The OCD CFS Suffer

A reader wrote and something triggered Obsessive-Compulsive Disorder (OCD) like behavior with him. He suspect stress (which is well known to alter the microbiome).  I remember that a physician in France had great success (80+% remission) of psychological issues using the rickettsia antibiotic protocol (i.e. Cecile Jadin) which alters gut bacteria — so let us review our current state of knowledge for OCD. For a general review of microbiome and mental illness see this paper.

PubMed Data

  • OCD is associated with “a history of complicated birth (OR = 5.54, P<.001), less family history of OCD (OR = 0.42, P = .014),”  [2011] – both of these are associated with microbiome inheritance and transference.
  • ” The results indicated that the induction of locomotor sensitization and compulsive checking was accompanied by changes in several communities of bacteria belonging to the order Clostridiales (class Clostridia, phylum Firmicutes), and predominantly in Lachnospiraceae and Ruminococcaceae families of bacteria. It is suggested that changes in these microbes may serve to support the energy use requirements of compulsive checking and obsessive-compulsive disorder.” [2017]
  • “Both stress and antibiotics are proposed as mechanisms by which gut microbiota are altered preceding the onset of OCD symptomology. In this light, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) leading to episodic OCD is explained not by group A beta-hemolytic streptococcal infections, but rather by prophylactic antibiotics that are administered as treatment. ” [2014]
  • Obsessivecompulsive-like behaviors in house mice are attenuated by a probiotic (Lactobacillus rhamnosus GG) [2014]

  • Serum Cytokine Profiles of Children with Obsessive-Compulsive Disorder Shows the Evidence of Autoimmunity. [2016]
    • “Interleukin-17A, tumor necrosis factor-α, and interleukin-2 levels were significantly higher in obsessive compulsive disorder patients,”

Bottom Line

Using DataPunk.Net we have:

Lachnospiraceae

INHIBITED BY

ENHANCED BY

 

Ruminococcaceae

INHIBITED BY

ENHANCED BY

 

And last,

  • Lactobacillus rhamnosus GG  (Culturelle® Probiotics)

Considering that Christmas is a few days away, load up on the sugar and fat for medicinal purposes 🙂  — see disclaimer below. Not responsible for weight gain.

This is an education post to facilitate discussing this approach with your medical professionals. It is not medical advice for the treatment of any disease. Always consult with your medical professional before doing any  changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.