For updated information see Microbiome Prescription

Doctor’s Data tests will reports on C. Freundii and this is a summary of what can be done to reduce it. Citrobacter (genus) material is included.

DataPub.Net

Gammaproteobacteria -> Enterobacteriales -> Enterobacteriaceae -> Citrobacter -> Citrobacter freundii 

Nothing

PubMed etc

“our lab showed that exposure to the prolonged-restraint stressor prior to a challenge with C. rodentium alters the intestinal microbiota community structure, including a reduction of beneficial genera such as Lactobacillus, which may contribute to stressor-enhanced C. rodentium-induced infectious colitis”  [2013]

Disease

• “Urinary tract infections… abnormal inflammatory changes in the intestine, sometimes even resulting in necrotic changes….linked to neonatal meningitis” [edu]

Diet

• Dietary Chitosan Supplementation Increases Microbial Diversity and Attenuates the Severity of Citrobacter rodentium Infection in Mice[2016].
• “data indicated that the consumption of dietary fiber-rich diets ameliorates the effects of C. rodentium-induced enteritis ” [2016]
• “Dietary fiber deprivation, together with a fiber-deprived, mucus-eroding microbiota, promotes greater epithelial access and lethal colitis by the mucosal pathogen, Citrobacter rodentium.” [2016]
• “they find that a fiber-free diet promotes mucus-degrading bacteria and susceptibility to Citrobacter rodentium infection.” [2016]
• “Dietary vitamin D3 deficiency alters intestinal mucosal defense and increases susceptibility to Citrobacter rodentium-induced colitis. [2015]”
• “We also demonstrate the potential importance of vitamin B12 in controlling susceptibility to bacterial pathogens such as C. rodentium and S Typhimurium.” [2016]
• “After 5 weeks of dietary intervention, mice were challenged with Citrobacterrodentium, and pathological responses were assessed. Olive oil diets resulted in little colonic pathology associated with intestinal alkaline phosphatase…Fish oil combined with milk fat, unlike unsaturated lipid diets, had a protective effect ” [2016]
• White button mushrooms increase microbial diversity and accelerate the resolution of Citrobacterrodentium infection in mice [2013].
• Long-term selenium deficiency increases the pathogenicity of a Citrobacter rodentium infection in mice [2011].
• The pathogenicity of an enteric Citrobacter rodentium Infection is enhanced by deficiencies in the antioxidants selenium and vitamin E [2011].
• “A band corresponding to Citrobacter freundii (98% identity) was observed in almost all pigs from thymol groups, and only in 4 samples from pigs fed no thymol in the diet. ” [2008]

Prebiotic

• “Mice with pretreatment of L acidophilus, inulin, and both show reduced intestinal inflammation following Cr infection compared with controls” [2012]

Probiotic

• “Preadministration and coadministration of a probiotic mixture containing Lactobacillus helveticus and Lactobacillus rhamnosus  ameliorated C. rodentium” [2012]
• “While L. reuteri treatment did not reduce all aspects of stressor-enhanced infectious colitis, it did significantly reduce pathogen translocation from the colon to the spleen.”[2013]
• “. The results showed that administration of a combination of probiotics including Lactobacillus rhamnosus ATCC 53103, Lactobacillus acidophilus ATCC 4356 and Lactobacillus plantarum A significantly increased the production of CD11c⁺ dendritic cells in the spleen (3.62% vs phosphate buffered saline (PBS)-treated control, P<0.01) and mesenteric lymph nodes (MLNs)… for  a model of Citrobacter rodentium-induced colitis” [2016]

Antibiotics

• “usually treated with antibiotics like fluoroquinolones, carbapenems and cephalosporins. The treatment plan depends up on the vulnerability of the microbe to the antibiotics and the site of the infection. Conversely, there is a growing alarm over the levels of resistance of C. freundii to a number of antibiotics. Supportive treatment is given as well to hasten cure. ” [edu]
• Further details.

Bottom Line

Avoid

• Thymol

Take

• Fiber
• Fish Oil with Milk Fat
• Inulin
• Lactobacillus plantarum
• Lactobacillus rhamnosus
• Lactobacillus acidophilus
• Lactobacillus Reuteri
• Lactobacillus helveticus
• Selenium
• Vitamin E
• Vitamin D
• Vitamin B12
• White button mushrooms