lassesen 4:55 pm on October 14, 2017  

Decreasing Prevotella genus

I did an earlier post on a member of this genus which was reported high in most CFS patients by Ian Lipkin et al 2017 study .  In this post we can add probiotics to the list of controlling substances instead of just antibiotics.

For updated information see Microbiome Prescription

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PubMed Data

There are 4700+  studies on PubMed. A lot of these are associated with oral/dental health.

  • Disease:
    • Population-Genomic Insights into Variation in Prevotella intermedia and Prevotellanigrescens Isolates and Its Association with Periodontal Disease. [2017]
    • “Dysbiosis, consisting of enrichment in some Gram-negative taxa (including Veillonella, Prevotella, Haemophilus, Neisseria, Campylobacter, and Fusobacterium), has been reported in association with gastroesophageal reflux disease” [2016]
    • “the study found Veillonella(19%), Prevotella (12%), Neisseria (4%), and Fusobacterium (9%) to be more prevalent in patients with reflux esophagitis and Barrett’s esophagus than in controls.” [2014]
    • “Consistent with the literature linking psychiatric disorders with dysbiosis is that life adversity during childhood and certain temperaments that develop early in life are associated with altered gut microbiota, particularly the Prevotella species. ” [2017]
    • “The P. copri and B. vulgatus species were associated with insulin resistance in previous studies.” [2017]
    • “Subjects with improper levels of total cholesterol were enriched in Prevotella” [2017]
    • ” Women (N = 40) with incident bacterial vaginosis (Nugent 7-10) had significantly lower concentrations of lactobacilli and higher concentrations of Gardnerella vaginalis, Atopobium vaginae, and Prevotella bivia, at the incident visit ” [2017]
    • “We observed the declined abundance of Prevotella_9 and Dialister in Hypothyroid Hashimoto’s thyroiditis , while elevated genera of the diseased group included Escherichia-Shigella and Parasutterella.” [2017]
    • ” genus Prevotella was under-represented in enthesitis-related arthritis patients. ” [2017]
    • “A significant inverse correlation was found between the abundance of Prevotella and the severity of postprandial distress-like symptoms in patients with functional dyspepsia” [2016] – High prevotella means less severe.
    • “A growing number of microbiota constituents such as Prevotella copri, Porphyromonas gingivalis, and Collinsella have been correlated or causally related to rheumatic disease. [2016]
    • Intestinal Dysbiosis and Rheumatoid Arthritis: A Link between Gut Microbiota and the Pathogenesis of Rheumatoid Arthritis [2017].
      • “a marked increase of species belonging to the genus Prevotella”
  • Diet:
    • “niacin had a trend to decrease the percentage of Prevotella, and to increase the abundance of Succiniclasticum, Acetivibrio and Treponema. “
    • Antimicrobial Effects of Mastic Extract Against Oral and Periodontal Pathogens[2017].
      • Mastic extract led to significantly (P ≤0.016) increased inhibition of the tested periodontal pathogens((Porphyromonas gingivalis,  Streptococcus oralis, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Prevotella intermedia, and Prevotella nigrescens) ) compared with H2O2(Hydrogen Peroxide). No effect of mastic extract was observed on Streptococcus mutans”.
    • “Dietary advanced glycation end products restriction altered the bacterial gut microbiota with a significant reduction in Prevotella copri and Bifidobacterium animalis relative abundance” [2017]
    • Sialic Acid (R, R2) (higher levels found in red meat and milk)
      • A relative rise in Prevotella
    • “Rosemary Extract …increased the Blautia coccoides and Bacteroides/Prevotella groups and reduced the Lactobacillus/Leuconostoc/Pediococccus group in both types of animals.” [2014]
    • “cooked navy bean (NB) or black bean (BB) similarly altered the fecal microbiota community structure (16S rRNA sequencing) notably by increasing the abundance of carbohydrate fermenting bacteria such as Prevotella, ” [2017] — NOTE: DataPunk states opposite.
    • “Higher relative abundance of Streptococcus sobrinus and Prevotella melaninogenica was observed in plaque samples in the reference group [lower sugar intake]. ” [2017]
    • “At the genus level, strict vegetarians had a higher Prevotella abundance and Prevotella/Bacteroides ratio than the other groups.” [2017]
    • ” However, lipopolysaccharides increased with the reduction of 25(OH)D (p-trend <0.05). Prevotella was more abundant ” [2017]
      • ” Lower level of vitamin D resulted in reduced vitamin D receptor and increased expression of pro-inflammatory genes in the colon at 3 months, lower numbers of colonic Bacteroides/Prevotella ” [2014]
    • “antimicrobial effect observed for the grape seed polyphenols, particularly against Bacteroides, Prevotella and Blautia coccoides-Eubacterium rectale.” [2015]
    • Consumption of different soymilk formulations differentially affects the gut microbiomes of overweight and obese men [2012].
      • low glycinin soymilk (LGS)
        • Bacteroides-Prevotella and Lactobacillus increased
      • conventional soymilk (S)
        • No change in Bacteroides-Prevotella and Lactobacillus
      • bovine milk (M)
        • Bacteroides-Prevotella and Lactobacillus increased
  • Probiotics:
    • [Combination of] “Lactobacillus salivarius LI01, Pediococcus pentosaceus LI05, … an increase in …Prevotella,  ” treatment with C. butyricum, B. licheniformis or L. rhamnosus GG did not have a significant effect.”[2017]
    • “Lactobacillus kefiri LKF01 DSM32079 (LKEF) …After one month of probiotic oral intake we observed a reduction of … Prevotella” [2017]
    • “Lactobacillus gasseri… increases prevotella [2016]
    • “Bifidobacterium animalis subsp. lactis (B. lactis) HN019 …lower proportions of …Prevotella intermedia-like species in rats with  experimental periodontitis (EP)” [2017] Note: no change without EP.
    • “Bifidobacterium bifidum strain Bb …  Prevotellaceae (P = 0.041) and Prevotella (P = 0.034) were significantly decreased” [2016]
    • ” Lactobacillus rhamnosus GG…causing an increase in the abundance of Prevotella, ” [2016]
    • “Probiotics [Lactobacillus rhamnosus GG (LGG), viable Escherichia coli Nissle 1917 (EcN), and heat-inactivated VSL#3 (1:1:1). ] shifted the gut microbial community toward certain beneficial bacteria, including Prevotella”
    • “Lactobacillus casei …Prevotella intermedia… showed moderately significant reduction in their numbers.” [2015]
    • “Streptococcus oralis KJ3, Streptococcus uberis KJ2 and Streptococcus rattus JH145 … the salivary Prevotella intermedia counts were significantly lower in the probiotic group.” [2015]
    • “Lactobacillus salivarius Ren (Ren) …increased the amount of Prevotella. ” [2015]
    • ” Lactobacillus reuteri DSM 17938 and PTA 5289 …reduced …. Prevotella maculosa detection. ” [2015]
    • ” a positive correlation between Lactobacillus casei Zhang (LcZ) and Prevotella” [2014]
    • Lactobacillus brevis CD2 inhibits Prevotella melaninogenica biofilm [2014].
    • ” enterotoxigenic Escherichia coli …  led to a reduction in the number of Bacteroides-Prevotella, ” [2014]
  • Antibiotics:
    • “a 7-day metronidazole regimen…Along with the decrease in pathogenic bacteria, such as … Prevotella…“
    • “All Prevotella strains tested were susceptible to imipenem and amoxicillin/clavulanate, whereas 78.6% of the pigmented Prevotellaspecies and 46.4% of the non-pigmented species were resistant to penicillin (MIC >0.5 μg/ml).” [2015]
    • “Cefpodoxime was found to be active at concentrations of less than or equal to 0.125 mg/l against Prevotella oralis, Prevotella buccalis” [1991]

Bottom Line

  • No Lactobacillus salivarius
  • No Lactobacillus gasseri
  • No Lactobacillus casei
  • No Lactobacillus rhamnosus GG.
  • No Rosemary