Increasing Alistipes Putredinis

Another low bacteria from  Ian Lipkin et. al [2017] study  [Index to all posts on Study] was Alistipes putredinis was formerly known as Bacteroides putredinis (Weinberg et al., 1937) [2003]. Like the prior two bacteria, it is a butyrate producer. It is in the the lysine pathway [2014]

  • “There was one isolate of Bacteroides putredinis resistant to chloramphenicol” [1999]
  • “Adding meat back in to a vegan diet caused an immediate increase in the bacteria (Bilophila wadsworthia, Alistipes putredinis and species in the genus Bacteroides) that grow with exposure to bile, which increases when a person eats more fat.” [From Nature]
  • Alistipes putredinis, and Eggerthella spp. were associated with cruciferous vegetable intake” [2009]

We have very little information on increasing this one, but there is a hint that should be followed up.

Looking at Butyrate Producers

There are four main pathways (acetyl-CoA pathway, orange; glutarate pathway, blue; 4-aminobutyrate pathway, pink; lysine pathway, grey)[2014]. Shown below are these pathways.

One is missing, the lactate->butyrate path which is used by Clostridium Butyricum (while listed below — is blank).


This raises the question: is the low level due to the low level the “intake food the bacteria uses to produce butyrate”?? That is:

Suggested Clinical Trials

As with the last post, 10 patients have their microbome measured before and then 2 weeks after the end of the interventions listed below. There should be a separate trial for each of the following.

  • Lysine supplementation
  • Valine supplementation
  • Leucine supplementation
  • Isoleucine supplementation

Additional trials could be done on specific cruciferous vegetables.

Bottom Line

Eat cruciferous vegetables! But no broccoli (see earlier post)! Supplementation with amino acids listed above could help — but we need trials.

THIS IS NOT MEDICAL ADVICE — this post is an education summary of what has been reported on PubMed. Always consult with a knowledgeable medical professional before changing diet, supplements and prescription drugs.