I am reasonably complete in updating the database. If you know of any substances not shown below that have published peer review studies (a.k.a. PubMed) please email me with links so I may update it.
IBS is often concurrent with ME/CFS and FM.
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Irritable Bowel Syndrome
This list modifiers reported for specific conditions with links to studies.
Some of the items listed as improving may have inconsistent results from studies. It is recommended that the studies cited be review before considering any change.
| Modifier | Impact | Citations |
|---|---|---|
| aloe vera | Can cause/Worsen | 1 |
| aloe vera | Improves/Treats | 1 |
| bacillus coagulans (probiotics) | Improves/Treats | 8 |
| bifidobacterium (probiotics) | Improves/Treats | 1 |
| Boswellia serrata | Improves/Treats | 2 |
| clostridium butyricum (probiotics) | Improves/Treats | 4 |
| enterococcus faecium (probiotic) | Improves/Treats | 1 |
| Human milk oligosaccharides (prebiotic, Holigos) | Improves/Treats | 2 |
| hypericin(St. John’s Wort) | Can cause/Worsen | 1 |
| lactobacillus plantarum (probiotics) | Can cause/Worsen | 2 |
| lactobacillus plantarum (probiotics) | Improves/Treats | 2 |
| lactobacillus rhamnosus gg (probiotics) | Improves/Treats | 4 |
| l-glutamine | Improves/Treats | 1 |
| low fodmap diet | Improves/Treats | 13 |
| mutaflor escherichia coli nissle 1917 (probiotics) | Improves/Treats | 1 |
| peppermint (spice, oil) | Improves/Treats | 5 |
| Prescript Assist (Original Formula) | Improves/Treats | 2 |
| rifaximin antibiotics | Improves/Treats | 2 |
| Serum-derived bovine immunoglobulin/protein isolate | Improves/Treats | 4 |
| symbioflor 2 e.coli probiotics | Improves/Treats | 1 |
| vitamin d | Improves/Treats | 3 |
| vsl#3 (probiotics) | Improves/Treats | 5 |
Quantities from PubMed Studies on Irritable Bowel Syndrome
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| Direction | Substance | Notes | Source |
|---|---|---|---|
| Improves | vitamin d | supplemented weekly with 50,000 IU Vitamin D improve the severity of symptoms and QOL in patients with IBS | Source |
| Improves | vitamin d | oral vitamin D3 2000IU/day for 6 months can be effective in treating adolescents with IBS and vitamin D deficiency | Source |
| Improves | vitamin d | 50 000 IU vitamin D3 The IBSSS and the IBS-QoL scores in the vitamin D group significantly improved compared | Source |
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Bacteria shifts from Pub Studies
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Bacteria shifts from Citizen Science
This is based on the machine learning implemented on this site. Unpublished results.
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| Observed | Bacteria Name | Rank | Relative Strength |
|---|---|---|---|
| High Levels | Eubacteriaceae | family | 62 |
| High Levels | Eubacterium | genus | 48 |
| Low Levels | Akkermansia | genus | 105 |
| Low Levels | Bifidobacterium | genus | 100 |
| Low Levels | Pseudobutyrivibrio | genus | 77 |
| Low Levels | Subdoligranulum | genus | 76 |
| Low Levels | Lactobacillus | genus | 72 |
| Low Levels | Anaerotruncus | genus | 61 |
| Low Levels | Blautia | genus | 60 |
| Low Levels | Coriobacteriia | class | 58 |
| Low Levels | Roseburia | genus | 55 |
| Low Levels | Roseburia faecis | species | 55 |
| Low Levels | Acidaminococcales | order | 53 |
| Low Levels | Erysipelatoclostridium | genus | 52 |
| Low Levels | Bacteroides thetaiotaomicron | species | 51 |
| Low Levels | Faecalibacterium | genus | 51 |
| Low Levels | Peptostreptococcaceae | family | 45 |
| Low Levels | Verrucomicrobiaceae | family | 45 |
| Low Levels | Lachnospiraceae | family | 44 |
| Low Levels | Dorea formicigenerans | species | 44 |
Review
For citizen science looking at probiotics, we actually have a short list and a longer one from PubMed. Lactobacillus GG showed up on both, and on the actual studies list. Clostridium butyricum (probiotics) also has a match from PubMed bacteria to Actual Studies. Different oligosaccharides were on the take and avoid list. Unfortunately, most studies on IBS did not test differences (i.e. tested the forest and not the tree species).
On the avoid list was inulin and it’s associated jerusalem artichoke. Recommending that is a “pro-forma” suggestions from many physicians. So what gives? For that one I did find a study. The study results suggested that you should avoid it — a nice agreement.
However, flatulence severity was improved by prebiotics at doses ≤6 g/d (SMD: -0.35; 95% CI: -0.71, 0.00; P = 0.05) and by non-inulin-type fructan prebiotics (SMD: -0.34; 95% CI: -0.66, -0.01; P = 0.04), while inulin-type fructans worsened flatulence (SMD: 0.85; 95% CI: 0.23, 1.47; P = 0.007).
Prebiotics in irritable bowel syndrome and other functional bowel disorders in adults: a systematic review and meta-analysis of randomized controlled trials 2019
CFS Remission 