What is human sourced probiotics and why do we care?

If you look at different strains of a probiotic such as Lactobacillus Reuteri and dig far enough into research papers — you will see charts like the one below.

From prediction to function using evolutionary genomics: human-specific ecotypes of Lactobacillusreuteri have diverse probiotic functions[2014].

All strains of a Species are not created equal

As you can see above: some produce histamine, some produces folate and produce high amount of Reuterin (the natural antibiotic against infections). For many people, the ideal Lactobacillus Reuteri probiotic would be a folate producer, with no histamine and hgh Reuterin production. This excludes the fact that we also should care about the source.

Interspecies Probiotics do not take up residency

If you look at the above chart, and look at history: all of these creatures have co-existed with mankind (and each other) for millenium. It appears that some strains may be shared between chickens and humans – it’s unusual. There are no common strain between any of them. We know bacteria gets transferred by a kiss (see this post Kisses, Sex and FM/CFS/IBS ) and some intake of bacteria from these creatures would occur…. but none have ever taken up residency.

In Species Probiotics MAY take up residency

This has been demonstrated with a few probiotics that are human sourced: Mutaflor and SymbioFlor-2. It does not occur 100%. My memory (speculation) is that the samples were these studies were the same general ethnic base (Germany) as the source of these strains (in one case, we know it was a German Soldier fighting in the Great War – i.e. E.Coli Nissle 1917). For myself (and my wife), we both have significant German DNA — and they both work for us.

At this point, we hit the end of our current understanding.

The bottom line is simple:

  • If the strain does not come from a human, there is 0% chance of it taking up residency.
  • If the strain does come from a human, then the odds are better if some of your DNA comes from the same region as the source — and there is just one probiotic, Seed, that identify the source of their human-sourced strains. A Probiotic ahead of the rest of the market, as their label show below
    • US – likely a general blending of many DNA
    • IT – Italy
    • JP – Japan,
    • BE – Belgium,
    • SP – Spain
    • UK – United Kingdom
Another probiotic mixture that passes the bar…

Declaration of possible conflict of interests:
They do have a referral program, if you order via this link, I get free product (no cash).