A forgotten treatment for fibromyalgia/chronic fatigue syndrome?

While researching another topic, I came across this from 1998, Effects of  vaccine on pain and fatigue in patients with fibromyalgia/chronic fatigue syndrome. This is logical (just need the RIGHT vaccine) from observations made in my last post.

” Significant improvement was seen in seven of the 15 CPRS items in the vaccine group when pretreatment values were compared to post-treatment values. In CPRS <<fatiguability>>, there were significant intergroup differences, and in CPRS <<pain>> intergroup differences bordered on significance….  In a follow-up study of 23 patients, thevaccine treatment was continued for 2-6 years. Fifty percent were rehabilitated successfully and resumed half-time or full-time work.”

This was followed up with a 2002 study. ” The treatment was well tolerated. Intention-to-treat analysis showed 32/49 (65%) responders in the SB(vaccine) group compared to 9/49 (18%) in the placebo group (P<0.001). … An increase in CPRS symptoms at withdrawal was noted in the SB group. In conclusion, treatment with staphylococcus toxoid injections over 6 months led to significant improvement in patients with FM and CFS. Maintenance treatment is required to prevent relapse.” [2002]

“One hundred and sixty patients with Fibromyalgia and Chronic Fatigue Syndrome, who were on a continuous treatment with a Staphylococcus vaccine, were followed during one year with repeated consultation visits…. showed improvement from start of treatment and also further improvement during the follow-up year. In view of the natural history for these disorders the result is of interest.”[2006 article in Journal of Chronic Fatigue]

Discussion from 2010 on Phoenix Rising.


  • Polyvalent vaccine targets antibiotic resistant strains of S. aureus
  • Provides protection against the most common strains of S. aureus
  • Targets toxins secreted from S. aureus
  • Mechanism of action targets surface proteins

1937 Paper is here.

The vaccine is available for veterinary use.

Bottom Line

It is worth while for a researcher to explore producing a series of vaccines for overgrowth species/strains in CFS/FM. It may be possible to do this with a similar method as was used in the 1930’s (i.e. not high tech). The 50% success rate seen in multiple studies is in line with a microbiome dysfunction that is multiple species — thus any single item will likely only be partially effective.

Recent literature and reports on the vaccine itself (National Institute of….):

Fast Track Clinical Trials (not for CFS):