Increasing Parabacteroides Distasonis

In Ian Lipkin et al 2017 study, low Parabacteroides Distasonis was reported (on average) between CFS patients and controls. [Index to all posts on Study] .

  • “PIC and constipation-predominant irritable bowel syndrome(C-IBS) promoted changes in the gut microbiota, characterized by increased relative abundance of Bacteroides ovatus and Parabacteroides distasonis in both models.” [2017]
    • What! Do we have other research disagreeing with Lipkin’s? Not quite, his study did not separate IBS and C-IBS, his bad.
  • ” inoculated male and female germ-free C57BL/6J mice with fecal bacteria from a man with short-term vegetarian and inulin-supplemented diet.  The relative abundance of 13 OTUs were higher in males, such as Parabacteroides distasonis and Blautia faecis, while 33 OTUs were overrepresented in females, including Clostridium groups and Escherichia fergusonii/Shigella sonnei.” [2016]
    • Again, another short coming of Lipkin’s study — no separation between males and females! Seeing this difference of microbiome occurring without an illness involved, implies that gender may be a significant factor! 
  • Rhizoma Coptidis (RC) alkaloids ..whereas, the abundance of Escherichia coli, Desulfovibrio C21_c20, Parabacteroides distasonis was suppressed.” [2016] This is also known as Coptis Root or Huang Lian.
  • “Relative to its baseline, the high red meat  (HRM) + high-amylose maize starch (HAMSB) diet increased the excretion of SCFA by over 20% (P < 0.05) and increased the absolute abundances of the Clostridium coccoides group (P < 0.05), the Clostridium leptum group (P < 0.05), Lactobacillus spp. (P < 0.01), Parabacteroides distasonis (P < 0.001)” [2015]
  • Found in sphagnum-dominated peatlands [2015] – ancestors using peat for fuel would likely be consuming this bacteria (probiotic) naturally.
  • ” The tests showed that imipenem, meropenem and chloramphenicol were the most effective antibiotics (98%, 98% and 92.16% of susceptibility, respectively) followed by ticarcillin/clavulanic acid, piperacillin/tazobactam, rifampin (88.24% susceptibility), moxifloxacin 86.27% and tigecycline 84.31%.” [2014]
  • “we performed a comprehensive culture based analysis of intestinal biopsies from pediatric Crohn’s disease [CD], ulcerative colitis [UC], and control subjects… Parabacteroides distasonis significantly decreased in inflamed tissue.” [2013]
  • “At the species level, the changes evoked by resistant starch Type 4 (RS4) were increases in Bifidobacterium adolescentis and Parabacteroides distasonis,” [2010]
    • See the Definitive Guide to Resistant Starch for more information. This is “man-made and formed via a chemical process.” Examples: Distarch phosphate and “hi-maize resistant starch.”

Bottom Line

I find Lipkin’s report here to be suspect. Too many other studies suggests that low is good — but the common thread of doubt between his and other studies is the lack of analysis by gender which appears to be a significant factor for this bacteria..