For readers that have contributed their uBiomes, we have added more profiles from studies with one important enhancement.  A sample of common symptoms are also shown with check boxes above the analysis. When you look at the results, please contribute your symptoms for those listed. There is a link to the full list, but with cognitive fatigue — that list can be too much for many people.

Remember — adding your symptoms increases the value of your uploaded ubiome for research.

Example: Gout

What’s there?

As new studies are published, their information will be added and new ones added, for example for SIBO.

• ADHD – Attention-deficit syndrome
• Alzheimer’s Disease
• Autism
• Autoimmune Disease
• Chronic Fatigue Syndrome
• Diabetes Type 2
• Crohn’s Disease
• Depression
• Fibromyalgia
• Gout (Arthritis)
• High Blood Pressure
• Histamine Issues
• Inflammatory Bowel Disease
• Irritable Bowel Syndrome
• Metabolic Syndrome
• Mood Disorders
• Rheumatoid arthritis
• Schizophrenia
• Ulcerative colitis

A reader messaged me because a member of their family has just gotten a diagnosis of arthrosis. They asked if it could be caused by the microbiome? Arthritis  affect your bones, ligaments, and joints. Often this means joint stiffness and pain.

Arthritis is an umbrella term describing several conditions. It includes:

• osteoarthritis (OA) also known as arthrosis
• rheumatoid arthritis (RA), and
• gout.

There are many conditions that distinctive microbiome profiles have been discovered. If you have a uBiome done, I have created pages to compare the ubiome against the published profiles. One of these is rheumatoid arthritis, as shown below (you must have uploaded ubiome to see the results)

The studies used for this page included:

• Alteration of Fecal Microbiota Profiles in Juvenile Idiopathic Arthritis. Associations with HLA-B27 Allele and Disease Status.
• The Microbiome: a Revolution in Treatment for Rheumatic Diseases?
• Role of the Gut Microbiome in Modulating Arthritis Progression in Mice.
• An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis
• [THE USE OF PROBIOTICS IN PATIENTS WITH RHEUMATOID ARTHRITIS].
• The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment.

A quick search on PubMed found significant research in this direction for osteoarthritis.

• The Microbiome and Bone and Joint Disease. 2017
  • “Although animal studies implicate the microbiome in the development of bone and joint disease, available results are limited and can be conflicting.”
• Akkermansia muciniphila May Determine Chondroitin Sulfate Ameliorating or Aggravating Osteoarthritis. 2017
  • So the microbiome determines the effectiveness of a treatment!
• Metabolic syndrome-associated osteoarthritis. (2017)
  • Metabolic syndrome has a known profile which is on the analysis site.
• Diet-Intestinal Microbiota Axis in Osteoarthritis: A Possible Role. 2016
• Relationship between inflammation, the gut microbiota, and metabolic osteoarthritisdevelopment: studies in a rat model. 2015

I was unable to find studies reporting a specific microbiome profile for osteoarthritis.

For Gout, we find:

• Combined Signature of the Fecal Microbiome and Metabolome in Patients with Gout.
  • “The signatures of microbiome showed being up-regulation of opportunistic pathogens, such as Bacteroides, Porphyromonadaceae Rhodococcus, Erysipelatoclostridium and Anaerolineaceae”
  • “The LefSe method revealed that the phylum Bacteroidetes and its derivative (Bacteroidia, Bacteroidales, Bacteroidaceae as well as Bacteroidales S24_7 group and Porphyromonadaceae), the phylum Chloroflexi and its derivatives (Anaerolineae, Anaerolineales, and Anaerolineaceae), the order Corynebacteriales and its derivative (Nocardiaceae and Rhodococcus), the class Erysipelotrichia and its derivatives (Erysipelotrichales, Erysipelotrichaceae and Erysipelatoclostridium), and the class Negativicutes and its derivative (Selenomonadales) were all higher in the intestinal microbiota from the gout patients. Conversely, the family Vibrionaceae and its derivatives (Photobacterium and Vibrio), the genus Coprococcus 3, Lachnospiraceae NC2004 group, Lachnospiraceae UCG_005, Ruminococcaceae NK4A214 group and Ruminococcaceae UCG_011 were all lower in the intestinal microbiota from the gout patients.”
  • Additionally the metabolites (KEGG) found significant differences.
    

Bottom Line

All of the different types of Arthritis appear to have distinctive profiles according to published studies. There are also metabolite shifts (since these are produced by bacteria — this is expected). Metabolites are the supplies for the body.

One item was very significant — two people may have similar metabolites shifts, and thus the same diagnosis — BUT have different bacteria causing this shift.  If the person has high or low Akkermansia muciniphila,will determine if they have a positive or negative response to Chondroitin Sulfate. This later reality is what I have started to suspect for all of the microbiome caused conditions:

• The symptoms are caused by the metabolite shifts.
  • There may be many combinations of bacteria shifts that can cause a similar  metabolite shift.

This is an education post to facilitate discussing this approach with your medical professionals. It is not medical advice for the treatment of any medical condition. Always consult with your medical professional before doing any  changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.

This post looks at three more people that have done 2 microbiome results over time.

Example 1

Following recommendations

 Example 2

This was a series of ubiome done around 2016. A health professional attempted to deal with the microbiome dysfunctions with traditional conventional processes.

Example 3

Treatment is unknown, but by the ubiome numbers, would have occurred after recommendations became available OR have been a natural / spontaneous improvement.

Bottom Line

There is growing evidence that the recommendations appear to:

• Normalize metabolite functions (KEGG)
• Reduce the typical microbiome signature across multiple autoimmune like conditions.

Our base assumption is that symptoms are caused by the shifts. There is no objective way to measure symptoms (and with memory issues often being involved, it makes it a more unreliable evaluation method). We can measure the two above items, and do observe improvements.

This is an education post to facilitate discussing this approach with your medical professionals. It is not medical advice for the treatment of any medical condition. Always consult with your medical professional before doing any  changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.

There was been a bunch of changes over the last week (and this weekend).

• ubiome kit 15% discount code:  BIOTICS15
• On Apples, the Buttons do not show up well, so I have modified their presentations
• Caught and fixed a few bugs in the Alternative Labs.
  • I tested each by setting Lactobacillus low only and compared recommendations. If you have the cycles, please re-test and report any issues.
• Remember login information as cookies — this will making log on easier. Just return to the page and the information will be automatically filled in.
  

Statistics on what data we use is now shown

We have 1600+ known items that will modify the gut, and some 76000+ relationships on how it will be modified. A lot of the items added this week were from drugs. Work is starting on expanding non-drugs data.

If you are on a prescription drug, you may find it (and it’s impact) on the updated modifiers.

http://microbiomeprescription.com/library/summary

Data Summary

Bacteria family112

Improved Navigation

From the sample selection pages, we have made links to other pages clearer:

Similarly for condition profiles

Bottom Line

I hope this makes navigation easier.  I have started working with data scientists at the Allen Institute to improve the data we are using. My focus for the next few weeks will be to increase our knowledge of non-prescription ways of modifying the microbiome.

Needless to say, adding symptoms and copying the KEGG/metabolism data across to the site will both:

• allow research to happen better
• allow you to see objective progress over time (i.e. KEGG/ metabolism improved, autoimmune profiles improve).

This is an education post to facilitate discussing this approach with your medical professionals. It is not medical advice for the treatment of any medical condition. Always consult with your medical professional before doing any  changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.

DayTwo (https://www.daytwo.com/ ) provides a microbiome test and nutritional recommendations ($349 covering some 92 taxonomy units verus $80 for hundreds with uBiome.com). Their focus appears to be:

“DayTwo analyzes your microbiome to predict blood sugar responses to thousands of different foods. High blood sugar is linked to energy dips, excessive hunger, weight gain and increased risk of obesity and diabetes”

A reader forwarded me their report  and I have implemented a suggestions page for it at:

• http://microbiomeprescription.com/Kyber/DayTwo

Selling nutritional suggestions off microbiome is a “hot area” for marketing. My concern is that the advice for more belief based recommendations instead of science based recommendations.

They score foods with A,B,C grades as shown below

For the reader, an example of food recommendations from their report:

MicrobiomePrescript Recommendations

This is a healthy active individual but with some significant shifts in some of the measures.

The rice and pasta suggestions above matches with the avoid a no carbohydrate diet above.

Bottom Line

This company appear to attempt a menu service based on their microbiome results which seems to be targeted at healthy people