Neuroinflammation Bacteria

A reader asked me if we knew which bacteria causes neuroinflammation. This is what I could find documented (often in association with specific medical conditions that have neuroinflammation)

Nutrients 11 02714 g003 550

Undigested Food and Gut Microbiota May Cooperate in the Pathogenesis of Neuroinflammatory Diseases: A Matter of Barriers and a Proposal on the Origin of Organ Specificity. [2019]
  • ” increased in abundance in mice with PD microbiomes include Proteus sp., Bilophila sp., and Roseburia sp., with a concomitant loss of members of families Lachnospiraceae, Rikenellaceae, and Peptostreptococcaceae, as well as Butyricicoccus sp. (Figure 6E). Interestingly, some taxa are altered only in ASO (Different DNA) animals (e.g. Proteus sp., Bilophila sp., and Lachnospiraceae), while others display significant changes independent of mouse genotype (e.g. Rosburia sp., Rikenellaceae, and Enterococcus sp.) … depletions in members of family Lachnospiraceae and Ruminococceae in recipient mice, a notable finding as these same genera are significantly reduced in fecal samples directly from PD patients  ” [2017]
  • ”  the relative abundance of 89 taxa differed significantly between groups with the majority of these changes accounted for by the Clostridiales order and within that, Lachnospiraceae and Ruminococcaceae. These taxa showed a range of macronutrient specific correlations with place memory. In addition, Distance based Linear Models found relationships between memory, inflammation-related hippocampal genes and the gut microbiota. ” The effect of short-term exposure to energy-matched diets enriched in fat or sugar on memory, gut microbiota and markers of brain inflammation and plasticity. [2016]
  •  Finally, alteration of gut microbiota (i.e., an increase in Bacteroidetes phylum and in Prevotellaceae family at the end of the treatment and a decrease in Ruminococcaceae family, Oscillospira and Lachnospira genus at the end of the withdrawal period) was detected. In conclusion, finasteride treatment in male rats has long term effects on depressive-like behavior, hippocampal neurogenesis and neuroinflammation and gut microbiota composition. [2019]
  • the inflammation related family Erysipelotrichaceae was more abundant  [2018]

Bottom Line

Low levels of Ruminococcaceae and Lachnospiraceae is the most common feature.

These two are also associated with:

Misc Notes:

  • Sesame seed decreases [2019]