Next generation probiotics in disease amelioration, 2019 indicates that we may see the following in the next years.

• Prevotella copri 
• Christensenella minuta
• Parabacteroides goldsteinii, 
• Akkermansia muciniphila
  • could be available on the market by the end of 2021 through the Belgian spinoff company “A-Mansia Biotech<https://www.a-mansia.com/>”.
• Bacteroides thetaiotaomicron
• Faecalibacterium prausnitzii
• Bacteroides fragilis 
• Eubacterium hallii  [2019]
• Ruminococcus bromii [2019]

Where and when they will be available may get complex. None of these would be grandfathered with the FDA, thus they will be required to produce the same type of evidence that is required for a new living vaccine before they may be sold in the US. Mutaflor, E.Coli Nissle 1917 has been used in Europe for over 100 years and sold over the counter, but cannot be sold in the US because of FDA regulations requiring a massive amount of US based testing to prove that it is safe.

Some may only be available by prescription in some countries.

Mutaflor is sold OTC in Canada and Australia which did not require those loops to be jumped thru.

NOTE: Probiotics for pets (Veterinary) do not require such review — Fido may get them before you do!

Hydrogen Sulfide levels are often used to diagnosis SIBO. (Hydrogen sulphide in exhaled breath: a potential biomarker for small intestinal bacterial overgrowth in IBS. 2016) Today I saw a naive comment and would like to educate SIBO folks on what is known from actual studies.

“Hydrogen sulfide producing bacteria are gram negative proteobacteria.

A post on Facebook

Who produces hydrogen sulfide?

• Fusobacterium from cysteine [2019]
• Fusobacterium nucleatum  [2018]
• Desulfosporosinus orientis (gram POSITIVE) and Desulfovibrio desulfuricans [2018]
• Low pH [2018]
• Saccharomyces cerevisiae [2017] aka saccharomyces boulardii
• Bilophila wadsworthia from taurine [2017]
• Mycoplasma pneumoniae [2016]
• Veillonella  from cysteine, Veillonella dispar, Veillonella parvula [2014]
• Tissierella from peptone, Desulfosporosinus  [2013]
• Desulfovibrio piger, Lactate has the potential to promote hydrogen sulphide formation in the human colon.[2009]
• Veillonella, Actinomyces , Prevotella [2005]

Positive findings:

• Enterococcus faecium strain L86 reduced it [2011]

This post list where people may order single strain probiotics. It is an copy and paste from http://microbiomeprescription.com/library/Probiotics

The above link will be expanded and updated, so go there for the latest information.

A reader left me a voice mail and sounded very frustrated trying to deal with dry mouth. Fortunately it is a symptom in our Eureka database. The apparent cause is excessively low amounts the following genus:

• Faecalibacterium x 163
• Dorea x 81
• Roseburia x 72
• Blautia x 29
• Lachnospira x 9

And possible high amounts of:

• Akkermansia x 4
• Intestinimonas x 11

Since this is at the genus level, we do have an ability to look for suggestions for this combination explicitly by going to: Enter All Bacteria [Genus] Reported Report and enter the values. You could examine your own levels and modify what is entered there to better match.

With the following on the avoid/stop list

New Page is Up

The logic behind the web site is similar to the logic used for Will this supplement help my symptom? and will be be a new page under

It will only list the genus and species level with a strong association. Just click the desired symptoms (some may have no result)

This will take you to the key elements. The higher the number, the more probable.

Remember this is an association. It may be the cause — or it may be a side effect of the symptom. We do not know.

Often choice of supplements to try is based on hearsay. Hearsay can often be seeded by people with vested interests in selling a product. A seasoned medical professional may notice patterns and advocate on those — but those are often bias by placebo effects.

For people that have done 16s microbiome analysis, uploaded them and annotated them with symptoms — we can generate a list of supplements suggestions that matches both microbiome and symptoms — sweet. See this post for an example.

Today, in answering some correspondence, I realized that using the same Eureka data, we can provide hints on what a supplement is likely to help. Hints based solely on statistics. It has now been implemented on the site.

Click on Changing your Microbiome

Then the appropriate group, and then a specific item

You will see a new section (sometimes — if there is data). For an example, I looked at Holigos (available on Amazon), and we see up to 10 symptoms that it may impact.

Does it work? I went thru the full list of Eureka symptoms and found that its studies and the predicted impact were reasonable matches (for what they had studied).

Bottom Line

If someone suggests that you should try ‘snake oil’ for speaking in tongues, then look up ‘snake oil’ and see if there is some evidence that it could help. If not, consider saving your money.

Note: As more people contribute 16s microbiomes (ubiome is typical) AND annotated them with symptoms, the more accurate and detail that this will become!