Decreasing Parabacteroides genus

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ANTIBIOTIC RESISTANCE

PubMed Data

There are 175+ studies on PubMed.

  • Disease:
    • “Despite this, there were significant correlations between the relative abundance of bacteria in the families Rickenellaceae and Ruminococcaceae, and the Parabacteroides and Dialister genera and temperament (i.e., Fear in girls and Activity Level and High-Intensity Pleasure in boys). ” [2015]
    • “Opportunistic pathogenic taxa, such as, Klebsiella spp., Streptococcus spp., and Parabacteroides merdae were frequently distributed in hypertensive gut microbiome,” [2017]
    • ” In contrast, Parabacteroidesdistasonis, which was reduced in multiple sclerosis  patients, ” [2017]
    • “We also found significant decreases in the numbers of Bacteroides, Parabacteroides… with food sensitization” [2016]
    • “Multiple sclerosis  decreased abundance of Parabacteroides” [2016]
    • Parabacteroides distasonis, …are depleted in metabolic syndrome  patients ” [2016]
    • ” relative abundance of Bacteroides, Parabacteroides, Faecalibacterium, and Prevotella was reduced in Sjögren syndrome ” [2016]
    • Parabacteroides species (increased in functional constipation) ” [2016]
    • ” while genera … Parabacteroides, .. were correlated with negative mood. ” [2016]
    • “we observed a decrease in the relative abundance of Alistipes, Bilophila, Dialister, Parabacteroides, and Veillonella in the Autism spectrum disorders  cohort, ” [2017]
    • Parabacteroides distasonis significantly decreased in inflamed tissue ,, in  inflammatory bowel disease” [2013]
    • Parabacteroides significantly decreased in IBS and UC” [2010]
    • Parabacteroides  increased .. in primary osteoporosis (OP) patients, osteopenia (ON) [2017]
    • “In Crohn’s disease, Parabacteroides distasonis was the most represented, ” [2017]
    • Parabacteroides distasonis, Klebsiella variicola, etc., were enriched in gestational diabetes mellitus  patients, ” [2017]
  • Diet:
    • “The abundance of Parabacteroides distasonis (P = .025) and Faecalibacterium prausnitzii (P = .020) increased after long-term consumption of the Med diet and the low-fat, high-complex carbohydrate diet diet, “[2016]
    • “resistant starch  diet caused significant shifts in microbial composition/diversity, with increases in Parabacteroides, ” [2016]
      • “resistant starch type 4 … enrichment of three Bacteroides species and one each of Parabacteroides” [2016] [2010]
      • “Proportions of the genus Parabacteroides significantly increased with Soluble corn fiber  dose” [2016]
    • “Rhizoma Coptidis (coptis root, which is also known as rhizoma coptidis and Huang Lian) alkaloids … Parabacteroides distasonis was suppressed.” [2016]
    • “free high-fat…  and.. restrictive high-fat diet …. decreased abundance of Parabacteroides bacteria” [2016]
    • “Canola oil… elevating Parabacteroides” [2016]
    • “Lingonberries increased the cecal relative abundance of bacterial genera Bacteroides, Parabacteroidesand Clostridium. ” [2016]
    • “Supplementation with rhubarb extract changed the microbial ecosystem (assessed by 16S rDNA pyrosequencing) in favor of Akkermansia muciniphila and Parabacteroides goldsteinii. ” [2017]
    • “Oral administration of resveratrol…  an increased relative abundance of Bacteroides and Parabacteroides” [2017]
    • “increase in Firmicutes and Parabacteroides, were seen in Alcholol fed group ” [2017]
    • “both the low- and high-capsaicin diets…decreased the Bacteroides and Parabacteroides abundances at the genus level. ” [2017]
  •  Probiotics:
    • “Lactobacillus casei Shirota  supplementation led to enrichment of Parabacteroides. ”  [2015]
    • Increase of L. Gasseri was seen with increase of Parabacteroides in some studies. [2011]
    • “one of two strains of human-derived Lactobacillus reuteri …after treatment with either probiotic strain was mediated in part by reductions in the relative proportions of Klebsiella and Parabacteroides in the feces. ” [2012]
    • “Lactobacillus rhamnosus GG … encourages formation of biofilms with Parabacteroides”[2016]
    • “The Parabacteroides genus was significantly increased in the healthy volunteers who received L. paracasei CNCM I-4034 after the second washout.” [2015]
  •  Antibiotics:
    • “In half or more studies, the resistance rates in Bacteroides/Parabacteroides spp. to amoxicillin-clavulanate or ampicillin-sulbactam and clindamycin rose…. No resistance changes were found to tigecycline, in Bacteroides/Parabacteroides spp.  ” [2015]
    • “Although metronidazole susceptibility was universal, nim genes were not present. ” [2014]
    • “Amoxicillin-Clavulanate  associated changes included reduced prevalence of the genus Roseburia and increases in Escherichia, Parabacteroides, ” [2017]

Bottom Line

Avoid

  • Lactobacillus rhamnosus GG
  • Lactobacillus paracasei
  • Lactobacillus casei Shirota (Yakult)
  • Lingonberries
  • Canole Oil
  • Resveratrol (Grapes, wine)
  • Rhubarb
  • Resistant Starch
  • Proton-pump inhibitors (PPI)
  • Amoxicillin-Clavulanate antibiotics

Take

  • Lactobacillus reuteri
  • Capsaicin (chili peppers)
  • high-fat diet
  • Metronidazole antibiotics