Category Archives: Conditions

Unknown's avatar lassesen 11:04 pm on November 11, 2017  

Decreasing Anaeroplasma Genus

For updated information see Microbiome Prescription

This is often classed as a mycoplasma [A Phylogenetic Analysis of the Mycoplasmas: Basis for Their Classification, 1989]. CFS aas a mycoplasma infection has been one CFS research direction in the past.

“There are six genera of wall-less prokaryotes collectively referred to in this article as
mycoplasmas. These genera are Mycoplasma, Acholeplas ma, Spiroplasma, Ureaplasma,
Anaeroplasma, and the newly recognized genus Asteroleplasma. ” [1990]

DataPunk.Net Data

Tenericutes -> Mollicutes -> Anaeroplasmatales -> Anaeroplasmataceae -> Anaeroplasma

Nothing

PubMed Data

There are  30+ studies on pubmed

Disease

  • “Eubacteria, Anaeroplasma, Roseburia, Oscillospira and Dehalobacteria appeared to be protective against atherosclerosis and showed significant negative correlation with atherosclerotic plaque size and plasma adipocyte – fatty acid binding protein (A-FABP) and cholesterol.” [2016]
  • “The abundance of Pedobacter, Anaeroplasma, Paludibacter, Ruminococcus, and unclassified Lachnospiraceae was positively correlated with the CH4(methane) production, with no effects on volatile fatty acids.” [2016]

Diet

  • ” Inclusion of higher-Molecular Weight Condensed tannin  fractions F1 and/or F2 decreased the relative abundance of minor genera such as Ruminococcus, Streptococcus, Clostridium XIVa and Anaeroplasma but increased the relative abundance of Acinetobacter, Treponema, Selenomonas, Succiniclasticum “

Prebiotics

Probiotics

Antibiotics

  • Tetracyclnes, Sparfloxaccin are the most effective against the mycoplasma family [1997]
  • “neomycin-treated mice was depleted in several microbes that were increased with vancomycin treatment; Enterobacteriaceae, Anaeroplasma spp. and Sutterella spp.”  [2016]
  • “On the contrary, Anaeroplasma was the most reduced genus of all detectable genera, as its relative abundance decreased by 43% after streptomycin treatment.” [2017]

Bottom Line

Avoid

  • Vancomycin

Take

  • Tetracyclnes, Sparfloxaccin, Neomycin, Streptomycin
  • Tannins
  • Walnuts (Weak Evidence, we have to go up to Millicutes Class to find this)
Unknown's avatar lassesen 5:59 pm on November 11, 2017  

Decreasing Victivallis Genus

For updated information see Microbiome Prescription

DataPunk.Net Data

Lentisphaerae -> Lentisphaeria -> Victivallales -> Victivallaceae -> Victivallis

Nothing

PubMed Data

There are  7+ studies on pubmed

Disease

  • Associated with genital-tract disease in cattle. [2015]

Diet

  • “In pure culture, strain CelloT could only grow on a variety of sugars. Glucose was converted to acetate, ethanol and H2. ” [2003]

Prebiotics

Probiotics

Antibiotics

  • common antibiotics appear to increase it [2012]
  • ” The antibiotics streptomycin and polymyxin B may be used to inhibit growth of contaminants.”[Bergey’s manual of Systematic Bacteriology, Volume 4]  i.e. This genus is resistant to these antibiotics.

Bottom Line

Note: This bacteria is hard to culture, which means testing of antibiotics to find an effective one very challenging.

Avoid

  • Streptomycin
  • Polymyxin B

Take

Unknown's avatar lassesen 6:23 am on November 11, 2017  

Ubiome for a reader in Spain

Standard Measures

All of the standard shifts seen with CFS

Rare Bacteria Genus

Just one < 5%. This has little information and it is a sibling to Aldercreutzia

Bacteria name Rank % of Samples
Paraeggerthella Genus 0.5%

Over grown Bacteria Genus

Bacteria
Ratio
Parasutterella:  13.92 X
Adlercreutzia:  6.84 X
Bilophila:  6.36 X
Butyricimonas: 5.28 X
Oscillibacter: 3.69 X
Intestinimonas: 3.36 X
Odoribacter: 3.20 X
Flavonifractor: 3.10 X
Alistipes:  3.03 X
Moryella: 2.04 X
Bacteroides:  1.77 X
Dorea: 1.72 X
Dialister: 1.55 X

References to literature that I am working off:

I have highlighted the extreme overgrowth associated suggestions in red

Bottom Line Suggestions

The lists below are done by merging the lists from the deep dives linked above. Some items may encourage one genus and discourage another genus — those are removed (unless it seems that it strongly predominates on one). The impact on Lactobacillus, Bifidobacterium and E.Coli are intentionally ignored [See this post for the logic]. This is all based on applying logic to the results of studies — thus theoretical. This is an addition (not a replacement) to this overview post.

Avoid

Bold — applies to HIGHEST, Italic to lowest

  • Allergens
  • Animal-based diet
  • Bacillus probiotics
  • Barley
  • Berbine
  • Bifidobacterium Animalis subsp. Lactis BB-12
  • Bifidobacterium catenulatum
  • Bifidobacterium longum.
  • Bifidobacterium pseudocatenulatum
  • Bile
  • Broad beans  and lupin seeds
  • Clostridium butyricum
  • Fermented Korean soybean paste
  • Fish Oil
  • Fructo-oligosaccharides
  • Gallic acid
  • Gum arabic
  • Helminth infections
  • High animal protein/meat diet
  • High Fat Diet
  • High meat diet
  • Lactobacillus fermentum
  • Lactobacillus Reuteri
  • L-citrulline
  • Low fat diets
  • Lysine supplements and foods
  • Metformin
  • Milk-derived saturated fat
  • pomegranate juice
  • Proton-pump inhibitors (PPI)
  • Saccharin
  • Saccharomyces boulardii
  • Stevia
  • stress
  • Tannic acid
  • Walnuts (and likely pomegranates)

Take

Bold — applies to HIGHEST, Italic to lowest

  • Bifidobacterum Bifidum
  • Bifidobacterum Infantis
  • Cellobiose
  • Chicory
  • Cranberry bean flour (or fresh cranberries)
  • E.Coli Probioitics
  • Enzymatically modified resistant starch
  • Faecalibacterium prausnitzii
  • Flaxseed
  • Galactooligosaccharides 
  • Gallate – green tea
  • Garlic
  • Grapes (table) – Resveratrol (grape seed extract)
  • Inulin
  • Lactobacillus Casei
  • Lactobacillus kefiri
  • Lactobacillus plantarum
  • Lactobacillus rhamnosus GG
  • Lactobacillus salivarius 
  • L-glutamine
  • Oligosaccharide prebiotics
  • Oral Iron Supplements
  • Polymannuronic acid
  • Resistant starch (type II & IV)
  • Sucralose (Splenda)
  • Vitamin D3
  • β-Glucan

This is an education post to facilitate discussing this approach with your medical professionals. It is not medical advice for the treatment of CFS. Always consult with your medical professional before doing any  changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.

Unknown's avatar lassesen 5:48 am on November 11, 2017  

Decreasing Moryella genus

For updated information see Microbiome Prescription

DataPunk.Net Data

INHIBITED BY

ENHANCED BY

PubMed Data

There are 9+ studies on PubMed.

Disease

  • “Aggregatibacter (OTU id 4363066), Haemophilus, Haemophilus parainfluenza (H. parainfluenza), Moryella, Oribacterium, Prevotella, several Streptococcus, Rothia dentocariosa .. were reduced with Intra-oral halitosis] [2017]
  • “Decreased carriage of genera Lautropia, Bulleidia, Catonella, Corynebacterium, Moryella, Peptococcus and Cardiobacterium were found in  esophageal squamous cell carcinoma  subjects” [2015]
  • “The less represented genera Mogibacterium, Moryella and Oribacterium were enriched statistically in the tuberculosis samples,” [2013]

Diet

  • ” resveratrol ingestion produces taxonomic and predicted functional changes in the gut microbiome of obese mice. In particular, changes in the gut microbiome were characterized by a decreased relative abundance of Turicibacteraceae, Moryella, Lachnospiraceae, and Akkermansia and an increased relative abundance of Bacteroides and Parabacteroides ” [2017]
  • “Wheat… was strongly associated with the abundance of Firmicutes lineages such as Clostridium, Ruminococcus, Oscillospira and Moryella” [2014]

Prebiotics

Probiotics

Antibiotics

Bottom Line

Avoid

Take

  • Resveratrol (grape seed extract)
  • Flaxseed
Unknown's avatar lassesen 4:20 am on November 9, 2017  

Cat’s Claw and the CFSer

A reader pointed out that I have not mentioned this in any of the 800 posts to date. It is a good question!

My process is always to go to sources not dependent on one individual’s experience

Common Names:  cat’s claw, uña de gato,  پنجه  گربه in Persian, and مخلب  القط  in Arabic.

Latin Name:  Uncaria tomentosa (usual in commercial products), Uncaria guianensis
“There’s no conclusive scientific evidence based on studies in people that supports using cat’s claw for any health purpose.” Nation Center for Complementary and Integrative Health

PubMed and Google Scholar

  • On PubMed
    • “Uncaria tomentosa microbiome” – Zero hits
    • Uncaria tomentosa  – 204 hits
      • “Although there are no randomized controlled trials or published human outcome studies, some conditions reportedly improved by U. tomentosa include osteoarthritis, rheumatoid arthritis, prostatitis, viral illnesses and cancer (acting as a non-specific immunomodulantign agent) ” [2017]
    • “Uncaria tomentosa bacteria” – 16 hits
      • “antibacterial effect of 2% CC gel against E. faecalis in infected dentin” [2016]
      • “U tomentoa gel had the same effect as 2% miconazole gel. U tomentosa gel is an effective topical adjuvant treatment for denture stomatitis.” [2014]
      • “2% chlorhexidine (CHX) +cat’s claw (CC)  against the tested microbial strains ranged from 21.7 to 33.5 mm. This was the most effective substance against E. faecalis and C. albicans, followed by CHX and CC. Against S. aureus, CHX+CC, CHX, and CC showed similar antimicrobial activity (P > 0.05). ” [2010 ] CC was the least effective of the combinations tested.
      • “Three percent Uncaria tomentosa inhibited 8% of Enterobacteriaceae isolates, 52% of Streptococcus mutans and 96% of Staphylococcus spp. ” [2007]
      • “Nine ethanol extracts of Brunfelsia grandiflora (Solanaceae), Caesalpinia spinosa (Caesalpiniaceae), Dracontium loretense (Araceae), Equisetum giganteum (Equisetaceae), Maytenus macrocarpa (Celastraceae), Phyllanthus amarus (Euphorbiaceae), Piper aduncum (Piperaceae), Terminalia catappa (Combretaceae), and Uncaria tomentosa (Rubiaceae), medicinal plants traditionally used in Calleria District for treating conditions likely to be associated with microorganisms, were screened for antimicrobial activity against nine bacterial strains using the broth microdilution method.”  [2005] Uncaria tomentosa was among the least effective.
    • From Google Scholar
      • “This small preliminary study demonstrates relative safety and modest benefit to the tender joint count of a highly purified extract from the pentacyclic chemotype of UT in patients with active RA taking sulfasalazine or hydroxychloroquine.” [2002]

Bottom Line

Cat’s claw is a poor financial choice. While it shows some benefits for dental issues, despite it’s long usage — there is a very significant absence of human studies showing significant benefit when taken alone.  It appears to have “modest” benefit when used with antibiotics.

This [2016] articles cites all of the reasonable studies. There is no evidence supporting it’s use in CFS, FM or IBS. The absence of published studies for a common recommendation in alternative medicine hints that there may have been studies with no positive results.