A reader wrote “Having some great results from the probiotic therapy especially with respect to the reduction of depression, morbidity, binge eating, inability to maintain weight and cognition and energy somewhat. Still no relief with respect to sleeping I still only sleep a 2-3 hours of deep sleep..”
I am very pleased my approach is working for at least one other. I am going to write about my research and thoughts on the sleep problem.
My training is in mathematical modelling which includes data reduction — to translate into terms more real to CFSers: I take some 80+ common symptoms and find that they could be reduced to symptoms from 8 states. Then I look at the 8 states and find that they could be reduced to the direct or collateral effect of one or two conditions – namely a dysfunction microbiome AKA a cartel of evil gut bacteria.
In my 1999 onset, I found that many CFS symptoms were found to match that of hypoxia (or oxygen starvation). The hypoxia does not need to by systemic, but may only be to the brain. Wikipedia lists the following symptoms:
- light-headedness / fatigue,
- numbness / tingling of extremeties,
- nausea and anorexia
- confusion / disorientation / hallucinations / behavioral change,
- severe headaches / reduced level of consciousness,
- pulmonary hypertension
- bradycardia / cor pulmonale and
Let me see… CFSers have often been referred to as “greys” (as in ETs) – wait that pallor! I will not bore the reader by citing the dozens of PubMed studies and Conference reports that have the same symptoms reported for CFS. The most common cause of hypoxia is climbing the Andes or Mt. Everest, which does not apply here.
Hypoxemia means low oxygen levels in the blood and is known to decrease sleep quality with frequent sleep arousals.
What does apply are the following conditions which can lower oxygen delivery levels (thus causing hypoxia). The key word is delivery – your blood may have normal oxygen levels per ml of blood, but if it’s flow is 30% then normal — you will only get 70% of the normal level of oxygen delivered.
- Coagulation (“thick blood”) – blood flow is slow
- Vascular constriction – blood vessels tighten
- Inflammation – tissue are sworn and impede the flow of everything (the purpose of inflammation is to slow the flow of pathogens until the body can mount a defense).
All of those triggers could be caused by chemicals (signalling molecules) produced by cartel gut bacteria. So if you nail the offending bacterias, then all three would reduce and hypoxia may disappear and a good night sleep may happen.
The gotcha is how long these artifacts persist. I will only cover one in this post, coagulation.
Taking with David Berg, I recall him telling me that soluble fibrin monomers(SFM) were the most common coagulation indicator in CFS patients. These monomers can form weak meshes in the blood and may lead to misshapen red blood cells reported by Les Simpson in Journal of IiME, Vol. 2 Issue , p. 24ff. as the red blood cells are squeezed thru them. Treating “thick blood” very much depends on why it is thick (coagulation and it’s control is a multiple step process — each process needs different treatment! 😦 ). The outcome of have SFM can be fibrin deposits which acts as barriers to red blood cells reaching tissues.
So, assuming the best case scenario (and what has worked with me):
- Breaking down the SFM (no studies, just reported observations and own experience – via my labs)
- Up to 8 “00” capsules of turmeric /day
- Up to 8 800mg tablets of piracetam /day (not close to bed time – it also stimulates the mind)
- Dissolving old fibrin deposits:(see this earlier post)
Another cause of thick blood is platelet activation. This can be reduced by aspirin, grape seed extract, etc — it is very easy to OVER CORRECT this, resulting in a scratch bleeding very easily and very long. Many many herbs inhibit platelet activation – so some careful research is recommended.
Another item that helps blood flow is alpha lipoic acid (ALA) with some 82 PubMed articles.
Lastly, I have found that Magnolia Bark – an adaptogen with known impact on some bacteria — taken one hour before bed, seems to also help with sleep
- Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice. 
I hope this post will put you to sleep!
P.S. As always — consult with your medical professional before making and changes in supplements. Any sign of easy bruising or bleeding requires prompt medical assistance (and immediate stopping of any and all anticoagulants).