Addressing Muscle Weakness

With the model, there may be a lack of metabolites which will vary from person to person. The response will further vary according to DNA. A reader asked specifically about how to treat muscle weakness that often occurs after stress.

In this post, I will attempt to identify treatment options for muscle weakness

The PubMed Literature

Bottom Line

Avoid:

  • Germanium supplements
  • Red rice yeast
  • Statins

Take

  • Creatine – typically 20 g per day for 5 days) [1995] 3-5 g/day [Src]
  • L-Carnitine  – 250 mg/day  up to 2 g of l–carnitine every 12 h. [2004]
  • Thiamine (Vitamin B1) – “. All (IBD) patients were assigned to receive high doses of thiamine orally. Depending upon the body weight of each patient,
    dosage ranged from 600 mg/day (60 kg) to 1,500 mg/day (90 kg)” [2013]
  • Pyridoxine (Vitamin B6) – “120 mg vitamin B6; “[1999] [1983]
  • Vitamin D3
  • Potassium (One banana = 422 mg –  it is thought that 1600 to 2000 mg is adequate [Mayo Clinic – includes list of potassium rich food]
  • CoQ10 – if statins or red rice yeast contributed

This is an education post to facilitate discussing this with your medical professionals. It is not medical advice for the treatment of any condition. Always consult with your medical professional before doing any  changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.

Increasing Oxalobacter Formigenes

For updated information see Microbiome Prescription

uBiome’s Smart Gut associate low levels with various conditions.

“Oxalobacter formigenes (O. formigenes) is a nonpathogenic, Gram-negative, obligate anaerobic bacterium that commonly inhabits the human gut and degrades oxalate as its major energy and carbon source. Results from a case-controlled study suggested that lack of O. formigenes colonization is a risk factor for recurrent calcium oxalate stone formation. Hence, O. formigenes colonization may prove to be an efficacious method for limiting calcium oxalate stone risk.” [2016]

There appears to be a probiotic in progress:

DataPub.Net

Proteobacteria -> Betaproteobacteria -> Burkholderiales -> Oxalobacteraceae -> Oxalobacter -> Oxalobacter formigenes

INHIBITED BY

ENHANCED BY

PubMed etc

We have  180+ studies for Oxalobacter Formigenes

Disease

Diet

Prebiotic

Probiotic

Antibiotics

Bottom Line

Avoid

Take

Increasing Butyrivibrio Crossotus

For updated information see Microbiome Prescription

uBiome’s Smart Gut associate low levels with various conditions. Most of the studies deal with rumens (cows etc)

DataPub.Net

Firmicutes -> Clostridia -> Clostridiales -> Lachnospiraceae -> Butyrivibrio -> Butyrivibrio crossotus

For grand parent we have:

INHIBITED BY

ENHANCED BY

PubMed etc

We have 6+ studies for Butyrivibrio Crossotus, and  470+ studies for Butyrivibrio

Disease

Diet

  • “There was also a correlation between Lactobacillus ruminis and sialidase, as well as Butyrivibrio crossotus and xylanase/xylosidase.” [2017]
  • “Supplementation with marine[fish and algae] oils decreased the numbers of Butyrivibrio producers” [2017]

Prebiotic

Probiotic

Antibiotics

Bottom Line

Avoid

Take

Recommendations for microbiome-savvy physicians?

A reader asked for any recommendations of a microbiome savvy/understanding physician in Germany. Actually, the same applies to almost every country…. If you have suggestions, post them here as comments.

Reducing Citrobacter Freundii

For updated information see Microbiome Prescription

Doctor’s Data tests will reports on C. Freundii and this is a summary of what can be done to reduce it. Citrobacter (genus) material is included.

DataPub.Net

Gammaproteobacteria -> Enterobacteriales -> Enterobacteriaceae -> Citrobacter -> Citrobacter freundii 

Nothing

PubMed etc

“our lab showed that exposure to the prolonged-restraint stressor prior to a challenge with C. rodentium alters the intestinal microbiota community structure, including a reduction of beneficial genera such as Lactobacillus, which may contribute to stressor-enhanced C. rodentium-induced infectious colitis”  [2013]

Disease

  • “Urinary tract infections… abnormal inflammatory changes in the intestine, sometimes even resulting in necrotic changes….linked to neonatal meningitis” [edu]

Diet

Prebiotic

  • “Mice with pretreatment of L acidophilus, inulin, and both show reduced intestinal inflammation following Cr infection compared with controls” [2012]

Probiotic

  • “Preadministration and coadministration of a probiotic mixture containing Lactobacillus helveticus and Lactobacillus rhamnosus  ameliorated C. rodentium” [2012]
  • “While L. reuteri treatment did not reduce all aspects of stressor-enhanced infectious colitis, it did significantly reduce pathogen translocation from the colon to the spleen.”[2013]
  • “. The results showed that administration of a combination of probiotics including Lactobacillus rhamnosus ATCC 53103, Lactobacillus acidophilus ATCC 4356 and Lactobacillus plantarum A significantly increased the production of CD11c+ dendritic cells in the spleen (3.62% vs phosphate buffered saline (PBS)-treated control, P<0.01) and mesenteric lymph nodes (MLNs)… for  a model of Citrobacter rodentium-induced colitis” [2016]

Antibiotics

  • “usually treated with antibiotics like fluoroquinolones, carbapenems and cephalosporins. The treatment plan depends up on the vulnerability of the microbe to the antibiotics and the site of the infection. Conversely, there is a growing alarm over the levels of resistance of C. freundii to a number of antibiotics. Supportive treatment is given as well to hasten cure. ” [edu]
  • Further details.

Bottom Line

Avoid

  • Thymol

Take

  • Fiber
  • Fish Oil with Milk Fat
  • Inulin
  • Lactobacillus plantarum
  • Lactobacillus rhamnosus
  • Lactobacillus acidophilus
  • Lactobacillus Reuteri
  • Lactobacillus helveticus
  • Selenium
  • Vitamin E
  • Vitamin D
  • Vitamin B12
  • White button mushrooms