This was an interesting post to draft.  Before I started doing uBiome analysis, the evidence suggested that Staphylococcus aureus was likely a key bacteria. “Maintainer Post -Jan 2016” and “A forgotten treatment post Jan 2016“.  The evidence suggests that it is not for most CFS patients. For a few it is (like one analysis that I am working on — which has the unexpected aspect of having high bifidobacterium).

I suspect that the success fighting Staphylococcus aureus above was because the items also reduced other bacteria genus.

For updated information see Microbiome Prescription

DataPunk.Net Data

INHIBITED BY

• Stevia
• Aloe vera
• Garlic (allicin)
• Cinnamon bark oil
• Peppermint oil
• Hyocyamine
• Berberine
• Thyme oil
• Resistant starch (type IV)
• Lemongrass oil
• Navy bean (Cooked)

ENHANCED BY

• Proton-pump inhibitors (PPI)

PubMed Data

There are 98700+ studies on PubMed for Staphylococcus aureus — this is only a sampling. Of material. It is very antibiotic resistant.

• Disease:
  • S. aureus can cause a range of illnesses, from minor skin infections, such as pimples,^[6]impetigo, boils, cellulitis, folliculitis, carbuncles, scalded skin syndrome, and abscesses, to life-threatening diseases such as pneumonia, meningitis, osteomyelitis, endocarditis, toxic shock syndrome, bacteremia, and sepsis Wikipedia
  • S. aureus produces various enzymes such as coagulase (bound and free coagulases) which clots plasma and coats the bacterial cell, Wikipedia
  • “the primary Sjogren’s syndrome subjects displayed an increased frequency of C.albicans, Staphylococcus aureus, enterics, and enterococci”[2001]
  • Dry Eye: “Eighty-eight strains were isolated (48 strains of Propionibacterium acnes, 26 coagulase-negative Staphylococcus [CNS] species, six Staphylococcus aureus strains, and eight others). Of the 26 CNS strains, 17 (65.4%) were fluoroquinolone resistant, including four (33.3%) of 12 methicillin-sensitive CNS and 13 (92.9%) of 14 methicillin-resistant CNS.” [2008]
  • Central nervous System: “Staphylococcus aureus plays an important role as a bacterial pathogen after traumatic injury. The majority of isolated strains produces alpha-toxin, a 33-kDa protein, with membrane-damaging and lethal effects. The central nervous system (CNS) has been considered as the possible target for the lethal action of this toxin.” [1991]
• Diet:
  • “fresh garlic, but not aged garlic, can kill certain bacteria such as E. coli, antibiotic-resistant Staphylococcus aureus, and Salmonella enteritidis in the laboratory.” [WebMd]
  • Anticariogenic activity of some tropical medicinal plants against Streptococcus mutans [2004] cites
    • G. glabra (licorice see this post),
    • K. pandurata(chinese ginger) and
    • P. angulata (gooseberry)
  • “Triphala a tradtional herbal Ayurvedic formula” [2017]
  • “Magnolol(magnolia bark) had significant effects on the activities of streptococcal Gtfs.” [2004]
  • Bacopa monnieri extract and its compound luteolin have a significant antimicrobial activity againstStaphylococcus aureus” [2015] on Swanson
  • Inhibition of the emergence of multi drug resistant Staphylococcus aureus by Withania somnifera root extracts[2011].
  • Black cumin Seed (Nigella sativa) reduces Staphylococcus aureus [2014]
  • Staphylococcus, Enterococcus, Enterobacter and Acinetobacter genera were susceptible to Cinnamon [2014]
  • combination of coconut oil, barberry and turmeric [2009]
  • Assessment of Bioautography and Spot Screening of TLC of Green Tea (Camellia) Plant Extracts as Antibacterial and Antioxidant Agents [2014]. “The maximum inhibition of Staphylococcus aureus was recorded by dimethyl sulphoxide extracts of green tea varieties.”
  • Essential oil of Curcuma longa inhibits Streptococcus mutans biofilm formation [2011]. aka Turmeric — note that it does not kill, just slows films.
  • “Water extract of Syzygium aromaticum [Clove] …Ficus carica[Figs] and Oleo europaea leaves [Olive Leaf] .. inhibited growth of Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes,” [2011]
  • Vitamin D deficiency in community-acquired [Streptococcus] pneumonia: low levels of 1,25(OH)2 D are associated with disease severity [2014].
  • “Our data demonstrate that S. officinalis, E. globulus, C. forskohlii, A. uva-ursi, C. chinensis, T. diffusa, A. californica, A. sativum, and L. tridentata all show promising direct antimicrobial activity against S. aureus.” [2014] The best ones were:
    • Salvia officinalis, Common Sage on Swanson
    • Eucalyptus globulus, Tasmanian bluegum – on Amazon on Swanson
    • Coleus forskohlii, Plectranthus barbatus, Indian Coleus — on Amazon on Swanson
    • Coptis chinensis, Chinese gold thread — on Amazon
    • Turnera diffusa, Damiana  — Swanson’s
    • Larrea tridentata, chaparral, gobemadora, greasewood, creosote bush — on Amazon on Swanson
• Probiotics:
  • “efficacy of Lactobacillus plantarum has been reported against Staphylococcus aureus.” [2017] [2016][2015] [2015].
  • Propionibacterium freudenreichii and Lactobacillus reuteri both impact Meticillin-resistant Staphylococcus aureus [2013] [2015] [2015]
  • In vitro and in vivo anti-microbial activity evaluation of inactivated cells of Lactobacillus salivarius CECT 5713 against Streptococcus mutans. [2017]
    • “prevents S. mutans adhesion to hydroxyapatite and could be used as a strategy to reduce the salivary concentration of this oral pathogen.”
  • ” L. paracasei-based toothpaste, PerioBiotic, is effective in the reduction of  Streptococcus mutans  monospecies biofilm, ” [2017]
  • ” L. casei Shirota, L. casei LC01, L. plantarum ST-III, L. paracasei LPC37 also significantly reduced the numbers of MS, Streptococcus spp., S. sanguinis and total bacteria in mixed biofilms compared with the control group (p<0.05). ” [2017]
  • Bacillus clausii, has been found to produce antimicrobial substances that are active against gram positive bacteria including but not limited to Staphylococcus aureus, Enterococcus faecium, and Clostridium difficile. [wikipedia]
  • “B. longum BB536 and L. rhamnosus HN001..a reduction of …  Streptococcus sinensis abundance” [2017]
• Antibiotics:
  • “A total of 2.4% (95CI%: 0.1-4.7%) of the [Streptococcus] pneumococcal strains were highly resistant to both phenoxymethylpenicillin and macrolides, whereas the highest resistance rates were to cefaclor (53.3%), followed by tetracycline (20%) and cefuroxime (12.1%).”[2017]
  • “penicillin – 5.41%, erythromycin – 8.1%, clindamycin – 4.05%, amoxicillin-6.76%, tetracycline 28.38%.” [2017]
  • “The rates of resistance and reduced sensitivity of the isolates for penicillin and ampicillin were determined at 61.2% and 55.1%, respectively. However, all isolates were found to be susceptible to vancomycin” [2016]
  • “a substantial group of strains is resistant to macrolides and the majority of strains are resistant to tetracycline.” [2016]
  • Assessment of the potential for resistance to antimicrobial violet-blue light in Staphylococcus aureus. [2017]
  • Phenotypic and genotypic characterization of antibiotic resistance of methicillin-resistant Staphylococcus aureus  isolated from hospital food. [2017]
    • “MRSA strains harbored the highest prevalence of resistance against penicillin (100%), ceftaroline (100%), tetracycline (100%), erythromycin (89.18%) and trimethoprim-sulfamethoxazole (83.78%). TetK (72.97%), ermA (72.97%), msrA (64.86%) and aacA-D (62.16%) were the most commonly detected antibiotic resistance genes.”

Bottom Line

We have a LOT of items cited above

Avoid

• Proton-pump inhibitors (PPI)
• Hospital Food

Take

• Vitamin D
• Licorice
• Triphala
• Figs
• Olive Leaf
• Turmeric
• Magnolia Bark
• Black cumin Seed
• Gooseberry
• Chinese Ginger, Fresh Ginger
• Stevia
• Aloe vera
• Garlic (allicin)
• Cinnamon bark oil
• Peppermint oil
• Hyocyamine
• Berberine
• Thyme oil
• Salvia officinalis, Common Sage
• Eucalyptus globulus, Tasmanian bluegum
• Coleus forskohlii, Plectranthus barbatus, Indian Coleus
• Coptis chinensis, Chinese gold thread
• Turnera diffusa, Damiana
• Larrea tridentata, chaparral, gobemadora, greasewood, creosote bush
• Withania somnifera 
• Green Tea
• Resistant starch (type IV)
• Lemongrass oil
• Navy bean (Cooked)
• Bacillus clausii
• Lactobacillus casei Shirota
• Lactobacillus casei
• Lactobacillus Reuteri
• Lactobacillus paracasei
• Lactobacillus plantarum
• Lactobacillus salivarius
• Propionibacterium freudenreichii