For updated information see Microbiome Prescription

DataPub.Net

Firmicutes -> Negativicutes -> Selenomonadales -> Veillonellaceae -> Mitsuokella

ANTIBIOTIC RESISTANCE

• Tetracycline 

PubMed etc

There are 50+ studies on PubMed

Disease

• “Megasphaera, Mitsuokella, and Sutterella were higher in Environmental enteric dysfunction (EED) and Succinivibrio, Klebsiella, and Clostridium_XI were lower in EED.” [2017]
• Mitsuokella dentalis in human periodontitis.[1994]

Diet

• “The bacterial gene library analysis indicated that Mitsuokella and Megasphaera were more frequently detected, while Clostridium disporicum were detected less frequently in the whey period.” [2011]
• “Dialister, Acidaminococcus, Bifidobacterium, Megasphaera and Mitsuokella were greater (P< 0·05) in moderate-protein, moderate-carbohydrate-fed kittens than High-protein, low-carbohydrate ” [2012]

Prebiotic

• “The increases that occurred in Firmicutes (p=0.026), Lactobacillus (p=0.045) and Mitsuokella(p=0.012) were significantly greater in the high fermentable carbohydrate gut models (inulin-type fructan prebiotic). ” [2017]

Probiotic

• “Reutericyclin producing L. reuteri increased the abundance of Dialister spp. and Mitsuokella spp. (P < 0.05) ” [2015]

Antibiotics

Bottom Line

Avoid

• Lactobacillus Reuteri
• Inulin

Take

• High-protein, low-carbohydrate diet

List of common CFS Symptoms — What’s missing?

I am working on a website to automate uBiome analysis. Part of the process is to record symptoms at the time that the ubiome sample was taken. The purpose of this information is to try to identify certain symptoms with certain shifts in the microbiome.

I am working off the Canadian Definition with links to http://me-pedia.org/ for explanations. The list is below.

Bottom Line

Please go thru the above and identify if all of your symptoms are there. If not what is missing.  Thanks!

Autonomic Manifestations

     nausea (More Information)
     bladder dysfunction (More Information)
     cardiac arrhythmias (More Information)
     Cortisol disorders or irregularity
     delayed postural hypotension (More Information)
     exertional dyspnea (More Information)
     extreme pallor (More Information)
     irritable bowel syndrome (More Information)
     light-headedness (More Information)
     Neurally mediated hypotension (NMH) (More Information)
     Orthostatic intolerance (More Information)
     palpitations (More Information)
     Postural orthostatic tachycardia syndrome (POTS) (More Information)
     urinary frequency dysfunction (More Information)

Comorbid

     Cancer
     Cushing Syndrome
     Electromagnetic Sensitivity (EMF)
     Fibromyalgia (More Information)
     Hypothyroidism (More Information)
     IBS (More Information)
     Mold Sensitivity / Exposure
     Multiple Chemical Sensitivity

Comorbid-Mouth

     Bruxism – Jaw cleanching / Teeth grinding
     Dry Mouth
     Gingivits / Gum Disease
     Periradicular periodontitis inflammatory / chronic lesion around roots of teeth
     TMJ / Dysfunction of the temporomandibular joint syndrome

General

     Fatigue (More Information)
     Headaches (More Information)
     Myalgia (pain) (More Information)

Immune Manifestations

     Alcohol Intolerant
     chemical sensitivities. (More Information)
     general malaise (More Information)
     medication sensitivities.
     new food sensitivities (More Information)
     Abdominal Pain
     Bloating
     Constipation
     Diarrhea
     Genitorinary / Nocturia – Urinary issues
     Hair loss
     High Altitude Intolerance
     recurrent flu-like symptoms (More Information)
     recurrent sore throat (More Information)
     tender lymph nodes (More Information)
     Thick blood / Hypercoagulation

Infection

     Epstein-Barr virus (More Information)
     Human Herpesvirus 6 (HHV6) (More Information)
     Lyme (More Information)
     Mycoplasma (More Information)
     Parasite – Other
     Parasites – Giardia (More Information)
     Parvovirus (More Information)
     Q Fever (Coxiella burnetii) (More Information)
     Varicella Zoster Virus

Neuroendocrine Manifestations

     abnormal appetite (More Information)
     cold extremities (More Information)
     intolerance of extremes of heat and cold (More Information)
     marked diurnal fluctuation (More Information)
     marked weight change (More Information)
     subnormal body temperature (More Information)
     sweating episodes (More Information)
     Air Hunger
     anorexia (More Information)
     Dry Eye
     Excessive adrenaline
     Laboured breathing
     loss of adaptability (More Information)
     Muscle weakness
     Neuralgia (More Information)
     Paraesthesia (tingling burning of skin) (More Information)
     recurrent feelings of feverishness (More Information)
     worsening of symptoms with stress. (More Information)

Neurological – Vision

     Blurred Vision
     inability to focus eye/vision (More Information)

Neurological

     Impairment of concentration (More Information)
     Spatial instability and disorientation (More Information)
     Ataxia (lack of volunatary muscle control)
     Cognitive Overload
     Confusion (More Information)
     Difficulty processing information (Understanding) (More Information)
     Difficulty reading
     Disorientation (More Information)
     Dysautonomia (More Information)
     emotional overload (More Information)
     Excutive Decision Making (Difficulty making)
     fasciculations (More Information)
     High degree of Empathy before onset
     Joint hypermobility
     Myoclonic jerks or seizures
     Neuropathy (More Information)
     Seasonal Affective Disorder (SAD) (More Information)
     Short-term memory issues (More Information)
     Slowed speech
     Slowed thought (More Information)
     Word-finding problems (More Information)

Neurological-Audio

     hypersensitivity to noise (More Information)
     Tinnitus (ringing in ear) (More Information)

Neurological-Sleep

     Chaotic diurnal sleep rhythms (Irratic Sleep) (More Information)
     Inability for deep (delta) sleep
     Insomnia
     Night Sweats
     Prolonged Sleep
     Sleep Apnea (More Information)
     Sleep Reversal
     Unrefreshed sleep (More Information)
     Vivid Dreams/Nightmares

Neurological-Vision

     Acquired or exertional dyslexia
     Impaired Depth Perceptions
     photophobia (Light Sensitibity) (More Information)

Onset

     Gradual
     less than 02 years since onset
     less than 04 years since onset
     less than 08 years since onset
     less than 16 years since onset
     less than 32 years since onset
     over 31 years since onset
     Sudden

Post-exertional malaise

     inappropriate loss of physical and mental stamina, (More Information)
     General (More Information)
     Rapid cognitive fatigability, (More Information)
     Rapid muscular fatigability, (More Information)

Intent

The data collected will be available without any personal information (i.e. email, age, gender, etc) as an “R” data set for people interested in doing research.

A reader wrote and something triggered Obsessive-Compulsive Disorder (OCD) like behavior with him. He suspect stress (which is well known to alter the microbiome).  I remember that a physician in France had great success (80+% remission) of psychological issues using the rickettsia antibiotic protocol (i.e. Cecile Jadin) which alters gut bacteria — so let us review our current state of knowledge for OCD. For a general review of microbiome and mental illness see this paper.

PubMed Data

• OCD is associated with “a history of complicated birth (OR = 5.54, P<.001), less family history of OCD (OR = 0.42, P = .014),”  [2011] – both of these are associated with microbiome inheritance and transference.
• ” The results indicated that the induction of locomotor sensitization and compulsive checking was accompanied by changes in several communities of bacteria belonging to the order Clostridiales (class Clostridia, phylum Firmicutes), and predominantly in Lachnospiraceae and Ruminococcaceae families of bacteria. It is suggested that changes in these microbes may serve to support the energy use requirements of compulsive checking and obsessive-compulsive disorder.” [2017]
• “Both stress and antibiotics are proposed as mechanisms by which gut microbiota are altered preceding the onset of OCD symptomology. In this light, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) leading to episodic OCD is explained not by group A beta-hemolytic streptococcal infections, but rather by prophylactic antibiotics that are administered as treatment. ” [2014]

• Obsessive–compulsive-like behaviors in house mice are attenuated by a probiotic (Lactobacillus rhamnosus GG) [2014]

• Serum Cytokine Profiles of Children with Obsessive-Compulsive Disorder Shows the Evidence of Autoimmunity. [2016]
  • “Interleukin-17A, tumor necrosis factor-α, and interleukin-2 levels were significantly higher in obsessive compulsive disorder patients,”

Bottom Line

Using DataPunk.Net we have:

Lachnospiraceae

INHIBITED BY

• High sugar diet
• Flaxseed
• Quercetin w. Resveratrol
• High fat diet

ENHANCED BY

• Walnuts
• Saccharomyces boulardii
• Saccharin

Ruminococcaceae

INHIBITED BY

• High sugar diet 
• Gallate (Tea)
• High fat diet 

ENHANCED BY

• Walnuts
• Saccharomyces boulardii
• Quercetin w. Resveratrol
• Berberine
• Saccharin 

And last,

• Lactobacillus rhamnosus GG  (Culturelle® Probiotics)

Considering that Christmas is a few days away, load up on the sugar and fat for medicinal purposes 🙂  — see disclaimer below. Not responsible for weight gain.

This is an education post to facilitate discussing this approach with your medical professionals. It is not medical advice for the treatment of any disease. Always consult with your medical professional before doing any  changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.