Blood Pressure and the Microbiome

Symptoms can be caused by microbiome shifts. Treatment for the symptoms are likely to also cause microbiome shifts. This is one of a planned series dealing with specific symptoms. I have already touched on Blood Pressure is some previous posts:

Literature

  • “several human studies showing that the human gut microbiome in patients with hypertension harbours lower microbial diversity and an increased Firmicutes:Bacteroidetes ratio accompanied by decreases in acetate-producing and butyrate-producing bacteria2,3. ” [Nature]
  • “These data indicate that non-obese and hypertensive rats harbor a different gut microbiota from obese rats and that exercise training alters gut microbiota from an obese and hypertensive genotype background.” [2014]
  • “Opportunistic pathogenic taxa, such as, Klebsiella spp., Streptococcus spp., and Parabacteroides merdae were frequently distributed in hypertensive gut microbiome,” [2017]
  • Restoration of A Healthy Intestinal Microbiota Normalizes Portal Hypertension In A Rat Model of Nonalcoholic Steatohepatitis. [2017]

High Blood Pressure

  • “In modern era, Ocimum sanctum Linn. (Tulsi) has been shown to be effective against diabetes mellitus, hypertension,” [2013]
  • “Several diseases have been linked to vitamin D deficiency, such as hypertension, diabetes, depression, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and chronic pain syndromes such as fibromyalgia. ” [2013]
  • “cardiovascular effects of probiotics Lactobacillus fermentum CECT5716 (LC40), or L. coryniformis CECT5711 (K8) plus L. gasseriCECT5714 (LC9) (1:1) …exert cardiovascular protective effects in genetic hypertension ” [2015]
  • “A meta-analysis of 9 randomized trials showed a significant decrease in both the systolic BP (SBP) and diastolic BP (DBP) in patients who consumed a daily dose of ≥1011 CFU of Lactobacillus helveticus (Khalesi et al., [2014]. “
  • Herbal Medicine for the Treatment of Cardiovascular Disease Clinical Considerations 1998
    • “The root of R serpentina (snakeroot), the natural source of the alkaloid reserpine, has been a Hindu Ayurvedic remedy since ancient times.
    • Stephania tetrandra is an herb sometimes used in traditional Chinese medicine to treat hypertension. “
    • “The root of Lingusticum wallichii is used in traditional Chinese medicine as a circulatory stimulant, hypotensive drug, and sedative.”
    • Uncaria rhynchophylla is sometimes used in traditional Chinese medicine to treat hypertension.”
    • Evodia rutaecarpa (wu-chu-yu) is a Chinese herbal drug that has been used as a treatment for hypertension.
  • ” Interventions such as oral antibiotic treatment2,5 and a high-fibre diet6 have been shown to attenuate high blood pressure and rebalance the dysbiotic gut microbiome in various hypertensive rodent models.” [Nature]
  • “We observed a significant increase in Gram-positive Streptococcus genus and Streptococcaceae family in the gut of the spontaneously hypertensive rat , both belonging to the order of Lactobacillales (lactic acid–producing bacteria) and the phylum of Firmicutes (Figure 6C, in red). This was consistent with changes we had previously observed in the Ang II–infusion hypertensive rodent model.22 Furthermore, we observed a significant decrease in the Bifidobacterium genus and the related Bifidobacteriaceae family of Actinobacteria phyla (Figure 6C, in green), a Gram-positive bacterium with probiotic properties.35,36 We also observed a decrease in several bacterial genera of the Bacteroidetes phyla.” [2017]
  • “All these genera were decreased in enterotype 1 as compared with enterotype 2 (Additional file 4: Figure S2b). Eight out of them were directly linked to Prevotella, while the other four, including OscillibacterFaecalibacteriumButyrivibrio, and Roseburia, were indirectly linked to Prevotella. These findings highlighted the possibility of Prevotella as a key genus associated with pre-hypertension (pHTN) and  hypertension(HTN). The difference in gut enterotype distribution revealed profound changes of the intestinal microbiome structure in both pHTN and HTN, implying the significance of gut microbes in the development of HTN.”2016
  • “The present meta-analysis suggests that consuming probiotics may improve BP by a modest degree, with a potentially greater effect when baseline BP is elevated, multiple species of probiotics are consumed, the duration of intervention is ≥8 weeks, or daily consumption dose is ≥1011 colony-forming units.” [2014] – 100 MCFU or 0.1 BCFU.
  • “Licorice root, whose active ingredient, glycerrhetinic acid (GA), inhibits renal 11β-HSD2, and thereby causes hypertension in some individuals. Bacterially derived glucocorticoid metabolites may cause hypertension in some patients by a similar mechanism. ” [2017]

Low Blood Pressure

  • “Black licorice induced hypertension is an uncommon cause of hypertension in modern times because newer types of licorice rarely use the active ingredients in licorice root in large quantities. ” [2015]
  • “Post-treatment with magnolol (Magnolia officinalis, Magnolia Bark) significantly attenuated the deleterious haemodynamic changes (e.g., hypotension and bradycardia) caused by lipopolysaccharide. ” [2010]

Bottom Line

Including information from Decreasing Prevotella genus

Avoid

  • Lactobacillus casei
  • Lactobacillus gasseri
  • Lactobacillus rhamnosus GG.
  • Lactobacillus salivarius
  • Rosemary

Take

  • Bifidobacterium bifidum strain Bb probiotics
  • Chicory
  • E.Coli probiotics
  • Grape seed extract (Resveratrol)
  • Inulin
  • Jerusalem artichoke
  • Lactobacillus Brevis
  • Lactobacillus Fermentum ME3 (Reg’Activ) has both documented impact on BP and the standard capsule contains > 1 BCFU.
  • Lactobacillus Reuteri
  • Lactobacillus Helveticus
  • Low carbohydrate diet
  • Resistant starch (type IV)
  • Streptococcus probiotics
  • Tulsi Tea
  • Vitamin D3 — typically 10,000-20,000 IU/Day is needed to get someone up to the top quarter for Vitamin D3, the area needed to see impact
  • Whole-grain barley