A reader wrote:
At a high level, we see metabolism has moved closer to normal but concerning:
- symptoms have increased
- all profiles have increased
despite the subject report of improvement. Symptom reporting tend to be unreliable because if a few symptoms dominate in severity, less symptoms may be reported When Symptoms are less severe, more may be noticed.
Concerning profiles, see below:
|Sample Id||Dec 2017||April 2018|
|* All Profiles||117||151|
|* Metabolism Average||0.96||0.98|
|* Metabolism Std Dev||0.20||0.21|
|Chronic Fatigue Syndrome||9||15|
|High Blood Pressure||3||3|
|Histamine Issues From Ubiome||5||5|
|Inflammatory Bowel Disease||4||5|
|Irritable Bowel Syndrome||4||5|
|Systemic Lupus Erythematosus||14||15|
|Type 2 Diabetes||4||6|
The only symptom that showed significant improvement was ADHD, a proxy for the ability to focus (which agrees with feeling good enough cognitively to seek writing work).
A followup email potentially explained what is happening.
“I stopped taking almost anything that wasn’t on my take list, especially vitamin d because I remember seeing it promoted bifidobacteria. I took melatonin and valerian throughout purely to help me sleep, a lot of monolaurin as it was a recommendation and for possible antiviral benefits, and curcumin (if I stop taking it I get really bad lower back pain). I took Lactobacillus gasseri for two weeks (made me feel great while taking it) and symbioflor 2 for 1 week which also made me feel better but less so.
Going forward Recommendations
#2 For dealing with HIGH counts — there was nothing on the default recommendations. When I changed to LOW counts, a lot of things appeared. (Remember — the original recommendations ONLY dealt with High counts, the site has evolved from there).
REMINDER: the numbers are NOT the degree of effectiveness, they are the confidence that this would change bacteria based on the number of studies reporting it. Olive Oil may be 100x better than inulin — but inulin has 4 times the number of studies!!! In general, relative effectiveness is not available in studies. Studies are usually, “Olive oil decreases…..”
As a result of this, I modified my profile summary page to report high and low separately, as shown below:
Clearly, most of the change was due to more bacteria dropping below normal, almost a 35% increase in low counts.
Hand Curated List
I am trying not to do this (time consuming and only benefits one person), but in this case it may be of general benefit. The settings I used was LOW COUNTS, not aggregated, some evidence; then it’s common sense or remember this or that odd fact from reading.
- Given some extract (often sold as a supplement) and the real whole food that contains it, I always favor the real whole food!
- Apples — especially Pink Lady
- Black raspberry
- Jerusalem artichokes / Inulin
- Sea Weed — snacks or supplement
- choline supplements
- fish oil
- barley and oats porridge for breakfast
- bacillus coagulans
- clostridium butyricum miyairi probiotics
- General Biotics’ Equilibrium
- lactobacillus acidophilus
- lactobacillus reuteri
- Prescript Assist
- saccharomyces cerevisiae
- No Vitamin D (which is usually part of the standard recommendation 🙁 )
- L-Taurine supplements
- Stevia, sulfites
- bifidobacterium longum bb536
- lactobacillus rhamnosus
The earlier recommendation targeted at high counts only, appear to have worked based on two pieces of evidence:
- Subjective report from reader (Improving from a 10 down to a 5 for severity)
- No recommendations for high counts!
We are now moving over to repopulating the low counts. Once that is done, we may find that another adjustment is needed. It is not a one-step linear path to rebalance the microbiome.
This is an education post to facilitate discussing this approach with your medical professionals. It is not medical advice for the treatment of any medical condition. Always consult with your medical professional before doing any changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.