Decreasing Akkermansia genus

I did a post earlier this year on increasing this genus. As always, some are high and some are low. The working hypothesis is that the high genus are causing many symptoms. CFS have many symptoms — so different high genus are expected. This makes effective treatment more difficult; in theory with uBiome results we can individualize treatment for the person’s uBiome shifts.

For updated information see Microbiome Prescription

DataPunk.Net Data



PubMed Data

There are 330+ studies on PubMed

  • Disease:
    • “The intestinal microbiota of patients with constipated-predominant irritable bowel syndrome (C-IBS) …increase of Enterobacteriaceae, Desulfovibrio sp., and mainly Akkermansia muciniphila ” [2016]
    • “Lower numbers of this bacterium have been associated with diabetes, obesity, and IBD (31), and supplying a gluten-free diet to mice increased fecal levels of Akkermansia species (32). In contrast however another study found that levels of A. muciniphila were four times higher in patients with colorectal cancer than in healthy controls (33).”  [2015]
    • “atopic children showed a significant depletion in members of the …Akkermansia muciniphila ” [2012]
    • “decreased abundance of genus Akkermansia … in food allergy” [2017]
    • “we found a significant increase in some taxa such as Akkermansia in untreated multiple sclerosis twins. ” [2017]
    • “Differentially abundant gut microbes, such as Akkermansia, were observed in Parkinson’s disease ” [2017]
    • ” Akkermansia muciniphilaButyricicoccus pullicaecorum and Clostridium colinum were decreased in ulcerative colitis along with genus Roseburia.” [2017]
    • “Reduced in chronic urticaria ” [2017]
  • Diet:
  • Prebiotics:
    • “EpiCor fermentate .. a significant increase in Akkermansia muciniphila was observed.” [2017]
    • ” fructooligasaccharide administration showed certain effects on gut microbiota restoration (such as an increase of Akkermansia),” [2017]
    • Akkermansia muciniphila, belonging to mucin-degrading species, became a dominant species in Verrucomicrobia phylum after treatment with fructo-oligosaccharides and inulin.” [2017]
  • Probiotics:
    • Akkenmansia muciniphila probiotic in development [2017] [2017]
    • “The administration of Lactobacillus fermentum  FTDC 8312 also altered the gut microbiota population such as an increase in the members of genera Akkermansia” [2017]
    • “The present Lactobacillus plantarum study demonstrates that Akkermansia muciniphila was significantly enriched ” [2017]
      • ” Lactobacillus plantarum …significantly less… mucosa-damaging bacteria (Bilophila and Akkermansia muciniphila), ” [2017]
      • ” Lactobacillus plantarum — no change” [2013]
    • B. longum BB536 and L. rhamnosus HN001… the abundance of Akkermansia muciniphila was increased” [2017]
    • L. rhamnosus hsryfm 1301 …significantly increased the relative abundance of Bacteroides spp., Lactobacillus spp., Butyrivibrio spp., Holdemania spp., Treponema spp. and Akkermansiaspp.  [2014]
  • Antibiotics:
    • “Azithromycin induced a modest decline in microbiota richness and a shift in taxonomic composition driven by a reduction in the relative abundance of Proteobacteria and Verrucomicrobia (specifically Akkermansia muciniphila). ” [2017]

Bottom Line

  • Inconclusive: Lactobacillus plantarum, (B. longum BB536 and L. rhamnosus HN001 — which one does what?)