Case Study on Using DNA: Multiple Chemical Sensitivity

One of the panels available on    deals with Multiple Chemical Sensistivy. One of my readers shared their profile and asked for suggestions on where to go from that. This shows how I would proceed. In this case the issue was simple and I could find suggestions.

First the results — we have two REDs

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We are actually lucky because both REDS are on the same mutation (but different SNPs): GSTP1

Click the link we get the usual type of information which lacks any information about treatment.

NCBI Gene Info

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]

The next step is simple, take the gene mutation and google it with “treatment” and then “supplements” and see what you can find.

The first item to be aware of is to ignore the condition they are dealing with – if it is prostate cancer and you are a woman, you would normally stop reading.. WRONG… we are interested in compensating for the SNP/Gene/Mutation and not for a specific diagnosis. Some of the items I found are:

Some health professionals recommend individuals with GSTP1 SNP’s minimize their exposure to cigarette smoke, charred food, herbicides, fungicides, insect sprays, industrial solvents, and toxic metals. In addition to ensure GSH support it is important to supply GSH precursors and cofactor such as, methionine, NAC, glutamine, glycine, magnesium, and pyridoxal-5-phosphate (B6). It is possible to reduce GSH depletion by supplementing with alpha lipoic acid, milk thistle, and taurine.   Certain foods such as onions, leeks, garlic, broccoli, cauliflower, cabbage, kale, Brussels sprouts, and radish can increase GST activity.   It is always recommended to consume an antioxidant-rich diet to prevent oxidative stress..[link]

What! We have a supplement list provided. Checking carefully to the source and it was a forum — which is not my preferred information source. So while noting the above, I will move all to published studies….

PubMed Articles on Supplements and GSTP1

I found some 1250 articles on GSTP1 and grabbed two of the more well documented supplements.

High cruciferous vegetable (cauliflower, cabbage, garden cress, bok choy, broccoli, brussels sprouts) intake reduced the impact[book – 2008 Study]

Alpha Lipoic Acid