Update of new Studies on my favorite probiotic

In 2014, I did my My favorite probiotic: E.Coli Nissle 1917 (Mutaflor) and today, I discovered there have been a lot more studies done on since this post. Is it still  my favorite?

Please note: I said FAVORITE (for me) and I am not claiming BEST.


Let us see what the new research says:

Bottom Line

Answer is YES — please try finding any other specific strain of any probiotic (except Lactobacillus rhamnosus GG which has been studied more) that has been as well studied with so many significant impacts!

Others appear to agree:

For an excellent history of Mutaflor /E. Coli Nissle 1917, see Insights from 100 Years of Research with Probiotic E. Coli. [2016] and Escherichia coli strain Nissle 1917-from bench to bedside and back: history of a special Escherichia coli strain with probiotic properties.[2016]

  • I’m in the US, so I am forced to use the Canadian Supplier, (thanks to the FDA — because it is effective, they treat it as an experimental drug and thus highly restricted)
  • It is available across Europe and also in Australia

Action Item for US Residents

The reason that it is not available in the US is the FDA and NOT the company. It was sold in the US for a while(2010-12) until the FDA forced it’s removal.


“Section 301(11) of the Federal Food, Drug, and Cosmetic Act (21 U.S.C. 331(11)) prohibits the introduction or delivery for introduction into interstate commerce of any food (including a dietary supplement) that contains a drug approved under 21 U.S.C. 355, a biological product licensed under 42 U.S.C. 262, or a drug or a biological product for which substantial clinical investigations have been instituted and their existence made public, ”

Write your congressman and senator, asking them to demand the FDA  to grant a waiver for Mutaflor to be sold in the US — just like it is in Australia, Canada and most of Europe. It has been in use for over 100 years. You may wish to copy and paste the PubMed articles above and in the prior post into your email or letter.

Background: https://me-pedia.org/wiki/Mutaflor