the other hand, ME/CFS individuals with haplogroup H tended to be more susceptible to “feeling dead” after exercise than other haplogroups.”
I am in the R1 haplogroup so there was no findings for me.
The SNPs likely impacts how the body responds to shifts of the microbiome (effectively a chemical factory with many many chemicals) and are not a direct cause of the symptoms. The shifts are unique but with a lot of commonality — for example, some of these SNPs could be connected to D-Lactic Acidosis, a condition that could arise from many different bacteria in the microbiome.