Brain Fog – Hypoperfusion of the brain in ME/CFS and Long Covid

A reader followed a new article that seems to bear strong echoes from research done 23 years ago by David Berg at Hemex Labs. The article is “CFS/ME, FM: THERAPEUTIC TEST AND FIRST TREATMENT SCHEME FOR PATIENTS WITH CHRONIC FATIGUE AND BRAIN FOG TO ASSIST THE DIAGNOSIS OF PERSISTENT CLOTS AND HYPOPERFUSION.” Oct 2021

Our approach is that Chronic Fatigue Syndrome and Myalgic Encephalomyelitis (CFS/ME) include several Subgroups according to their pathophysiology and the causes that originate the symptoms, and most of the cases of CFS/ME correspond to a Subgroup in which there is an inadequate functioning of the blood vessels, more specifically a dysfunction of the endothelial cells, which in a high percentage is accompanied by a lower blood flow and a state of long-term hypercoagulability, with the presence of persistent clots that are attached to the vascular walls and also circulating intravascularly.
There are other Subgroups within CFS/ME, such as that associated with Dysbiosis, SIBO or alteration of the Intestinal Microbiota, a situation in which D-Lactate is increased.
There are also Subgroups associated with Vitamin depletion (especially B complex) and Subgroups associated with decreased hormones (especially thyroid and adrenal).
It should be taken into account that patients with CFS/ME can frequently present symptoms associated with several of the Subgroups of CFS/ME, being frequent that they present at the same time Endothelial Dysfunction, Dysbiosis or SIBO, and vitamin B complex depletion Endothelial dysfunction and persistent clots cause tissue hypoperfusion. Long-term dysfunction of the blood vessel walls and the presence of persistent clots causes a decrease in the perfusion of fluids from the bloodstream to the cells and tissues, which is called tissue hypoperfusion, which implies a lower contribution to cells and tissues of: – Oxygen (generating cellular hypoxia). – Vitamins. – Nutrients. – Hormones. – Other substances.
Long-term tissue hypoperfusion affects the normal functioning of organs and systems, especially those that require a greater supply of oxygen and nutrients, which are mainly the musculoskeletal system, the brain and the lungs.
Endothelial Dysfunction, Persistent Clots, and Hypoperfusion are not detectable with routine exams…
Gustavo Aguirre Chang Aurora Natividad Trujillo Figueredo

The study goes on to focus on elevated D-dimer as the critical test. Unfortunately, this is not as comprehensive as the Hemex panels being done in 1999 onwards by Hemex labs. Hemex lab specialized in coagulation issues, mainly issues with miscarriages caused by hypercoagulation, and stumbled on to the significance of hypercoagulation for ME/CFS. Hypercoagulation is a well established cause of hypoperfusion.

This article gives protocols etc. You may grab a copy here.

cfs-me-fm-therapeutictestandfirsttreatmentschemeforchronicfatigueandbrainfog.aguirre-changg Download

Some of my prior posts in this area are listed below:

Earthsong (Mary Redick) 2:33 am on February 2, 2022

Once again I must thank you with enormous gratitude. We are sure lucky to have you with your great dedication and intellect to match ….providing us with such valuable information. I am now almost regarding you as a saint or an angel. At the very least you are a beautiful being who is performing angelic functions! I am only sorry that you’ve had to suffer from this insidious, devastating, life altering, crippling disease. I keep thinking it’s happened to me to give me a new purpose in life…..to help inform folks about it (with what ever strength and energy I can muster). The only problem/challenge is I haven’t figured out how to do that yet. I so much respect you and those who are running websites, organizing groups and activities, writing articles, and otherwise carrying on this great and necessary work. For now, I’m mostly bedridden (recliner, to be precise), so all I’ve found to do so far is meditate/visualize/pray for us and for increasing knowledge of this disease. I’m definitely open to suggestions as to what else I could do to help! Ideas, anyone?
- lassesen 4:49 am on February 20, 2022
  
  My advance (especially for the brain fogged)
  1) Get an appropriate 16s stool test (see http://blog.microbiomeprescription.com/your-microbiome-is-unique-to-you/16s-microbiome-tests/top-microbiome-providers-with-discount-codes/)
  2) Upload the results to https://microbiomeprescription.com/
  3) Try the suggestions returned from the Artificial Intelligence program there…
  
  If they do not cause a positive change in a month, email me with what you tried, responses and the email you used to upload your sample and I will do a review….
Mary S Redick (known as “Earthsong) 10:46 pm on February 20, 2022

I’ll do it, by gosh! Next SSI Disability check.
Haley 1:29 am on March 25, 2022

Results from my MRIs
I don’t doubt a neurologist will say it’s normal even though I’m 23f with paralyzing fatigue

FINDINGS:

The spinal alignment is normal. Vertebral bodies are intact without compression
fracture. Bone marrow signal intensities are within normal limits.

The spinal cord demonstrates normal morphology and signal. No focal cord lesions
are noted.

At T7-8 there is a subtle disc space narrowing, dorsal annular fissuring
associated with a small left paracentral disc protrusion indenting the thecal
sac, contacting but not deforming or displacing the ventral cord resulting in no
central canal stenosis. The remaining intervertebral discs are well-hydrated
without bulging. The spinal canal and foramen are patent at each level without
stenosis or neural impingement.

The paravertebral soft tissues are unremarkable.

C2-C3: Slight disc desiccation. No disc herniation. No spinal canal or neural
foraminal stenosis.

C3-C4: Slight disc desiccation. No disc herniation. Mild uncovertebral
hypertrophy. No spinal canal or neural foraminal stenosis

C4-C5: Slight disc desiccation. No disc herniation. Mild uncovertebral
hypertrophy. No spinal canal or neural foraminal stenosis.

C5-C6: Relatively hydrated disc. No disc herniation. Mild left greater than
right uncovertebral hypertrophy with mild left neural foraminal narrowing. No
spinal canal or right neural foraminal narrowing.

C6-C7: Relatively hydrated disc. No disc herniation. Mild left greater than
right uncovertebral hypertrophy with mild left neural foraminal narrowing. No
spinal canal or right neural foraminal narrowing.

C7-T1: Relatively hydrated disc. No disc herniation. No spinal canal or
neuroforaminal stenosis.
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