Recent Updates Page 12

Unknown's avatar lassesen 7:22 am on December 10, 2023  

Post Exertional Malaise (PEM) with diminished ME/CFS

his is from a person that have been using Microbiome Prescription for a while with significant success. He messaged me about a new sample and asked me to take a look. It was good timing because I have over the last week refactor forecast symptoms as well as allowing them to be used to generate suggestions. This gave me an opportunity to test the analysis and suggestions.

My impression is that they are both working well with better sensitivity than the older method. Prior posts include:

Immediate Back Story

I had covid and an awful toothache a week after.

-PEM 
-Fatigue on and off specially in the morning. Lowest energy point 
-Some brain fog. If I take a binder my brain fog is much better. Guessing that could be related to mold/fungus issues?
-unrefreshing sleep
-hair shedding unless I take Lactoferrin 
-difficulty losing weight – Reader

Review of Test Results

I am skipping the sample comparison table because the forecast symptoms seem more useful for between samples comparisons.

Percentages of Percentiles

These are helpful overview to see if there are problems. At the top is a chi2 value which a healthy person should have a value below 0.90 . All of his values were .99999…. indicating abnormal shifts.

Prior to 2023

2023, the impact of COVID in the latest sample is quite apparent.

Forecast Symptoms

What shocked (and delighted) me was how accurate the forecasts were, especially with the main issue, PEM being near the top on every sample. The percentage match ebbed and flowed with improvements and set backs (typically from COVID).

  • 2023-11-02 – After recent COVID
    • 74.2 % match for Neurological: Cognitive/Sensory Overload on 31 taxa
    • 63.5 % match for Immune Manifestations: new food sensitivities on 52 taxa
    • 61.5 % match for Neuroendocrine Manifestations: cold extremities on 65 taxa
    • 60.9 % match for Neurological-Vision: Blurred Vision on 87 taxa
    • 59.6 % match for Condition: ME/CFS with IBS on 52 taxa
    • 58.3 % match for Post-exertional malaise: Worsening of symptoms after mild physical activity on 36 taxa
  • 2023-07-07
    • 57.1 % match for Post-exertional malaise: Worsening of symptoms after mild physical activity on 42 taxa
    • 54.2 % match for Condition: ME/CFS with IBS on 59 taxa
    • 48.1 % match for Post-exertional malaise: Post-exertional malaise on 54 taxa
  • 2023-05-10
    • 63.2 % match for Post-exertional malaise: Post-exertional malaise on 38 taxa
    • 59.3 % match for Post-exertional malaise: Muscle fatigue after mild physical activity on 59 taxa
    • 59.1 % match for Pain: Pain or aching in muscles on 44 taxa
    • 57.1 % match for Condition: ME/CFS with IBS on 42 taxa
  • 2022-12-05
    • 82.4 % match for Official Diagnosis: Autoimmune Disease on 51 taxa
    • 81.9 % match for Comorbid: Histamine or Mast Cell issues on 83 taxa
    • 79.5 % match for Post-exertional malaise: Next-day soreness after everyday activities on 39 taxa
    • 71.8 % match for Post-exertional malaise: Physically tired after minimum exercise on 39 taxa
  • 2022-10-29
    • 64.4 % match for Neurological-Sleep: Inability for deep (delta) sleep on 45 taxa
    • 62.7 % match for Official Diagnosis: Mast Cell Dysfunction on 75 taxa
    • 60.9 % match for Post-exertional malaise: Next-day soreness after everyday activities on 46 taxa
    • 60 % match for Condition: ME/CFS with IBS on 40 taxa
    • 55 % match for Post-exertional malaise: Muscle fatigue after mild physical activity on 60 taxa
    • 54.5 % match for Post-exertional malaise: Post-exertional malaise on 44 taxa
  • 2022-03-23
    • 85.4 % match for Neurological-Sleep: Inability for deep (delta) sleep on 41 taxa
    • 82.1 % match for Immune Manifestations: Inflammation (General) on 67 taxa
    • 77.5 % match for Immune Manifestations: Inflammation of skin, eyes or joints on 111 taxa
    • 75 % match for Post-exertional malaise: Worsening of symptoms after mild physical activity on 32 taxa
    • 71.4 % match for Post-exertional malaise: Next-day soreness after everyday activities on 42 taxa

Drilling down on PEM

With the revised symptom-taxa association tool, I went to the 2022-12-05 sample because it had very high values for PEM in forecasting. I then went to [Special Studies] and selected all of the PEM items

Some 78 bacteria were selected with the following being the top suggestions:

While this is not his current sample, it is reasonable guidance for dealing with the bacteria associated with PEM.

Going Forward

I am going to do [Just give me suggestions] and then special studies selecting only PEM items that are shown. We thus ended up with 5 packages. Looking at the details we have high at 555 -> 277 for high threshold and -542 –> -271 for low threshold

In general, it looks very pro-forma ME/CFS. He may wish to check the PEM suggestions against the details and include anything that is positive.

Bottom Line

I have often used the analogy of going from the port of sickness to the port of health in a sailing ship along a rugged coast. There may be a long series of course corrections needed. While there are still ME/CFS taxa shifts seen in his samples, subjectively the only symptom left of concern is a PEM after playing basketball for a while.

This is a good illustration that taxa/bacteria does not rule — DNA and other factors are involved with symptoms and the ability to tolerate microbiome dysfunctions.

Questions and Answers

Q: I may do another Thorne test if they’re back in stock. Wondering how much aspergillus is holding back healing/gut shifts 

  • Aspergillus usually impacts lungs and breathing [CDC] (thus ability to get oxygen in). An alternative mechanism for oxygen issues than with hypercoagulation.

Postscript – and Reminder

I am not a licensed medical professional and there are strict laws where I live about “appearing to practice medicine”.  I am safe when it is “academic models” and I keep to the language of science, especially statistics. I am not safe when the explanations have possible overtones of advising a patient instead of presenting data to be evaluated by a medical professional before implementing.

I cannot tell people what they should take or not take. I can inform people items that have better odds of improving their microbiome as a results on numeric calculations. I am a trained experienced statistician with appropriate degrees and professional memberships. All suggestions should be reviewed by your medical professional before starting.

The answers above describe my logic and thinking and is not intended to give advice to this person or any one. Always review with your knowledgeable medical professional.

Unknown's avatar lassesen 9:18 am on November 4, 2023  

Different types of Fungi and ME/CFS

This is intended to be used with reports from Thorne or Xenogene. A shotgun microbiome report is needed that reports Fungi. Most microbiome do not report fungi in detail.

ME/CFS patients show a nonsignificant increase in the ratio of fungal phyla Basidiomycota to Ascomycota, which is consistent with ongoing inflammation in ME/CFS. We did not identify specific eukaryotic taxa that are associated with ME/CFS disease status.

Eukaryotes in the gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome [2018]

Most microbiome reports use 16s technology that do not report on fungi. Fungi produces mycotoxins

Fungi are listed from lowest taxonomy level upwards.

CAUTION: Some test results may reflect foods (mushrooms) or supplements that you are consuming and could result in false high levels.

Diagram from World Health Organization fungal priority pathogens list to guide research, development and public health action

Possible Medical Plants are covered in this article: A Review: Antifungal Potentials of Medicinal Plants [2015] . e.g. Garlic and other wonder herbs do not work on all fungi. 

Unknown's avatar lassesen 2:22 pm on October 9, 2023  

New Scientist: You and Your Microbiome

“Two papers published earlier this year showed that people with chronic fatigue syndrome – also known as myalgic encephalomyelitis, or ME/CFS – have less of a gut bacterium called Faecalibacterium prausnitzii  “

The following are permissible extracts (200 words per article). Click [more] to read more…

How the microbiome changes our idea of what it means to be human

YOU may, quite reasonably, think you are an individual of the species Homo sapiens. Once you have finished reading what follows, you will hopefully have been convinced that there is far more to us than that. Trillions of other organisms live on (and, more notably, in) your body. As you will see in the reports that follow, their impact on you is such that you will probably never think about yourself in the same way again. Your microbes change who you are and what it means to be you. With knowledge of this facet of ourselves growing rapidly, exploring it has never been more relevant.

Until recently, scientists believed that there were three discrete parts of our nature that reflected solid aspects of an individual self: the immune system, the genome and the brain. “None of these pillars of the traditional definitions of the self – immunity, genome integrity, the central nervous system – are free of microbial impact,” says Thomas Bosch at Kiel University in Germany.

The microbes that colonise us, collectively known as the microbiome, challenge the concept of a discrete self. These include bacteria, viruses and fungi, although the bacteria are the best-studied. [more]

The best way to care for your microbiome to keep it healthy as you age

Your gut microbiome is a vital support system for mental and physical health, supplying the body with all-important nutrients and helping tune the immune system.  

As we get older, the balance of microbes in our gut changes. There are declines in beneficial types, such as the anti-inflammatory Faecalibacterium, and an increase in species that lead to more inflammation, which is implicated in multiple age-related conditions, including heart disease, cancer and cognitive decline. Many studies, with participants ranging from an isolated rural population in India to a wealthy semi-urban community in Italy, show striking similarities in the microbiome signatures of old age. One key finding is that people who have no significant health concerns in older age have an abundance of distinct beneficial microbes that are lost when there is a shift to physiological decline.

It isn’t clear whether the microbiomes of healthy older people are driving their vitality or are a result of the way they live, but an astonishing study in mice by John Cryan at University College Cork, Ireland, and his colleagues found that transplanting gut microbiota from young animals to elderly ones reversed age-associated impairments in brain function. [more]

Can probiotics and supplements really improve your gut microbiome?

If you have a condition like irritable bowel syndrome (IBS), a finnicky gut or just want to keep your microbiome in top condition, you might be tempted by products and treatments that offer a microbial tune-up. But what really works? Here are the main tools to engineer a better gut.

Probiotics

Probiotics are microbes that may help to restore healthy gut microbiota. If they also improve your mood, they are called psychobiotics. You can typically get them from eating naturally fermented foods like yogurt that contain beneficial bacteria, such as Lactobacillus or Bifidobacterium.

But as an adult, these microbes are unlikely to colonise your intestines. To the extent that they are helpful, their benefit comes while they are passing through. Such probiotics stimulate immune cells in the gut to reduce inflammation, increase mucus production and deter pathogens by producing lactic acid. But as mere visitors, they need daily top-ups.

Probiotic supplements have been used (with mixed success) for more than a century to help with the gut conditions of Crohn’s disease, colitis and IBS. They have also been shown to help with weight loss in people who are overweight and are increasingly being used for other conditions… [more]

Secrets of a long and healthy life reside in your gut microbiome

WHY do we age? As youngsters, we seem invincible. We climb trees, frolic in the dirt and blithely share alarming quantities of mucus. At college, we can thrive on a diet of ramen and beer, party all night and still sit an exam the next day. But in our 30s, we start to wind down. It becomes harder to maintain muscle tone and avoid illness. Our joints start to ache and our memory begins to dim. And it is mostly downhill from there.

People have long attempted to stop or reverse this process. But fountains of youth and secrets of immortality remain firmly in the realms of fiction. Our bodies wear out, even if we no longer do the back-breaking physical labour our ancestors did. And the world seems determined to grind us down with a plethora of disease-causing microbes. To help fend off these pathogens, our bodies recruit other microbes, vast numbers of which reside in our intestines, where we feed them in exchange for their services. But, as we age, this gut microbiota becomes less effective at fighting diseases too. [more]

Where does your gut microbiome really come from – and does it matter?

Imagine a remote island, recently formed by volcanic activity, in the middle of the ocean. At first, it is lifeless, but a growing variety of plants take hold, providing food for pioneering animal species, until eventually there is a diverse and flourishing ecosystem.

This is a useful way to think about how our gut ecosystems develop. “Your microbiome goes on a journey,” says Alan Walker at the University of Aberdeen, UK. “When you’re born, some bugs get in and then, when you start eating solid foods, other bugs replace them. There’s a dynamic process where your microbiome changes until you get to mid-to-late childhood. Then, through adult life, you’ve got a reasonably stable microbial community.”

Does a C-section affect a baby’s microbiome?

The first individuals that colonise an island can have long-lasting influences on its ecosystem, an idea known as the founder effect. Until recently, the thinking went that if the founder bacteria in a baby’s gut were unusual – because the baby was born by Caesarean section, for instance – this might disrupt their bacterial ecosystems. This idea has led some parents to take radical steps to get their children’s microbiomes back on the right track.  [more]

What is the role of the microbiome in diseases like chronic fatigue

ONE of the most compelling discoveries about the gut microbiome is its influence on the immune system. Between 70 and 80 per cent of immune cells are in the gut, where they are constantly communicating with microbes. This crosstalk helps fight disease, strengthen immune responses and regulate inflammation, our body’s first line of defence against infection. Controlling inflammation is critical, as too much damages cells and helps drive chronic illness.

It is no surprise, then, that a growing body of evidence implicates the gut microbiome in various chronic diseases, from arthritis to Alzheimer’s. It is still early days, and most of these findings only point to associations. But they raise the possibility that gut microbes may contribute to, or even cause, some of our most intractable conditions, an idea that has already inspired new treatments.

It is now well established that gut microbiomes in people with conditions like multiple sclerosis, type 1 and type 2 diabetes, Parkinson’s disease and even asthma differ significantly from those of people without an underlying illness. Two papers published earlier this year showed that people with chronic fatigue syndrome – also known as myalgic encephalomyelitis, or ME/CFS – have less of a gut bacterium called Faecalibacterium prausnitzii  [more]

How your microbiome is shaped by your friends, family, lovers and pets

When we are born, we get most of our gut microbes from our mothers (see “Where does your gut microbiome really come from – and does it matter?”). But as we get older and form other close relationships, including with intimate partners, friends and pets, we start to pick up their microbes too. This could potentially affect our risk of developing conditions like obesity, inflammatory bowel disease, asthma and allergies (see “What is the role of the microbiome in diseases like chronic fatigue?”).

“I jokingly say that your dating app profile should include your microbiome profile,” says Brett Finlay at the University of British Columbia in Canada.

The strongest evidence comes from work published in January by Mireia Valles-Colomer at the University of Trento, Italy, and her colleagues, who conducted the largest study to date of how our gut microbiomes are shaped by the people around us. They analysed DNA in the faeces of more than 7000 people from households around the world, including rural parts of Africa and South America and cities in the US, Europe and China, to find out which bacterial strains were in their guts and what proportion they shared with others. [more]

—————– from older issues ———————-

Your gut microbiome is linked to your fitness and biological age

The diversity of microbes in the gut could affect a person’s fitness and their biological age. Better understanding this may one day lead to probiotics that alter the gut’s microbial make-up to promote health.

Zsolt Radak at the Hungarian University of Sports Science and his colleagues studied 80 amateur rowers, aged 38 to 84, who participated in the 2019 World Rowing Masters Regatta in Velence, Hungary.

The rowers, whose training regimens ranged from practising every day to once a week, each provided a stool sample to identify the bacteria in their guts. The researchers also took blood samples to gauge the participants’ biological ages – a measure based on DNA markers, rather than the number of years someone has been alive.

The researchers found that having higher levels of gut microbiome diversity was linked to lower levels of fitness and an accelerated rate of biological ageing. This somewhat goes against previous research that linked lower gut microbial diversity to conditions such as obesity and type 2 diabetes. [more]

Unknown's avatar lassesen 11:41 am on September 29, 2023  

Update #4 on ME/CFS Person

The person in this prior post has done a retest. This analysis looks at what changed from selectively following suggestions from this prior post.

His comments are below:

“Things that I have been taking since the last test in February 2023:

  • Rosemary
  • Grapefruit seed extract
  • Turmeric
  • Natto 
  • Tetracycline 
  • Clove
  • Anise
  • Acacia gum 
  • Amoxicillin 
  • Apple peel powder
  • Thyme
  • Symbioflor 2
  • Neem 
  • Jarlsberg cheese

My symptoms:

  • Still get the red nose (some form of rosacea). But it is better than before.
  • Still feel fatigued (both physically and mentally). But it is better than before.
  • Feeling stressed. But it is better than before.
  • Brain fog.
  • Bloated.
  • Lots of gas – I fart and burps a lot. “

This is his fifth sample. Multiple samples are not unusual because fixing the microbiome means a lot of course corrections.

Analysis

First, we will look at measures that were not available for the earlier posts. In the last period, we see a dramatic change of the histamine values!

SampleAnti-Inflammation ValueHistamine Value
2021-08-3197%ile98%ile
2021-12-03 96%ile98%ile
2022-03-2518%ile87%ile
2022-08-1130%ile90%ile
2023-02-2265%ile86%ile
2023-09-1287%ile3.2%ile

We also see a dramatic change in the Percentages of Percentiles charts that suggests improvement. In fact, there is no longer any statistically significant shifts (going from 0.99999… to .40!). Dropping below 0.95 is an objective target. The pattern went from the common ME/CFS and Long COVID pattern to an normal pattern.

Potential Medical Conditions Detected

We have the following candidates to consider that were not flagged in the prior sample (where nothing stood out):

  • Allergic Rhinitis (Hay Fever): 100%ile
  • Stress / posttraumatic stress disorder: 98%ile
  • Irritable Bowel Syndrome: 97%ile

This may be just randomness or because the microbiome is calming down, patterns hidden by noise are showing up. Looking at Special Studies pattern matching, the top one was COVID19 (Long Hauler) at 28% match (prior was 41% match) — a definite improvement. Other items dropped about 8% match each, most were so low, that there may not be significance.

These appear to agree with his personal observations. We have Prevotella copri is at 76%ile, hinting that mycotoxin present (mold) may be in his environment (see this post for more exploration).

Going Forward

In terms of subjective and objective measurements, this person has improved. So time for the next course correction. I am going to just run with the “just give me suggestions” since nothing really stands out.

The non-prescription items from the PDF are by far the shortest that I have seen! So the safflower may be difficult because it does not mean safflower oil (an avoid), but the herb.lots of coffee and perhaps a little Aalborg Aquavit.

In terms of probiotics, he lucked out — Filmjölk is likely available to him

The avoid or reduce list is much longer!!

Going over to items computed from the Kyoto Encyclopedia of Genes and Genomes we have the top item being the typical one for ME/CFS: Escherichia coli (i.e. Mutaflor or Symbioflor-2). In terms of supplements, the two most significant one are: Glutamine, Threonine, Serine.

Since the person has a co-operative MD (i.e. two antibiotics were listed), I reviewed the prescription items. The top item was amoxicillin (antibiotic)s[CFS], which has already been used. We have gatifloxacin, ciprofloxacin (antibiotic)s[CFS], and clinafloxacin (antibiotic) which is a different family (a fluoroquinolones which has a lot of bad press). The next one worth considering is nadifloxacin (antibiotic): Nadifloxacin is a broad-spectrum quinolone antibiotic(in fluoroquinolones family) that has been approved for use in the treatment of acne vulgaris and skin infections. This may impact his rosacea. The next one down the list may be similar: fusidic acid sodium salt (antibiotic).

One factor to consider is that Cecil Jadin has been using fluoroquinolones for twenty years without seeing any adverse effects. The duration is only 10 days or less. Longer duration of use may be a significant factor. See this post and video for more information.

Questions

“All those antibiotics MUST be taken: after food ( not only water ) and without any dairy products. Patients must avoid sugar intake and some supplements(for example magnesium). Antibiotics should be taken in the morning and the evening. Patients must avoid sugar intake and supplements.”Cecile Jadin, MD  Video Presentation of Dr. Jadin’s Current Protocol for ME/CFS, Q-Fever, Chronic Lyme and related conditions

Q: I’m going to do another round with  amoxicillin.
— In Jadin’s presentation she says to only take it for 7 days, ain’t ok to take it for 14 days as we talked about before?
— Can’t I take other supplements like magnesium when I take antibiotics?

  • A: The duration range of 7 – 14 days is, IMHO, fine. My main concern is long duration that can result in antibiotic resistance.

Q: If I want to have a longer list for what to take / avoid, can I use the three that is blue below (as earlier)?

  • A: What is shown above is from the PDF which I am preferring to use for posts because it keeps things simpler. You can do any combination you wish. You could also consider doing your last sample suggestions and this sample suggestions, an “uber consensus” which should produce suggestions of what has been out of range with both samples. Caution should be done because of how different the two samples are!

This does produce a massive list!!

I would then go thru the list and cross out items that are not shown with at least 7 of the possible 8 in the technical details.

Bottom Line

My own experience with recovery was that it took about a year for many symptoms to wear off. The body is not an electronic device with an on/off switch; think of a meadow that has been damaged by fire, flood, or chemical spill — it takes time for things to come back.

Postscript – and Reminder

I am not a licensed medical professional and there are strict laws where I live about “appearing to practice medicine”.  I am safe when it is “academic models” and I keep to the language of science, especially statistics. I am not safe when the explanations have possible overtones of advising a patient instead of presenting data to be evaluated by a medical professional before implementing.

I can compute items to take, those computations do not provide solid information on rotations, dosages, etc.

I cannot tell people what they should take or not take. I can inform people items that have better odds of improving their microbiome as a results on numeric calculations. I am a trained experienced statistician with appropriate degrees and professional memberships. All suggestions should be reviewed by your medical professional before starting. Some suggestions may be counterindicated for other medications you are taking and medical conditions.

The answers above describe my logic and thinking and is not intended to give advice to this person or any one. Always review with your knowledgeable medical professional.

Unknown's avatar lassesen 6:49 am on September 28, 2023  

ME/CFS da molto tempo dopo i fluorochinoloni

I encourage people that can translate any of my pages to a different language to do so. You have my permission (provide the site is open access and free). Many people with ME/CFS do not English and thus cutoff from both scientific literature and this blog.

I would encourage people that also have technical skills to create a FREE word press site (ideally with a name like CFSRemission-IT.Wordpress.com (the ending letters being the language). I will gladly provide links to such site on this site.

———————————————————————————-

Questo proviene da un lettore con cui sono in corrispondenza dal 2017 e che conosco da gruppi online da decenni..

Ok, non vuoi l’intervista completa 😀 (scherzando) e quindi scriverò le prime impressioni attuali di un paziente ME/CFS dal 1998 . Sono qualcuno che ha provato di tutto; davvero di  tutto .
Innanzitutto, come vi avevo già raccontato in chat, utilizzo come criterio di miglioramento della malattia l’aumento del tono cardiovascolare, cosa che in realtà è avvenuta per poco tempo fintanto che ho mantenuto una dieta non proprio ferrea, ma molto difficile per me: comportava l’eliminazione di tutti gli zuccheri raffinati.

Per chi fosse interessato, ne ho parlato qui: https://www.fable.it/fluorochinoloni-hrv-dieta-e-me-cfs/ (in italiano – usa Google Translate). Per i primi sette giorni di dieta non è cambiato nulla, niente! Dopo questi 7 giorni improvvisamente, attenendomi a questa dieta, il tono cardiovascolare ha iniziato ad aumentare fino a quando… beh… ho mantenuto il resto della dieta ma ho reintrodotto gli zuccheri (ma non l’alcol). Quindi il miglioramento si è interrotto (ma sono stati mantenuti i miglioramenti esistenti).

Da Lettore

Gli eventi significativi recenti sono:

  • tossicità dei fluorochinoloni nel 2020
  • integratori di akkermansia muciniphila un mese prima dell’ultimo campione (vedi sotto per la sua esperienza)
  1. Risultati dei vecchi test 

Di seguito è riportato il risultato del test del 23 agosto 2016. Il test riguarda solo pochi batteri senza alcun intervallo di validità normale. Confronteremo i pochi elementi riportati con l’ultimo test Biomesight. Ci sono stati pochi cambiamenti in 7 anni.

Immagine che contiene testo, ricevuta, numero, schermata Descrizione generata automaticamente
  1. Eventuali effetti persistenti da fluorochinoloni?

Ho effettuato un confronto dietro l’interfaccia utente di ciò che i fluorochinoloni sono cambiati con il suo campione. Anche se sono passati 3 anni, sono curioso. Nessun impatto avrebbe un risultato 50-50. Abbiamo 64 batteri che mostrano l’effetto che i fluorochinoloni causerebbero e 43 che mostrano l’effetto opposto. Ciò si traduce in un valore P di 0,0423 dal chi quadrato. Un valore P inferiore a 0,05 è ritenuto statisticamente significativo negli studi medici. Quindi, questa è la prova che l’impatto dei fluorochinoloni è ancora presente dopo 3 anni .

Questa è un’osservazione interessante: scegliere l’antibiotico sbagliato può avere effetti che persistono per anni.

  1. Confronto con il test precedente mostrato sopra

Ogni laboratorio utilizza le proprie metodologie per le misurazioni (vedere L’incubo della tassonomia prima di Natale… per il motivo e Confronto dei microbiomi di tre diversi fornitori per un esempio reale). Quindi non possiamo determinare se i livelli sono saliti o scesi.

Il microbioma è rimasto relativamente stabile per 7 anni. In effetti, il test Biomesight chiarisce quanto estremi siano i valori (cosa che non risultava chiaramente dal rapporto precedente).

  1. Dove andiamo da qui?

Il modello della percentuale di percentili mostrato di seguito corrisponde a quello osservato con molti microbiomi ME/CFS o COVID lungo.

Spiegazione nerd : utilizzando i percentili, i dati vengono trasformati in una distribuzione uniforme. Un campione imparziale (ovvero normale o sano) avrebbe lo stesso numero in ciascun intervallo del 10%. Noi non. Abbiamo il picco tipico nell’intervallo 0-9% (cioè troppe specie e generi che hanno una rappresentazione simbolica ).

Immagine che contiene testo, schermata, software, Icona del computer Descrizione generata automaticamente

Il batterio più importante/riguardante identificato è stato Prevotella copri . Questo batterio costituisce il 43% del microbioma!!!! Questo batterio è spesso associato alla presenza di micotossine nell’ambiente [ 2020 ]. Questo di solito significa esaminare lo spazio abitativo per individuare muffe e funghi, oltre ad evitare cibi che potrebbero contenere muffe (vedi OMS per maggiori informazioni). La sua risposta a questo commento è stata:

Sì, vivo in un appartamento esposto a nord dove non c’è mai il sole sui muri. Solo in una camera non più utilizzata come camera da letto è presente della muffa visibile (foto allegata). Ho provato a trattare con candeggina al cloro. Nel febbraio 2023 ho chiamato un pittore. Ha trattato con soluzione antimuffa e pittura termica (che può essere pericolosa. Non avrei mai abitato in quella camera finché non fosse sparito l’odore.
E sì, il sole mi ricarica e non so se intacca anche le micotossine. Comunque nel mio quartiere  / zona in cui vivo, non abbiamo mai meno del 60% di umidità , ma in estate solitamente abbiamo il 70-75%quindi… l’umidità è una preoccupazione.

Da Lettore

Ci sono molti siti che forniscono suggerimenti su questo problema, alcuni sono: [ Aircare Hawaii ] e questo

La muffa è legata all’umidità?
Le case europee e italiane sono tipicamente costruite con telai in cemento armato e pareti in mattoni.
Le superfici delle pareti e del soffitto sono rifinite con malta/intonaco e vernice a base acqua. Poiché
le idropitture non sono impermeabili, le finiture ad intonaco tendono ad assorbire e trattenere l’umidità. Queste zone possono
diventare umide o bagnate a causa di una perdita d’acqua o della condensazione dei vapori prodotti dagli elettrodomestici
e dalle normali attività domestiche.

Da https://www.aviano.af.mil/

L’uso di una vernice impermeabile dopo la pulizia (e l’utilizzo di un deumidificatore) nella camera da letto è un approccio possibile. Il lettore ha risposto (con sua gioia) che è stata utilizzata vernice resistente all’acqua!

Questo, oltre ad altri cambiamenti, corrisponde a una serie di condizioni mostrate di seguito. Molti sono in comorbilità con la ME/CFS.

Immagine che contiene testo, schermata, software, numero Descrizione generata automaticamente

I probiotici calcolati di KEGG Enzymes avevano numeri molto alti (oltre 600!). Numeri elevati significano che il numero di molti enzimi è molto basso. Alcuni di questi sono disponibili nei probiotici, con i migliori suggerimenti fattibili:

Due probiotici venduti al dettaglio per il Bacillus di cui sopra sono: Energybalance / ColoBiotica 28 Colon Support e microbiome labs/ megasporebiotic . La persona si trova in Europa, quindi sono disponibili i due probiotici E.Coli: Symbioflor-2 e Mutaflor. Per altri, vedi Miscele probiotiche .

Rimanderò il resto dei suggerimenti al PDF, allegato di seguito. È interessante notare che i probiotici di Akkermansia muciniphila sono ben raccomandati (vedi esperienza di seguito).

In questo caso, abbiamo avuto una buona esperienza positiva con i lettori prima che venisse fatto il suggerimento! Dovrebbe incoraggiare il lettore a fidarsi degli altri suggerimenti (dopo tutto, “un suggerimento ha funzionato prima di riceverlo!” 🙂)

Scarica europeo

Ho anche guardato la versione MD che suggeriva alcuni antibiotici:

Nessuna di queste è tipicamente utilizzata per la ME/CFS (ma altre tetracicline lo sono). Abbiamo un unico grande obiettivo: P.Copri. Spero che tu abbia un medico cooperativo. Ho cercato informazioni sugli antibiotici che spesso hanno scarsi effetti su P.Copri, questi studi hanno elenchi estesi.

  1. Esperienza Akkermansia Muciniphila

Un’altra cosa, Ken, è la scoperta sensazionale quest’anno dei probiotici Akkermnasia (nel mio caso della Metagenics). Nei miei primi due giorni sono passato dall’andare in bagno una volta al giorno ad andarci tre quattro volte. Quante volte abbiamo letto che un normale transito intestinale prevede da 1 evacuazione al giorno ad una ogni 2-3 giorni? NO ! Il transito ideale è andare in bagno circa mezz’ora dopo aver mangiato! Ebbene, questo mi è successo mentre assumevo Akkermansia una volta al giorno. Ed è solo una varietà!!! Non solo quello ! Mi sentivo meno “lotta o fuga” ma più sereno, anche quando mi svegliavo dal sonno notturno. Anche con croste sugli occhi che chissà da quanti anni non trovo (quante di noi hanno gli occhi perennemente asciutti?). Ho interrotto l’integrazione dopo un mese e ora la sto riprendendo.

Perché ti scrivo questo Ken? Per perdere tempo!!! No, ti scrivo perché avevo letto per la prima volta di questa Akkermansia tre anni fa sull’etichetta di un prodotto austriaco, Omni Logic Plus, che contiene un sacco di cose buone (FOS, GOS, ecc.) per alimentare questo specifico batteri, Akkermansia. Tre anni di integrazione ogni giorno non hanno migliorato nulla.
Dopo appena pochi giorni di Akkermansia, ovvero la varietà che quell’Omni Logic Plus avrebbe dovuto nutrire, ha fatto il miracolo! Cosa intendo con tutto questo? Quello che penso è che invece di agire sul cibo, se sono disponibili come integratori, dovrebbero essere introdotti piccoli ceppi batterici, per un effetto molto migliore.

Da Lettore

  1. Domande:

D: Quando sono presenti i “nutrienti” dei batteri soprannumerari, questi crescono. Se si eliminano i loro nutrienti, l’effetto sulla diversità del microbiota è estremamente “reattivo”!!! È successo quando ho tolto gli zuccheri?? Sei d’accordo con il mio ragionamento?

  • R: Sì, considera una popolazione umana ben nutrita (anche obesa). Se improvvisamente imponi loro un rigido razionamento, il loro comportamento cambia notevolmente (spesso con azioni criminali).

D: È più efficace rimuovere il cibo che alimenta i batteri sovrarappresentati e contemporaneamente integrare i ceppi sottorappresentati non tanto con la dieta e il cibo, ma con i probiotici?
Un esempio del mio caso personale? Quando nel report generato dal vostro sito vedo tra i consigli il clostridium butyricum , che non ho mai provato in vita mia.

  • R: Gli algoritmi lo fanno effettivamente: identificano il materiale che inibisce i sovrarappresentati e che non ha un impatto sui sottorappresentati. Anche il contrario, nutrire i sottorappresentati senza nutrire i sovrarappresentati. Puoi provare a calcolarli manualmente, ma è un’enorme quantità di letture e ricerche. Microbiome Prescription utilizza circa 1,8 milioni di fatti estratti da quasi 12.000 studi.

D: Chissà se può darmi gli stessi benefici di Akkermansia? Dopo anni trascorsi settimane intere, ho provato vari prodotti. Come tutti gli altri, ho speso centinaia di euro. Per esempio:

  • Probactiol duo (miliardi di Saccharomyces boulardii)
  • 8,5 miliardi di una miscela probiotica – miscela Howaru (Lactobacillus acidophilus NCFM®, Bifidobacterium lactis Bi-07®, Lactobacillus paracasei Lpc37™, Bifidobacterium lactis Bi-04™)
  • R: Lo scopo di Microbiome Prescription è calcolare quelli più probabili in base al tuo microbioma e quali studi riportano gli effetti dei vari probiotici. Ciò significa maggiori probabilità di effetti positivi! Molto meglio (e più economico a lungo termine) che provare cose suggerite dagli influencer o che hanno funzionato per qualcuno con un microbioma molto diverso.

La tua lista è molto breve: il 50% è ciò che hai scoperto di recente funziona!!

Immagine che contiene testo, Carattere, schermata, algebra Descrizione generata automaticamente

Per i probiotici , eseguirne uno alla volta per 10 giorni, quindi passare a un altro. Perché? Il loro effetto è spesso dovuto agli antibiotici naturali che producono. Il loro mantenimento continuativo consente lo sviluppo della “resistenza naturale agli antibiotici”.