I’ve just added Fibromyalgia to the website’s Special Summaries. Both published studies and citizen science fail to find any strong patterns. Today (remember the site is constantly being updated with new studies), we see the following summary. Obtaining only two bacteria from citizen science seems to make a strong statement that while the microbiome may be a contributing factor, it is unlikely to be causal.
I tend to favor the root cause being tissue hypoxia with the tissue generating pain from a lack of oxygen.
- Abnormal microcirculation and temperature in skin above tender points in patients with fibromyalgia [2000]
- Tissue oxygen measurement and 31P magnetic resonance spectroscopy in patients with muscle tension and fibromyalgia [1997]
- [Microcirculatory changes over the tender points in fibromyalgia patients after acupuncture therapy (measured with laser-Doppler flowmetry)]. [2000]
- Microcirculation abnormalities in patients with fibromyalgia – measured by capillary microscopy and laser fluxmetry. [2004]
There may be multiple causes. One possible is coagulation products. Items like serrapetase, nattokinase and lumbrokinase may help. I could not locate any studies using these for FM.
Fibromyalgia
This list modifiers reported for specific conditions with links to studies.
Some of the items listed as improving may have inconsistent results from studies. It is recommended that the studies cited be review before considering any change.
| Modifier | Impact | Citations |
|---|---|---|
| bifidobacterium bifidum (probiotics) | Improves/Treats | 1 |
| CoQ 10 | Improves/Treats | 2 |
| d-ribose | Improves/Treats | 1 |
| Exercise | Improves/Treats | 1 |
| fish oil | Improves/Treats | 1 |
| green tea | Improves/Treats | 1 |
| lactobacillus acidophilus (probiotics) | Improves/Treats | 1 |
| lactobacillus casei (probiotics) | Improves/Treats | 1 |
| lactobacillus rhamnosus gg (probiotics) | Improves/Treats | 1 |
| L-carnitine | Improves/Treats | 1 |
| low-pressure hyperbaric oxygen | Improves/Treats | 1 |
| magnesium | Can cause/Worsen | 1 |
| magnesium | Improves/Treats | 7 |
| melatonin supplement | Improves/Treats | 1 |
| mirtazapine (prescription) | Improves/Treats | 3 |
| Pregabalin | Improves/Treats | 2 |
| SAM-e | Improves/Treats | 1 |
| Staphylococcus vaccine | Improves/Treats | 1 |
| trazodone hydrochloride (prescription) | Improves/Treats | 2 |
| Tryptophan | Improves/Treats | 2 |
| vitamin d | Improves/Treats | 4 |
Bacteria shifts from Pub Studies
Bacteria shifts from Citizen Science
This is based on the machine learning implemented on this site. Unpublished results.
| Observed | Bacteria Name | Rank | Relative Strength |
|---|---|---|---|
| High Levels | Bacteroides uniformis | species | 6 |
| High Levels | Lactobacillaceae | family | 2 |