A reader forwarded me a link to new probiotic that he is trying. Lactobacillus fermentum CECT5716 .  I post about Lactobacillus Fermentum ME3 – earlier

“Lactanza ^® hereditum ^® is a dietary supplement based on Lactobacillus fermentum Lc40 (CECT5716), a strain found naturally in breast milk. It is the first probiotic that contributes to the balance of the mammary flora.

The administration of Lactobacillus fermentum Lc40 (CECT5716) reduces the bacterial concentration of Staphylococcus in the mammary flora and helps to restore its balance, allowing a more comfortable and healthy lactation, and reducing the recurrence rate in mastitis ^31,32 . This helps to maintain lactation since mastitis is the main medical cause of premature and unwanted abandonment of breastfeeding ²³ .”

PubMed Literature

There are 20+ studies on this specific strain on PubMed ranking it as one of the most studies probiotic at the strain level.

• A synbiotic composed of Lactobacillus fermentum CECT5716 and FOS prevents the development of fatty acid liver and glycemic alterations in rats fed a high fructose diet associated with changes in the microbiota [2017].
• [Lactobacillus fermentum CECT5716 – probiotic from human milk with interesting properties] [2016].
• Lactobacillus fermentum CECT 5716 Reduces Staphylococcus Load in the Breastmilk of Lactating Mothers Suffering Breast Pain: A Randomized Controlled Trial. [2015]
• “Long-term administration of probiotics reduced systolic blood pressure.” [2015]
• The viability of Lactobacillus fermentum CECT5716 is not essential to exert intestinal anti-inflammatory properties [2015].
• Human milk probiotic Lactobacillus fermentum CECT5716 reduces the incidence of gastrointestinal and upper respiratory tract infections in infants [2012].
• Oral intake of Lactobacillus fermentum CECT5716 enhances the effects of influenza vaccination. [2007]
• Two Lactobacillus strains, isolated from breast milk, differently modulate the immune response [2007].
• “Therefore, in general, the effect of Lact. fermentum CECT5716 is immunostimulatory in contrast to the anti-inflammatory effect of Lact. salivarius CECT5713.” [2007]
• “Pretreatment with L. fermentum CECT 5716 attenuates trinitrobencene sulfonic acid  colitis, an effect that seems to be due to its antioxidant abilities. When administered after trinitrobencene sulfonic acid , this probiotic is also effective in accelerating colitis recovery, and this is associated with an enhanced Toll-like receptor function.” [2009]

• Lactobacillus plantarum CECT7315 and CECT7316 stimulate immunoglobulin production after influenza vaccination in elderly [2012]

Bottom Line

This is human sourced, like Lactobacillus Fermentum ME3 , and appear to have similar characteristics. It is well studies.

It is available on Amazon.co.uk , Amazon.es,, Amazon.it  but not US or Canadian sites.

Reader Summary

“I am a 56 year old female with a long history of illnesses followed by partial recovery for 5-7 years until the next thing hits me.  I was diagnosed with IBS and had multiple repeat infections in my teens (respiratory, bladder and yeast infections), mid 20’s I had a severe EBV infection (titers 10,240) and was hospitalized, followed by CFS with brain fog and severe fatigue causing me to spend 14 hrs a day in bed.  I recovered slowly over the next three years, but then in my late 30’s was diagnosed again, this time with Fibromyalgia with the primary issues being joint pain and hypersensitivity to many things.  I mostly recovered and was able to work normally, although I fatigued faster than most people and had to be very careful about what I ate and drank and ensure I rested as much as possible.  

In my late 40’s I started getting sick again, but my doc thought it was mostly related to hormone issues, so treated symptomatically until I had another bad respiratory infection which resulted in being diagnosed again with Fibromyalgia and CFS.  I’m on a multitude of treatments but still don’t have my life back yet almost 2 years later.  Symptoms include major sleep issues, pain, brain fog, and joint/body pain.  I have also been diagnosed with Hashimoto’s but have not noticed any difference with thyroid treatment.  “

Standard Items:

• Diversity: 2%ile
• Lactobacillus:  0.23x
• Bifidobacterium: 0.55x
• Akkermansia: 0x
• Firmicutes:Bacteroidetes: 0.4:1 (Normal  2.1:1)

Typical CFS profile

Uncommon Bacteria

Many many uncommon

• Anaerobacillus Genus 0.1%
• Ureaplasma Genus 0.8%
• Aerosphaera Genus 1.0%
• Jonquetella Genus 1.1%
• Mycoplasmataceae Family 1.3%
• Mycoplasmatales Order 1.3%
• Anaeroglobus Genus 1.4%
• Aerococcus Genus 1.6%
• Actinobaculum Genus 1.8%
• Ochrobactrum Genus 1.9%

High Bacteria

Reference

Several of the unusual overgrowths for CFS are associated with bacteria involved with the mouth which raises issues about oral health.

• Eisenbergiella: https://cfsremission.wordpress.com/2017/11/25/reducing-eisenbergiella-genus/
• Bacteroides: https://cfsremission.wordpress.com/2017/10/20/decreasing-bacteroides-genus/
• Subdoligranlum: https://cfsremission.wordpress.com/2017/10/10/decreasing-subdoligranlum/
• Odoribacter: https://cfsremission.wordpress.com/2017/10/19/decreasing-odoribacter-genus/
• Erysipelatoclostridium: https://cfsremission.wordpress.com/2017/11/14/decreasing-erysipelatoclostridium-genus/
• Catenibacterium: https://cfsremission.wordpress.com/2017/11/18/reducing-catenibacterium-genus/
• Dorea :  https://cfsremission.wordpress.com/2017/10/18/reducing-dorea-genus/
• Granulicatella: https://cfsremission.wordpress.com/2017/11/25/reducing-granulicatella-genus/
• Actinomyces: https://cfsremission.wordpress.com/2017/11/25/reducing-actinomyces-genus/

Bottom Line Suggestions

The lists below are done by merging the lists from the deep dives linked above. Some items may encourage one genus and discourage another genus — those are removed (unless it seems that it strongly predominates on one). The impact on Lactobacillus, Bifidobacterium and E.Coli are intentionally ignored [See this post for the logic]. This is all based on applying logic to the results of studies — thus theoretical. This is an addition (not a replacement) to this overview post.

Avoid

• Allergens
• Animal-based diet
• Bacillus subtilis
• Barley
• Berberine
• Bifidobacterim Breve
• Bifidobacterium animalis subsp. lactis
• Bifidobacterium catenulatum
• Bifidobacterium pseudocatenulatum
• BIO-THREE
• Broad beans  and lupin seeds
• Dairy
• Enterococcus faecium
• fermented Korean soybean paste
• Fructo-oligosaccharides
• Gallic acid
• gum arabic
• Helminth infections
• High meat diet
• Isoniazid-
• Italian-style gluten-free diet
• Lactobacillus acidophilus
• Lactobacillus rhamnosus
• Lactobacillus salivarius
• Lactobacillusplantarum
• lacto-ovo-vegetarian diet
• L-citrulline
• Low fat diets
• Macrolides
• Navy bean (Cooked)
• Omega 3
• Partial Sleep Deprivation [parent]
• pomegranate juice
• Proton-pump inhibitors (PPI)
• Pyrazinamide
• Red wine, Grape Seed Extract
• Resistant starch (type IV)
• Rifampin-
• Saccharin
• Saccharomyces boulardii
• Sleepless nights
• Stevia
• stress
• Stress
• Sucrose (ordinary sugar)
• Tannic acid
• Walnuts (and likely pomegranates)

Take

• Bacillus licheniformis
• Bifidobacterium longum
• Flaxseed
• Galactooligosaccharides
• Garlic
• Good Dental Health
• Inulin
• Ketogenic diet
• Lactobacillus fermentum
• Lactobacillus gasseri
• Lactobacillus rhamnosus
• Lactobacillus kefiri LKF01
• l-glutamine
• Maltitol
• Oats
• Oligosaccharide prebiotics
• Oral Iron Supplements
• Polymannuronic acid
• Sucralose (Splenda)
• Vegetable/fruit juice-based diets
• Whole Grains
• β-Glucan

Personal Note

This is an outlier to the usual CFS Microbiome:

• Diversity at 2% (versus 98% often seen)
• Bifidobcaterium is not low, just low average
• Lactobacillus is not low, just low average

That there is a microbiome dysfunction is clear! The microbiome just does not match the usual pattern seen with CFS.

• Extremely low diversity — to improve, I would suggest these
  • Prescript Assist
  • Equilibrium
• No apparent need to recommend bifidobacterium
• The four above Lactobacillus should be beneficial
• Flaxseed with Oats and other whole grain for breakfast with fruit using Sucralose for sweetening may be a good diet change

This is an education post to facilitate discussing this approach with your medical professionals. It is not medical advice for the treatment of CFS. Always consult with your medical professional before doing any  changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.

For updated information see Microbiome Prescription

The mouth appears to the most common source of this genus.

DataPunk.Net Data

Nothing

PubMed Data

There are 7300+ articles on PubMed

Disease

• Infections:
  • Neonatal sepsis secondary to chorioamnionitis by Actinomyces neuii in a 25 weeks pregnant woman.[2017]
  • Breast abscess due to Actinomyces turicensis in a non-puerperal woman.[2017]
  • Primary Abdominal Wall Abscess by Actinomyces and Eikenella corrodens: A First Report. [2017]
• ” Furthermore, in the diabetes mellitus group, Actinomyces and Selenomonas showed significantly higher abundance, whereas Alloprevotella showed significantly lower abundance, relative to the non-diabetes mellitus group. ” [2017]
• Actinomyces: a deceptive infection of oral cavity. [2017]

Diet

• “Actinomyces HOT-169 were significantly reduced following use of maltitol chewing gum in patients. ”  [2017]
• “The numbers of Bifidobacterium, Actinomyces, and Enterobacteriaceae species, as well as S-forms of E. coli were significantly increased in the Salem[lacto-ovo-vegetarian diet]-group, as compared to the school-children.” [1983]

Prebiotics

Probiotics

•  ‘”In group EP-HN019 (with Bifidobacterium animalis subsp. lactis ), there were greater proportions of Actinomyces and Streptococcus-like species and lower proportions of Veillonella parvula, Capnocytophaga sputigena, Eikenella corrodens, and Prevotella intermedia-like species than group EP. ” [2017]
• Antimicrobial Effect of Lactobacillus reuteri on Cariogenic Bacteria Streptococcus gordonii, Streptococcus mutans, and Periodontal Diseases Actinomyces naeslundii and Tannerella forsythia [2015].
• “the count of cecal Actinomyces in birds treated with [B. subtilis and L. acidophilus ] probiotics was significantly lower compared with the control group. ” [2014]
• “Lactobacillus gasseri. All the tested strains inhibited S. mutans and A. viscosus; only one did not inhibited F. nucleatum and 52 strains inhibited slightly the growth of P. gingivalis. ” [2013]
• “Only a few strains inhibited Actinomyces pyogenes 96/393,… Most of the strains were identified as Lactobacillus fermentum, a few as Lactobacillus gasseri and one as Lactobacillus rhamnosus.” [2006]
• “Periodontal dressing consisting of collagen and Lactobacillus casei 37 cell suspension (cell concentration 108 cells/ml) was created and used in combined treatment of patients with chronic generalized parodontitis. Efficacy of the developed isolation was explained by a considerable decrease of the number and frequency of isolation of aggressive microbial representatives (pigment synthesizing Bacteroids, Actinomycesand Str. intermedius) in periodontal pockets and also Fungus (Candida albicans). This periodontal dressing provided remission up to 10-12 months.” [2004]
• Sugar increases vs whole grains and oats decreases [1992]

Antibiotics

Bottom Line

Avoid

• Bifidobacterium animalis subsp. lactis
• Sucrose (ordinary sugar)
• lacto-ovo-vegetarian diet

Take

• Lactobacillus gasseri
• Lactobacillus reuteri
• Lactobacillus rhamnosus
• Lactobacillus fermentum
• Lactobacillus casei
• Maltitol
• Oats
• Whole Grains

For updated information see Microbiome Prescription

The mouth appears to the most common source of this genus.

DataPunk.Net Data

INHIBITED BY

• Walnuts [parent]

ENHANCED BY

• Proton-pump inhibitors (PPI)

ANTIBIOTIC RESISTANCE

• Macrolide

PubMed Data

There are 170+ articles on PubMed

Disease

• Infections:
  • Lumbar Spine Infection by Granulicatella and Abiotrophia Species [2017].
  • First Report of Granulicatella sp. Endocarditis in a Kidney Transplant Patient[2017].
  • First case of prosthetic knee infection with <i>Granulicatella adiacens</i> in the United States. [2017]
  • Granulicatella adiacens prosthetic hip joint infection after dental treatment[2016].\
• “Poor dentition and/or dental infection due to insufficient oral care are presumed to be risk factors for infective endocarditis (IE). We present a case of endocarditis caused by Granulicatella adiacens and Sjögren’s syndrome (SS) with oral complications diagnosed simultaneously. ” [2016]
• ” those influencing the absence of caries belonged to the Actinomyces, Bergeyella, Campylobacter, Granulicatella, Kingella, Leptotrichia, and Streptococcus genera.” [2015]
• “presence of Aggregatibacter actinomycetemcomitans (OR 29.4 [3.4-176.5]), Cardiobacterium hominis (OR 14.9 [2.3-98.7]), Peptostreptococcaceae sp. (OR 35.9 [2.7-483.9]), P. alactolyticus (OR 31.3 [2.1-477.2]), and absence of Fretibacterium spp. (OR 0.024 [0.002-0.357]), Fusobacterium naviforme/Fusobacterium nucleatum ss vincentii (OR 0.015 [0.001-0.223]), Granulicatellaadiacens/Granulicatella elegans (OR 0.013 [0.001-0.233], p < 0.05) were associated with aggressive periodontitis.” [2014]

Diet

• “An Italian-style gluten-free diet caused increases in the abundance of Granulicatella, Porphyromonas and Neisseria and decreases in Clostridium, Prevotella and Veillonella, altering the ‘salivary type’ of the individuals.” [2015]

Prebiotics

Probiotics

•  L. reuteri intake correlated with increased S. oralis/S. mitis/S. mitis bv2/S. infantis group and Campylobacter concisus, Granulicatella adiacens, Bergeyella sp. HOT322, Neisseria subflava, and SR1 [G-1] sp. HOT874 detection and reduced S. mutans, S. anginosus, N. mucosa, Fusobacterium periodicum, F. nucleatum ss vincentii, and Prevotella maculosa detection.  [2015]

Antibiotics

• ” All isolates were susceptible to vancomycin and >90% were susceptible to levofloxacin.” [2017] [2016]
• “62% of G. adiacens isolates were ceftriaxone nonsusceptible.” [2016]

Bottom Line

Avoid

• Lactobacillus Reuteri
• Proton-pump inhibitors (PPI)
• Macrolides
• Italian-style gluten-free diet

Take

• Good Dental Health
• Walnuts

For updated information see Microbiome Prescription

DataPunk.Net Data

INHIBITED BY

• Flaxseed [parent]

ENHANCED BY

• Walnuts [parent]
• Saccharomyces boulardii [parent]

PubMed Data

There are 4+ articles on PubMed.

• “The isolate produced butyrate, lactate, acetate and succinate as major metabolic end products. ” [2014]

Diet

• “On the other hand, proportions of the following bacterial genera were decreased significantly at day 4 of a [Vegetable/fruit juice-based diets] compared to baseline (percent of baseline): Streptococcus (8%), Subdoligranulum (30%), Eisenbergiella (40%), Ruminiclostridium (50%), and Dialister (67%)” [2017]

Bottom Line

Avoid

• Walnuts
• Saccharomyces boulardii

Take

• Flaxseed 
• Vegetable/fruit juice-based diets