lassesen 4:00 am on April 28, 2017  

High Blautia — seen in some CFS Microbiomes

A long time (almost 2 decades) CFS friend got his microbiome done by ubiome.com. I will be writing some more posts on his ubiome and history, but to get things started I want to look at the subset that have high Blautia.

As with most CFS patients, there is a relative lower level of Firmicutes — here it is under 62% are Firmicutes (ME/CFS averaged 58%, healthy controls 65% — see this post). “We observed that bacterial diversity was decreased in the ME/CFS specimens compared to controls, in particular, a reduction in the relative abundance and diversity of members belonging to the Firmicutes phylum.” [2016]

  • “Within the Firmicutes, at the family level, Ruminococcaceae were lower in the ME/CFS samples (16 vs. 11 % in ME/CFS and healthy individuals respectively)”[2016] — Ruminococcaceae are part of  Clostridium XIVa which was covered in this post.

d

Moving down to the Genus level we see similar to some other patients (see this post), especially the high Blautia — also seen with Patients “R” and “Q” See below. Other CFS patients had just 2-5%.

g1

A second one done a few weeks apart, show similar results

g2

Patient Q

example9

Patient R

examplea

Reducing Blautia

Blautia genus (under Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae) has become a dominant Genus and consist of dozens of species. Note that it was classified under “ruminococcus”(by appearance) until RNA studies found that while it looks alike but was different. In italic and red are items to avoid, bold are items to take.

  • “some bile acids have been shown to exhibit antimicrobial activity….bactericidal activities to Blautia coccoides” [2017]
  • “sodium butyrate …. elevated the abundances of the beneficial bacteria Christensenellaceae, Blautia and Lactobacillus.”[2017]
  • “safflower oil…increased abundance of Blautia,[2016]
  • Japanese traditional dietary fungus koji Aspergillus oryzae functions as a prebiotic for Blautia coccoides through glycosylceramide: Japanese dietary fungus koji is a new prebiotic [2016].
  • “Bacillus subtilis…the relative abundance of Alistipes, Odoribacter, Ruminococcus, Blautia and Desulfovibrio were higher” [2016]
  • “Metformin and berberine.…were markedly increased” [2015] [2016]
  • “Resistant starch (RS) …  Roseburia, Blautia, and Lachnospiracea incertae sedis were decreased.” [2015] [2016][2014]
  • ” Blautia, Roseburia and Coprococcus were significantly enriched following treatment with hydrolyzed casein formula supplemented with Lactobacillus rhamnosus GG” [2016]
  • “Blautia and Staphylococcus) significantly increased after Lactobacillus plantarum P-8 consumption,” [2015]
  • “Lactobacillus salivarius Ls-33…Blautia coccoides_Eubacteria rectale group and Roseburia intestinalis, were significantly increased” [2013]
  • ” least 24 billion viable Lactobacillus paracasei DG …the Clostridiales genus Blautia (P = 0.036) was decreased;”
  • “High grain diet …altered the colonic mucosal bacterial communities, with an increase in the abundance of genus Blautia and a decrease in the abundance of genera Bacillus, Enterococcus, and Lactococcus.”
  • “antimicrobial effect observed for the grape seed polyphenols, particularly against Bacteroides, Prevotella and Blautia coccoides-Eubacterium rectale.” [2015]
    • “Subjects with regular consumption of red wine (mean = 100 ml/day) had lower serum concentrations of MDA and lower fecal levels of… blautia”[2015]
  • “positive associations between flavone intake and Blautia,” [2015]
  • “A negative association was found between the intake of pectins and flavanones from oranges and the levels of Blautia coccoides” [2014]
  • “Rosemary Extract …increased the Blautia coccoides and Bacteroides/Prevotella groups and reduced the Lactobacillus/Leuconostoc/Pediococccus group in both types of animals.” [2014]
  • ” All treatments [a daily dose of 60 g of whole-grain barley (WGB), brown rice (BR), or an equal mixture of the two (BR+WGB)] increased microbial diversity, the Firmicutes/Bacteroidetes ratio, and the abundance of the genus Blautia in fecal samples.”
  • “At the end of the 2-week omega-3 rich diet, we identified a striking reduction in Faecalibacterium, and a remarkable increase in Blautia” [2016]

Bottom Line

There was a number of common things between this post decreasing Blautia and the last post increasing Clostridium XIVa.

  • Grapes and/or Grape seed
  • Bile Acid supplementation
  • Apple Pectin and Oranges (for it’s specific flavanones)

On the other side, we saw study after study that lactobacillus probiotics increases blautia.

  • NO LACTOBACILLUS PROBIOTICS
  • No Bacillus subtilis probiotics (likely no bacillus of any species)
  • No sodium butyrate
  • No safflower oil.(Change to Grape Seed oil for cooking?)
  • Reduce grain intact