Metformin – low dosages may help

I forwarded an article “Common diabetes drug may work by changing gut bacteria, study finds”  to a reader and he responded:

  • “This is fascinating Ken, thank you. I belong to untold numbers of CFS and Lyme Facebook groups, newsletters, forums, etc. Many of them talk of Metformin as being the biggest and best “new thing” out there for treatment. Once again it seems that all roads lead to the microbiome…”

I am opposed to trying random “new things” but very much in favor of trying “new things” that the model that you are using would predict to help.  With the microbiome model, I have had a very good batting average 🙂 .

What do we know about Metformin?

Bottom Line

The known shifts for metformin appear to be beneficial for CFS/Lyme patients with no reported negative shifts. I suspect that it will likely improve some subset of symptoms (which ones are unknown). It would be nice to see a formal study done and published for CFS/FM/IBS.

It is reported to have some side effects:

Metformin can rarely cause a serious (sometimes fatal) condition called lactic acidosis. Stop taking metformin and get medical help right away if you develop any of the following symptoms of lactic acidosis: unusual tiredness, dizziness, severe drowsiness, chills, blue/cold skin, muscle pain, fast/difficult breathing, slow/irregular heartbeat, stomach pain with nausea, vomiting, or diarrhea.” — of course, lactic acidosis is suspected to be a significant part of CFS…

On Facebook, a reader wrote ” I took metformin xr for my diabetes and it ripped me up!! Killed me with my IBS, to the point that I had to stop taking it.