Beware nullifying probiotics by other “good stuff”

To illustrate the importance of being aware of interactions (which unfortunately can require retention levels above many CFS cognitive levels 😦 ) Consider the following:

A reader wrote this morning:

” The doctor has just prescribed mutaflor and ampicillin.”

We would love to believe that MDs, NDs, etc have complete understanding.

The Reality

I went to Mutaflor site and read:

“Antibiotic sensitivity of E. coli strain Nissle 1917

As a bacterial isolate from the pre-antibiotic era, E. coli strain Nissle 1917 (Mutaflor) is sensitive to all antibiotics  which are predominately directed against Gram-negative bacteria, e. g. coli bacteria.

A certain loss of ­Mutaflor-efficacy must be taken into account. Nevertheless, a protective ­Mutaflor-therapy should be initiated in addition to antibiotic therapy.

– Amikacin, [aminoglycoside]
— Amoxicillin/Clavulanic acid, [penicillin group of beta-lactam antibiotics]
— Ampicillin [penicillin group of beta-lactam antibiotics]
— Azlocillin [acylampicillin]
– Cefaclor [cephalosporin]
— Cefazolin [cephalosporin]
— Cefoperazone [cephalosporin]
— Cefotaxime [cephalosporin]
— Ceftriaxone [cephalosporin]
— Cephalotin [cephalosporin]
–Chloramphenicol [Amphenicol]
–Ciprofloxacin [quinolone]
– Doxycycline [tetracycline]
– Gentamicin [aminoglycoside]
– Latamoxef [penicillin beta-lactam]
– Mezlocilin [penicillin beta-lactam]
– Nitrofurantoin [macrolide]
— Norfloxacin [quinolone]
– Pipemidic acid [fluoroquinolones],
— Piperacillin [penicillin]
– Tetracycline [tetracycline],
— Ticarcillin [carboxypenicillin],
– Tobramycin [ aminoglycoside]
– Trimethoprim [Folic acid inhibitor]
– Sulfamethoxazole [sulfonamide]

Combination with antibiotics – natural antibiotic resistance of E. coli strain Nissle 1917

Mutaflor is not sensitive to antibiotics which are predominately directed against Gram-positive bacteria. That is why EcN may be combined with these ­antibiotics.

– Cefsulodin, Clindamycin [lincosamide]
– Erythromycin [macrolide]
– Metronidazole [Nitroimidazole]
– Penicillin G [Penicillin]
– Quinupristin/Dalfopristin [streptogramins]
– Rifampin [rifamycin]
– Teicoplanin [glycopeptide]
– Vancomycin [glycopeptide]”

Bottom Line

Trying to restore E.Coli has two probiotics available:  Mutaflor (covered above) and Symbioflor-2 . Both are known to take up residency and at least 1 is known to be human sourced. Studies found that Symbioflor-2 appears to have the same sensitivity [2008].

If antibiotics are taken, they should be done before E.Coli probiotics if one of the top list is prescribed. Antibiotics on the bottom list can be taken with E.Coli Probiotics. Personally, I suspect a cocktail of Metronidazole, Erythromycin and an E.Coli probiotic may play a similar role to CFS/IBS/SIBO etc as combination drug therapy does for H. Pylori infections.

Lactobacillus probiotics also kill off E.Coli!

The same issue exists with herbs and spices.  a rough way to get some guidance is to type the name of the herb/spice and “Gram-negative bacteria” (which E.Coli is)