Drill down into Irritable Bowel Syndrome

I am reasonably complete in updating the database. If you know of any substances not shown below that have published peer review studies (a.k.a. PubMed) please email me with links so I may update it.

IBS is often concurrent with ME/CFS and FM.

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Irritable Bowel Syndrome

This list modifiers reported for specific conditions with links to studies.

Some of the items listed as improving may have inconsistent results from studies. It is recommended that the studies cited be review before considering any change.

ModifierImpactCitations
aloe veraCan cause/Worsen1
aloe veraImproves/Treats1
bacillus coagulans (probiotics)Improves/Treats8
bifidobacterium (probiotics)Improves/Treats1
Boswellia serrataImproves/Treats2
clostridium butyricum (probiotics)Improves/Treats4
enterococcus faecium (probiotic)Improves/Treats1
Human milk oligosaccharides (prebiotic, Holigos)Improves/Treats2
hypericin(St. John’s Wort)Can cause/Worsen1
lactobacillus plantarum (probiotics)Can cause/Worsen2
lactobacillus plantarum (probiotics)Improves/Treats2
lactobacillus rhamnosus gg (probiotics)Improves/Treats4
l-glutamineImproves/Treats1
low fodmap dietImproves/Treats13
mutaflor escherichia coli nissle 1917 (probiotics)Improves/Treats1
peppermint (spice, oil)Improves/Treats5
Prescript Assist (Original Formula)Improves/Treats2
rifaximin antibioticsImproves/Treats2
Serum-derived bovine immunoglobulin/protein isolateImproves/Treats4
symbioflor 2 e.coli probioticsImproves/Treats1
vitamin dImproves/Treats3
vsl#3 (probiotics)Improves/Treats5

Quantities from PubMed Studies on Irritable Bowel Syndrome

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DirectionSubstanceNotesSource
Improvesvitamin dsupplemented weekly with 50,000 IU Vitamin D improve the severity of symptoms and QOL in patients with IBSSource
Improvesvitamin doral vitamin D3 2000IU/day for 6 months can be effective in treating adolescents with IBS and vitamin D deficiencySource
Improvesvitamin d50 000 IU vitamin D3 The IBSSS and the IBS-QoL scores in the vitamin D group significantly improved comparedSource

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Bacteria shifts from Pub Studies

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ObservedBacteria NameRankDocumentation
High LevelsActinobacteriaphylumCitation
High LevelsAkkermansia muciniphilaspeciesCitation
High LevelsBacillus aeruginosusspeciesCitation
High LevelsBacteroidaceaefamilyCitation
High LevelsBacteroidesgenusCitation
High LevelsBacteroidesgenusCitation
High LevelsBacteroides thetaiotaomicronspeciesCitation
High LevelsChristensenellaceaefamilyCitation
High LevelsClostridiaclassCitation
High LevelsClostridialesorderCitation
High LevelsDesulfovibriogenusCitation
High LevelsDesulfovibrionaceaefamilyCitation
High LevelsDialister invisusspeciesCitation
High LevelsEnterobactergenusCitation
High LevelsEnterobacteriaceaefamilyCitation
High LevelsEnterobacteriaceaefamilyCitation
High LevelsEnterococcusgenusCitation
High LevelsErysipelotrichaceaefamilyCitation
High LevelsEscherichia colispeciesCitation
High LevelsEscherichia colispeciesCitation
High LevelsFaecalitaleagenusCitation
High LevelsLachnospiraceaefamilyCitation
High LevelsMethanobrevibacter smithiispeciesCitation
High LevelsMycoplasma hominisspeciesCitation
High LevelsOscillospiraceaefamilyCitation
High LevelsPrevotellagenusCitation
High LevelsPrevotellagenusCitation
High LevelsPrevotellagenusCitation
High LevelsPrevotellagenusCitation
High LevelsPrevotellagenusCitation

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Bacteria shifts from Citizen Science

This is based on the machine learning implemented on this site. Unpublished results.

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ObservedBacteria NameRankRelative Strength
High LevelsEubacteriaceaefamily62
High LevelsEubacteriumgenus48
Low LevelsAkkermansiagenus105
Low LevelsBifidobacteriumgenus100
Low LevelsPseudobutyrivibriogenus77
Low LevelsSubdoligranulumgenus76
Low LevelsLactobacillusgenus72
Low LevelsAnaerotruncusgenus61
Low LevelsBlautiagenus60
Low LevelsCoriobacteriiaclass58
Low LevelsRoseburiagenus55
Low LevelsRoseburia faecisspecies55
Low LevelsAcidaminococcalesorder53
Low LevelsErysipelatoclostridiumgenus52
Low LevelsBacteroides thetaiotaomicronspecies51
Low LevelsFaecalibacteriumgenus51
Low LevelsPeptostreptococcaceaefamily45
Low LevelsVerrucomicrobiaceaefamily45
Low LevelsLachnospiraceaefamily44
Low LevelsDorea formicigeneransspecies44

Review

For citizen science looking at probiotics, we actually have a short list and a longer one from PubMed. Lactobacillus GG showed up on both, and on the actual studies list. Clostridium butyricum (probiotics) also has a match from PubMed bacteria to Actual Studies. Different oligosaccharides were on the take and avoid list. Unfortunately, most studies on IBS did not test differences (i.e. tested the forest and not the tree species).

From Citizen Science
From PubMed

On the avoid list was inulin and it’s associated jerusalem artichoke. Recommending that is a “pro-forma” suggestions from many physicians. So what gives? For that one I did find a study. The study results suggested that you should avoid it — a nice agreement.

 However, flatulence severity was improved by prebiotics at doses ≤6 g/d (SMD: -0.35; 95% CI: -0.71, 0.00; P = 0.05) and by non-inulin-type fructan prebiotics (SMD: -0.34; 95% CI: -0.66, -0.01; P = 0.04), while inulin-type fructans worsened flatulence (SMD: 0.85; 95% CI: 0.23, 1.47; P = 0.007).

Prebiotics in irritable bowel syndrome and other functional bowel disorders in adults: a systematic review and meta-analysis of randomized controlled trials 2019