Using Panels Created By Others: FIBROMYALGIA DNA

User contributed panels are available, for example,

which may be added by clicking https://livewello.com/snps/library?action=preview&index=404236&for=demo for TPH2 GENE FIBROMYALGIA

  • These should always be done with a little caution because errors can happen in preparing them.

My report is below, and as expected having CFS — being likely to have FM is very common.

  • Red: 9/49 — 18% ( > 10%)– Is a concern
  • Green” 14/49 — 28% (< 45%) — Is a concern

The links to other panels and their results is at the bottom

fm

 

Looking at the associated notes, I see “This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.”

Some more FM Panels are:

So, I appear to have only one serious FM panel, two light ones and three that are excellent — which agrees with FM issues being very minor.

DNA Snp Panels — they are constantly getting bigger

At the start of this series, I posted the Methylation panel from one site which I repeat below. I also added livewello.com panel. You will notice that livewello is much bigger. If you check it again in 6 months — it may be even longer. Discoveries are always being made so the list will be longer and longer.

So, counting the number is likely the wrong way — instead go by percentage – the results will often stay the same. What you do get is more RED issues that will help to better tune you supplements.

  • Red: 1/26 (4%) on one and  6/90 (5%) – if > 10% of concern
  • Green: 17/26 (65%) on one and  46/90 (62%) – if < 45% of concern

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LiveWello.com

myth

 

 

Amy Yasko DNA Nutrigenomics

Livewello.com provides pre-written (and contributed) panels on DNA, for example,

NUTRIGENOMICS TEMPLATE WITH SUPPLEMENT RECOMMENDATIONS BY DR. AMY YASKO

To use them, you need to install it – which is easy:
Screen Shot 2015-01-05 at 9.46.41 AM
Then click the button. The results now appear. In my case — I am clear — the sole item listed is meaning less (DNA consists of (A,C,G,T) only so getting this match will happen to everyone!)
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 Which you then need to click Screen Shot 2015-01-05 at 3.41.23 PM to see the results. Mine are below
Screen Shot 2015-01-05 at 4.02.51 PM

With only a single red (1 of 27 or 4%) and many greens (18 of 17 – 66%), the Yasko approach is unlikely to have significant impact on me. So instead of trying it, I move on to something that seems better connected to my DNA.

For the single item that is in Red, I can click the item (VDR Bsm) and read what it is associated with.

Normal function:

The VDR gene provides instructions for making a protein called vitamin D receptor (VDR), which allows the body to respond appropriately to vitamin D. This vitamin can be acquired from foods in the diet or made in the body with help from sunlight. Vitamin D is involved in maintaining the proper balance of several minerals in the body, including calcium and phosphate, which are essential for the normal formation of bones and teeth…..Most VDR gene mutations impair hair growth, leading to alopecia; ”

Whether this accounts for my 1,25D levels going through the roof while I had CFS (a common occurrence with many autoimmune illness) and return to the normal range with remission — I do not know.

So the process is very easy to get the information — what you do with it is another question which usually mean joining specialized groups dealing with these specific issues. Most MDs are not trained in this very new and rapidly developing area.

Canned Coagulation factors – Testing the Hemex Model

The site https://livewello.com will take your DNA and give a variety of panels looking at various health issues. The cost is $19.95 for the processing and ongoing use of their site. One of their panels is clotting. My results are below. As you can see out of 14 reported items, 2 are red (14%) and  6 are yellow (42%).  I have a rule of thumb to filter results into ‘concern’ or ‘low concern’,

  • > 10% Red with 2 or more ==> Concern
  • < 45% Green ==> Concern

So for me, the Hemex model of having inherited coagulation issues appears to be true.

Screen Shot 2015-01-05 at 9.30.04 AM

 

On the far left is the SNPs column which are linked to more information. For example, my Red ones goes to

  • CETP ” The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins.” -“CETP SNP rs1800775 with higher LDL-C” (the bad one) – it leads to  my taking 500mg of flushing niacin daily.
  • F11 – ” TT genotypes for rs2289252 were associated with a significantly higher venous thromboembolism (VTE)”. “two SNPs, rs2289252 and rs2036914 in F11, appear to independently contribute to the risk of deep vein thrombosis (DVT), a contribution that is explained at least in part by an association with FXI levels.” This is why I take Piracetam on a regular basis (Inhibitory effect of piracetam on platelet-rich thrombus formation in an animal model.) and Turmeric Modulation of transcription factors by curcumin.

In short, if you dig into your REDs you will often find supplements that will mitigate your DNA risks. You may also find some that you should not take because while they help others, your DNA is different. The reds are the most important — but the yellow ones should also be reviewed.

Christmas and New Year reflection – pros and cons

I see I have a stack of comments as well as some phone calls to do today to some of my readers, so I will hopefully get caught up today.

Christmas can be a high risk scenario for CFS relapse

This christmas and new year ended with considerable fear in me of a potential relapse. I have been burning the candles at multiple ends (beyond both) since July with house renovations consuming weekends and weekday evenings, with practically nil time for myself.  Christmas started with pre-event stress. My wife and daughter are uber-chemical sensitive and both had flares of autoimmune that lasted months from the last family gathering attended.

On Christmas eve morning, we got a call that an over 80 close relative had been taken by ambulance to hospital. This relative usually phones before calling an ambulance — so this raised stress levels… the relative is OK now. In short the potentially CFS relapsing stressors were:

  • Stress dealing with issues of multiple over 80 relatives for which I am in the first round of support,
  • Doing dutiful eating of the wrong type of food over many days of family visits
  • Not maintaining regular exercise habit (IMHO, a key part of staying in remission)

Once we were done with seasonal activities and got home, stomach was in an upset condition, the body ache all over, waves of cold hands and feet, a decrease (but not loss of) executive decision making – more a strong preference for avoidance which is not typical for me, headaches (rare for me), psoriasis flaring badly after almost 2 years of being in remission, and 8 lb weight gain. Any (and all) of these symptoms are amber alerts for increased CFS relapse risk.

Remediation

For the last few days I have been on a 100% rye bread (no wheat gluten) and peanut butter diet (plus 1 egg/day) for breakfast, lunch and dinner, PLUS large dosages of Mutaflor (E.Coli Nissle) and bifidobacterium probiotics. I have been in the infrared sauna for an hour each day and pushing myself to do at least 1 hr of WII-fit each day. As well as these, heavy dosages of non-prescription anticoagulants(turmeric with black pepper, piracetam and other racetams, aspirin) especially fibrolytics (nattokinease, lumbrokinease, serrapetase) and 500 mg of flushing niacin (as a vasodilator).

The symptoms are decreasing quickly, including weight lost. My WII scores this morning set some new records, so the physical is coming back. Stomach is still upset a little but less so. It actually seems to become less upset after doing exercises.

Recap of Symptoms to Gut Bacteria shift

  • Increase of weight without an apparent change of diet: this implies a shift of bacteria that may:
    • Be more efficient in extracting calories from food
    • Sending signals to the body to store food (“famine signals”)
  • Body ache all over, cold extremities — this implies a shift of bacteria that sends out coagulation or vascular constriction signals (i.e. the bacteria favors low oxygen environment)
    • This is in keeping with the Berg-Hemex model/findings
  • Cognitive changes — we already know that bacteria can cause significant cognitive changes in animals and there is increasing evidence of this in human (Article)
  • Psoriasis – other autoimmune conditions will usually track with CFS risks.

Some nuggets that I found in a Christmas Present…

My wife gave me “Danish Cookbooks” by Carol Gold. This is NOT a cook book, but rather an academic study of cookbooks published in Denmark.  I’m 100% Danish and very interested in history.

I have always been inclined towards going for ancestral diet patterns, and did Paleo for a while. My problem with Paleo is that it is more idealogical based than actual (scientific) archeologically based. It is also trying to jump the diet back thousands of years which effectively ignores how our bacteria evolved to meet our changes of diet.

A diet based on typical diet of your ancestors 400 – 1400 years ago is likely a better choice. You avoid the newly introduced foods, for example, potatoes. You also avoid process foods and modern additives. On the plus side, your gut bacteria is likely closer to the optimized bacteria your ancestors evolved from eating the same food for a thousand years.

In this book, I found two gems from the historical records:

  • We have decreased the use of spice considerably — in 1600, the common spices were:
    • cumin, anise, coriander, dill, fennel, lavender, sage, rosemary, mint, bay leaves, cloves, pepper, saffron, thyme, marjoram, nutmeg, cardamon, ginger, cinnamon, hyssop, wormwood, lemon balm, angelica-root.
    • “The issue here is … the use of seasonings in general slackens” p.47
    • Many of these spices (like wormwood and ginger) have strong antibacterial characteristics which would have kept some gut bacteria families in control well.
  • “Their most common food was meat” p. 122
  • White (wheat) bread was very uncommon, expensive, and typically seen only in upper class homes on special occasions(not as part of the regular menus). It appears that most of the carbohydrates came from Rye Bread.

I am sure that some readers who favor a diet that is vegan or vegetarian on ideological grounds would object to these suggestions.  My response is simple, if your ancestors were vegetarians for centuries or millenniums (as some friends who were born in India can validly claim), then that is the right diet without any doubts.

Evidence shows that gut bacteria is inherited through generations — hence it is good to know what your ancestors ate because your gut bacteria have likely adapted to that diet. Given my heritage (which likely applies to people from the UK, Poland, northern France and Germany etc), this boils down to:

  • Rye Bread without any wheat flour
  • Meat and Fish (especially since the family seemed to always been within 5 miles of the coast back to 1500..)
  • Vegetables:

No potatoes — they really did not enter my ancestor dies until the early 1800’s – after one of my great-grandfather was born. Little or no sugar (“Worldwide through the end of the medieval period, sugar was very expensive[1] and was considered a “fine spice“,[2] but from about the year 1500, technological improvements and New World sources began turning it into a much cheaper bulk commodity.” – Wikipedia)

So I advocate not a Paleo diet, but a medieval-food diet (modified for modern nutritional perceptions).