Why Jadin’s Antibiotics Protocol usually work — Pasteur Institute got the solution right and the explanation wrong?

My second onset of CFS was resolved by following Dr. Celile Jadin. The decision to do a combo Hemex-Jadin protocol was that neither were in conflict with each other — in fact, at the start, they appear to compliment each other. For example bromelain breaks down coagulation and it also allows deeper penetration of antibiotics into tissues.

The Jadin protocol originated with Pasteur Institute staff in Africa dealing with difficult illnesses. I suspect that by trial and error they found a protocol that address the stubborn illness they were trying to treat. As is human nature, they wanted to know why and once a reasonable explanation was found, that became the explanation of what was happening. I know from the history of science that explanations are often wrong, but the observations and many predictions are right.

My best hypothesis on CFS is currently a stable dysfunctional microbiota (gut flora) that was triggered by an illness, poor diet, vaccination or chemical exposure.  It is good to put this hypothesis to the test against prior successful treatments that resulted in some remissions. I have already looked at this in an earlier post, but thought a revisit on certain aspects would be good.

Jadin and Occult Infections

Cecile Jadin, M.D., has had great success with an antibiotic rotation that the Pasteur Institute had used 70 years ago to deal with what they felt were occult infections[Presentation].  In reflection, I can very well see how they came to that conclusion.  If the symptoms of an infection that was successfully treated returned but cannot be detected then a reasonable assumption was that it was somehow “occult” or hidden.  If you shift your perspective to the symptoms not being caused directly by the infection but by the alteration in the gut bacteria that the infection caused then it is not the infection returning in a hidden form — it is the gut bacteria alteration becoming stable in the “disease pattern”. Without modern research testing facilities, it is impossible to differeniate them.

What does going through multiple families of antibiotics do to gut bacteria?  Kill many of them. Many people will not take antibiotics because they kill gut bacteria — not all gut bacteria, just some species. Her regime of rotating antibiotics is a perfect way of disrupting this stable bacteria alteration.

  • I constructed the table below ‘unscientifically’ by just googling the antibiotic family and the bacteria family and seeing what the usual result was. The impact of the families of antibiotic appears  to be a good match for what we want to have happen. Jadin’s protocol was based on experimentation on people with the appearance of occult illness due to Rickettsia. They did not have the labs we have. They found traces of Rickettsia in the tissue and went down a logical path that said “Oh we have a resistant version — we need to try other antibiotics!” This was exactly the logic that my MD used for my first onset of CFS (before it was a known condition).
Antibiotic FamilyKlebsiella/EnterobacterEnterococcusStreptococcusE.ColiBifidobacteriumLactobacillusScore for CFS
In CFS PatientsHIGHHIGHHIGHlowlowlow*

Other Antibiotics (by request). Score done by 1 for each EFFECTIVE in high (good) and -2 for each EFFECTIVE in low (I view the harm is more significant than the good)

Antibiotic FamilyKlebsiella/EnterobacterEnterococcusStreptococcusE.ColiBifidobacteriumLactobacillusScore for CFS
In CFS PatientsHIGHHIGHHIGHlowlowlow*
AmoxycillinResistant [*]Effective[*]EffectiveResistantEffective[*]Effective[*]-2
Lactobacillus probiotics (General)Resistant [2014]Resistant [2014]EffectiveEffectiveEffective-3

What is seen is that the probable over growths are reduced with this protocol as reported in the 1998 Conference Presentation, and most of the under growths are not impacted. Similar results were reported for two species: “The viable count of D-lactic acid producing Enterococcus and Streptococcus spp. in the faecal samples from the CFS group.. were significantly higher than those for the control group ” Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome. [2009]

In short, Jadin’s effective protocol is in agreement with the microbiota model.  It is a viable protocol to use in conjunction with probiotics – just don’t use Mutaflor (E.Coli Nissle 1917) with Metronidazole, or L.Reuteri with Quinolones.