I have also created a list of common probiotics that contain lactic acid producers. The list is here. These are probiotics that should be avoided.
NOTE: This is just one viable model. Another model is too few lactic acid consumers. Another model is acute and chronic hepatic insufficiency [1977]. If you have uploaded your microbiome, you can see your relative ranking for production (with a crude estimate for the amount)
In addition to the above, the microbiome prescription site site has a option to explicitly reduce the lactic acid producers in your microbiome.
A video of what I describe below
When you go to Advance Suggestions and click see Bacteria Selection Choices
You will find at the bottom of the page, a new section: the Lactic acid/Lactate producing bacteria reported in your sample where you have more than the median amount.
Note that I have no Lactobacillus or Bifidobacterium in this list.
Back on the custom suggestion pages, I select this filter option, as shown below.
Then filter the modifiers and click for suggestions:
Bottom Line
This is all theoretical and focuses solely on reducing bacteria associated with lactic acid and lactate production. The suggestions should be reviewed by a medical professional before starting. It may potentially make other issues worst, so use caution and make sure you are being monitored.
A reader email indicating that he believe that some of my suggestions also produced lactic acid. At present that is no option for filtering, but I am working on that. This appears to be a subset of ME/CFS patients. A 2015 Guest Blog post on Health Rising provided a summary of early studies. The latest study is below.
This is associated with neurlogical issues (brain fog etc).
Sleep Consequences
Sleep issues in ME/CFS may be connected to excessive D-Lactic acid (A known characteristic of ME/CFS)
Results and conclusion: Administration of L-lactate does not influence sleep-wake cycle of experimental animals. At the same time, its artificial optical analog D-lactate induces the significant (as compared to the control) decrease in wake (34.8% to 26.5%) and increase in slow wave sleep (57.4% to 69.2%). It has been suggested that D-lactate may be the antagonist of one or several L-lactate receptors.
See this post: on what this bacteria does with lactic acid.
I have lactate acid producer estimates on the microbiomeprescription site for uploaded 16s samples (typically ubiome). My own numbers appear to follow the research. With onset it kept increasing, and with the last ubiome started to decrease.
I did not have significant neurological issues BUT these values are all low according to the uploaded samples. Which suggests that while the amount increased, it did not reach impairing levels for neurological issues
The list below are what is in the database as producing the two items above. If you know of additional items, please forward the information (with a link to the study of course!).
A reader expressed frustration because he could not remember his symptoms when he took his ubiome sample. In response to this, I have added a new page to allow you to record symptoms when you do a sample AND these symptoms will be automatically applied to your next upload.
If you log on first, the email should be yours. If you have never done an upload, then enter your email, click Look Up (to clear out any symptom that some one added to the bogus email) and proceed.
You can return later and adjust the symptoms if you wish.
This item has been on my backburner for a while and today I came up with an efficient algorithm to compute a short most probable symptoms. The results on my own samples were actually quite accurate.
The process is simple: Apply analysis (AI techniques) to the uploaded microbiome samples annotated with symptoms. We then flip the results to predict from an individual sample using these results. A lot of computational magic going in and out.
I have MTHFR issues (reported by conventional testing), this is my age range, cold hands and feet, I have been well aware since the 1970’s of eye focus issues (from eye specialist). The disorientation matches up with my being a high functioning autism spectrum person. The last item makes it a slam dunk….
I checked another person who I know the medical history. The person has TMJ, and just about every symptom listed!
Where is this new feature
One thing that I realized that it predicted symptoms that I would NOT associate with my current state– but actually matches the long term medical issues. For example, eye focus issues — that goes back 40 years and which is not on my radar as an active symptom.
I suspect “mouth sores” which showed up on other issues — may include gum disease being active.
Addendum
A reader try it and posted on facebook.
As a result, I added a link to the page to also give extended prediction with an indicator of the prediction confidence (score).
For new readers: I have had Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) three times in my life and recovered each time. As a result of work stress, I am currently in a ‘flare’, because it was sudden onset and I realized what it was on day one and took aggressive action it did not become established. Established usually means six months of tests ruling out all of the possible alternative causes for the symptoms!
The model foe ME/CFS that I use is a microbiome dysfunction. I reached this conclusion long before mainstream research started to investigate and confirm that it does appear to be that, Some recent literature:
Instead of the usual 6 months of testing for what is not there, I proceeded to get my ubiome done. I had two earlier ones done from when I was in remission. I have an actual base line to compare to. This makes interpreting data a lot simpler. It also mean that I could quickly confirm ‘my gut feeling’ that is was ME flaring.
Following suggestions from my last microbiome results
I had an interesting experience with a morning bowel of barley (β-Glucan) with unpasteurized yogurt with beet sugar. The first two days, felt good, day 3 & 4 sore throat appeared. Missed a day and sore throat disappear. Back on barley and day 2, sore throat re-appear, more mild than before. Disappeared a couple of days later.
I am assuming that the barley and beet sugar feeds bacteria that are attacking other bacteria significantly. The wife was surprised when she tasted the beet sugar — it was not as sweet as cane sugar. I must admit to be confused by the sugar industry saying they are identical, and do find some support for them being different, like in this article.
Oats or barley for β-glucan
This study compares in the same experiment the β-glucan content of nine barley and 10 oat genotypes grown at two locations in each of two years (i.e., four environments) in North Dakota. Averaged across genotypes, total β-glucan content of barley and oat groat was similar.
Longer periods of mild physical activity before warning signs of two much activity (hiccups — a family trait that my kids always have when they are over tired. Sweats (even on a cold morning with no jacket), lisp in speech appears. By longer, I mean has increased from about 11 minutes until just under 20 minutes.
I can handle a 20 minute drive fine and keep to that distance bound. When I have gone longer, suddenly a ton of bricks hits, no gradual tiring.
Longer periods of sleep at night and more sleep. In the past it was short periods only (90-120 minute) then I was awake for a while. Now, I may get up to 6 hrs in a stretch.
Much more refreshed at waking in the morning.
Weight loss — some 20 lbs. Little appetite.
Still experiencing some Multiple Chemical Sensitivity issues, minor — but my work location is toxic with them, so it’s working remotely or leave as the only viable options.
UBiome Results
In my last post I gave the history of my readings for Lactobacillus, Bifidobacterium and Akkermansia. There was a little improvement in two of them,. but they are still magnitudes below my past normals.
Other Good News
Serotonin has returned to normal range, but GABA is at around 4% of most people
Old News – Ubiome Edition
Still flat lining theseGraphic of my last postAnti Inflammatory Polyamine is flat lining still Anti Inflammatory Propionate is flat lining still Anti Inflammatory butyrate is flat lining still At the phylum level the “new kids” are going down, but Actinobacteria is still very elevated. Dropping down to the Genus Level we see we see some of the specific disturbances
On the image below, the 2018 values are from remission, 2019 are during the flare.
Dropping down to the Genus Level we see we see some of the specific disturbances Growth is reversing itselfFirst value is Healthy valuesAlistipes drop by a factor of 3 and is now recoveringAbove are the elusive bacteria reported by uBiome
In terms of the rare/elusive bacteria, we see many of them disappear as the flare progresses, and strangers appear. The strangers are disappearing and some old friends, like Caldicoprobacter are returning. The high Bacillus count was likely from taking Bacillus coagulans as a probiotic.
In terms of predicted function using KEGG Pathway database, we can see the dynamic shifts. Two OVER represented at the start, has collapsed with a little sign of recovering.
Old News – MicrobiomePrescription Edition
In terms of symptoms associated with bacteria, there was a significant drop in the number of Condition Matches. We must be careful not to read too much into that, because a microbiome in the process of changing (which we see above) will not match the patterns of people who are stable.
Bottom Line
The direction is improving. The improvement can be seen in both the microbiome and the symptoms moving closer to my pre-flare state. Recovery is fragile and in one sense, I am likely in the most dangerous time — significant symptom improvement and one could stop being diligent in keeping to a treatment plan. Over the decades, I have seen too many people make a good solid recovery and then crash because they pushed themselves too far in recovery.
My criteria is simple and objective: Microbiome must return to the older state, especially the levels of lactobacillus and bifidobacteria; but also for other genus that either waxed or waned during the flare. Being disciplined and objective is essential.
I am still “living in a plastic bubble” of restrictions. The bubble is slowly expanding.
CFS Remission 