ME/CFS Relapse Report #7

Since the flare has gone on for 6 months, I have changed the title to relapse.

I should also mention that immediately after I took this sample, I altered supplements dramatically because ‘something felt like it was going in the wrong direction’. This lab results confirmed it when I look at Diversity by Taxonomy Rank, a 43% jump!

Diversity increased dramatically

Why is diversity important to monitor? Don’t you want high diversity? To me, the answer is no and appears to be backed up with this study on humans. “Increased Diversity due to increased abundance of less dominant taxa [as a result of stress]“[2017]. Since stress has always been the trigger, the increase of diversity should be a warning sign. More bacteria types means alterations of metabolites and chemical system — dysruption of a well operating microbiome. More is not better always.

A healthy gut ecosystem is rich in diverse species.[1][2] — I believe this is an over simplification

What Did I Change

I went over to my heavy duty kill evil bacteria supplements, namely significant dosages of:

  • Tulsi
  • Haritaki
  • Neem
  • Triphala
  • Wormwood
  • Olive Leaf
  • EDTA and NAC as biofilm breakers

Also because of a high blood pressure reading (predictable from microbiome) from an urgent care visit. I also added in (see this post for why):

  • Melatonin
  • Grape Seed Extract /Resveratrol
  • CoQ10
  • Fisetin
  • Lycopene
  • Pomegranate Extract
  • Piracetam
  • Nattokinease

The results were good:

  • Went from struggling to get to 6000 steps per day to over 10,000 steps on many days
  • Smart watch blood pressure readings dropped by at least 7mm

Ubiome Reports

Remember this reflects what was happening when I felt something was going the wrong direction and altered supplements etc. My gut feeling appear to have been very correct.

Propionate Collapsed
Polyamine Collapsed
Butyrate Collapsed
Lactobacillus and Akkermansia collapsed
Alcohol Reducing Bacteria also collapsed
More Collapse
And still more: Carbohydrates, Lipids and Amino Acid < 10%
Some good news – finally! Serotonin has improved

Vitamin K2 and B9 also reported as < 0.05 of selected samples.

Microbiome Prescription Site

First, it’s the charts of uBiome Predicted Metabolic Functions, scanning for interesting things – there are a lot…

For information about phagosome

A bunch of items to digest.

Condition Templates

Alzheimer’s Mimic

Back in 2012, I had a SPECT scan that was read as mild or early Alzheimer’s disease. I believed that this was caused by a microbiome shift. With the templates and samples, it appears to be confirmed. My microbiome has shifted to match that seen in Alzheimer’s. I am not explicitly concerned because I am working on restoring the microbiome.

High Blood Pressure

A recent urgent care had the physician concerned about my having high blood pressure. A little checking up found that some items that I was taking are known to include blood pressure (which I stopped), and then looked at my microbiome — as it appears that the root cause was the microbiome shift.

Changes in Suggestions

There was no striking difference in suggestions. That is not totally unexpected — the increase in biodiversity was likely in the minor or elusive bacteria. There is little literature on those. 😦

Ubiome reports 5 very elusive bacteria and 10 under 7.5% in the latest sample. The prior has ZERO elusive bacteria and only 2 under 7.5%. The one before has 1 elusive and 3 under 7.5 which was the patten back until 4-09-2019 (2nd and 3rd samples after relapse) when we also had 5 elusive and 10 under 7.5.

Bottom line: The goal is to suppress these elusive bacteria and reduce diversity. Looking over suggestions, I see that I may wish to also add:

  • Rhubarb
  • Oregano

One item that I became lazy about in the weeks before the last sample was having Barley Porridge every morning. It is high on the list and is the only change that I can identify. It was time consuming to prepared and I felt well enough that I thought that I could skip it — classic ME/CFS mistake.

The next analysis may be very interesting.